A Study to Evaluate Safety, Pharmacokinetics, and Activity of GDC-7035 as a Single Agent and in Combination in Patients With Advanced Solid Tumors
Start Date
11/14/2024
Completion Date
5/31/2028
Summary
This is a first-in-human Phase I/II, open-label, multicenter, dose-escalation and expansion study designed to evaluate the safety, pharmacokinetics, and preliminary activity of GDC-7035 as a single agent and in combination with other anti-cancer therapies in participants with advanced or metastatic solid tumors that harbor the KRAS G12D mutation.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Phase I Arm A
Phase I Arm B
Conditions
Locations
UC San Diego Moores Cancer Center
La Jolla, California 92093-1503
United States
Sarah Cannon Research Institute at HealthONE
Denver, Colorado 80218
United States
Yale Cancer Center
New Haven, Connecticut 06510
United States
Florida Cancer Specialist-Lake Mary
Lake Mary, Florida 32746
United States
University of Illinois
Chicago, Illinois 60612
United States
Dana Farber Cancer Institute
Boston, Massachusetts 02215
United States
START - Midwest - EDOS
Grand Rapids, Michigan 49546-7062
United States
Montefiore Einstein Cancer Center
The Bronx, New York 10461
United States
Mary Crowley Medical Research Center
Dallas, Pennsylvania 75230-2571
United States
Abramson Cancer Center;Univ of Pennsylvania
Philadelphia, Pennsylvania 19104-5127
United States
SCRI Oncology Partners
Nashville, Tennessee 37203
United States
O'Quinn Medical Tower at McNair Campus
Houston, Texas 77054
United States
St Vincent's Hospital Sydney
Darlinghurst, New South Wales 2010
Australia
Slade Health Inward goods
Mount Kuring-Gai, New South Wales 2080
Australia
Peter Maccallum Cancer Centre
Parkville, Victoria 3052
Australia
British Columbia Cancer Agency
Vancouver, British Columbia V5Z 4E6
Canada
Princess Margaret Cancer Centre
Toronto, Ontario M5G 1X6
Canada
Sir Mortimer B Davis Jewish General Hospital
Montreal, Quebec H3T 1E2
Canada
Gustave Roussy
Villejuif, Val-de-Marne 94805
France
Institut Bergonie
Bordeaux, 33076
France
Centre Georges Francois Leclerc
Dijon, 21000
France
Rambam Health Care Campus
Haifa, 3109601
Israel
Hadassah University Hospital - Ein Kerem
Jerusalem, 9112001
Israel
The Chaim Sheba Medical Center
Ramat Gan, 5262100
Israel
Tel Aviv Sourasky Medical Center PPDS
Tel Aviv, 6423906
Israel
National University Hospital
Singapore, 119074
Singapore
National Cancer Centre
Singapore, 168583
Singapore
Seoul National University Bundang Hospital
Seongnam, 13620
South Korea
Asan Medical Center.
Seoul, 005505
South Korea
Seoul National University Hospital
Seoul, 03080
South Korea
Severance Hospital, Yonsei University Health System
Seoul, 3722
South Korea
Instituto de Investigacion Oncologica Vall dHebron (VHIO) - EPON
Barcelona, 08035
Spain
Hospital Universitario 12 de Octubre
Madrid, 28041
Spain
START Madrid_Hospital Universitario HM Sanchinarro_CIOCC
Madrid, 28050
Spain
Hospital Universitario Virgen de la Victoria
Málaga, 29010
Spain
Hospital Universitario Virgen del Rocio - PPDS
Seville, 41013
Spain
Hospital Clinico Universitario de Valencia
Valencia, 46010
Spain
Western General Hospital;Edinburgh Cancer Center
Edinburgh, Midlothian EH4 2LF
United Kingdom
NIHR UCLH Clinical Research Facility
London, W1T 7HA
United Kingdom
The Christie
Manchester, M20 4BX
United Kingdom
Royal Marsden Hospital - Surrey
Sutton, SM2 5PT
United Kingdom