A Study to Investigate Safety and Effectiveness of BGB-16673 in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies
Start Date
11/27/2024
Completion Date
12/2/2029
Summary
The purpose of this study is to measure the safety, preliminary antitumor activity, pharmacokinetics, and pharmacodynamics with BGB-16673 in combination with other agents in participants with relapsed or refractory (R/R) B-cell malignancies. This study is structured as a master protocol with separate substudies. This study currently includes four substudies, and more substudies may be added as other combination agents are identified.
Detailed Description
This new study will check how safe and helpful a potential anticancer drug called BGB-16673 is in participants with R/R B-cell malignancies when it is given in combination with other medicines - sonrotoclax in substudy 1, zanubrutinib in substudy 2, mosunetuzumab in substudy 3, and glofitamab in substudy 4. Our company, previously known as BeiGene, is now officially BeOne Medicines. Because some of our older studies were sponsored under the name BeiGene, you may see both names used for this study on this website.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
BGB-16673
Sonrotoclax
Zanubrutinib
Mosunetuzumab
Glofitamab
Obinutuzumab
Conditions
Locations
Mayo Clinic Phoenix
Phoenix, Arizona 85054-4502
United States
University of Southern California Norris Comprehensive
Los Angeles, California 90033
United States
Mayo Clinic Jacksonville
Jacksonville, Florida 32224-1865
United States
Moffitt Cancer Center
Tampa, Florida 33612-9496
United States
The University of Kansas Cancer Center
Westwood, Kansas 66205-2003
United States
Mayo Clinic Rochester
Rochester, Minnesota 55905-0001
United States
Washington University School of Medicine
St Louis, Missouri 63110-1010
United States
Summit Medical Group
Florham Park, New Jersey 07932-1049
United States
Icahn School of Medicine At Mount Sinai
New York, New York 10029-6504
United States
Columbia University Medical Center
New York, New York 10032
United States
Weill Cornell Medical College Newyork Presbyterian Hospital
New York, New York 10065-4870
United States
Memorial Sloan Kettering Cancer Center Mskcc
New York, New York 10065-6800
United States
University of Rochester
Rochester, New York 14642-0001
United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111-2434
United States
The University of Texas Md Anderson Cancer Center
Houston, Texas 77030-4009
United States
Huntsman Cancer Institute
Salt Lake City, Utah 84112-5550
United States
University of Wisconsin
Madison, Wisconsin 53792-0001
United States
Medical College of Wisconsin
Milwaukee, Wisconsin 53226-3522
United States
St George Hospital
Kogarah, New South Wales NSW 2217
Australia
Mater Cancer Care Centre
South Brisbane, Queensland QLD 4101
Australia
Monash Health
Clayton, Victoria VIC 3168
Australia
Peter Maccallum Cancer Centre
Melbourne, Victoria VIC 3000
Australia
The Alfred Hospital
Melbourne, Victoria VIC 3004
Australia
Linear Clinical Research
Nedlands, Western Australia WA 6009
Australia
Hospital Sirio Libanes Brasilia
Brasília, 70200-730
Brazil
Ensino E Terapia de Inovacao Clinica Amo Etica
Salvador, 41950-640
Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose Do Rio Preto
São José do Rio Preto, 15090-000
Brazil
Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
São Paulo, 05652-900
Brazil
Fujian Medical University Union Hospital
Fuzhou, Fujian 350001
China
Sun Yat Sen University Cancer Center
Guangzhou, Guangdong 510060
China
The First Affiliated Hospital of Soochow University
Suzhou, Jiangsu 215006
China
The First Affiliated Hospital, Zhejiang University School of Medicinechengzhan
Hangzhou, Zhejiang 310002
China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang 325000
China
Universitatsklinikum Carl Gustav Carus An Der Technischen Universitat Dresden
Dresden, 01307
Germany
Universitatsklinikum Jena Klinik Fur Innere Medizin Ii
Jena, 07747
Germany
Universitatsklinikum Schleswig Holstein Campus Kiel
Kiel, 24105
Germany
Medizinische Universitaetsklinik
Tübingen, 72076
Germany
Universitaetsklinikum Ulm
Ulm, 89081
Germany
Azienda Ospedaliera Universitaria Policlinico Santorsola Malpighi
Bologna, 40138
Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milan, 20162
Italy
Istituto Nazionale Tumori Fondazione G Pascale
Naples, 80131
Italy
Istituto Clinico Humanitas
Rozzano, 20089
Italy
Centroricerche Cliniche Di Verona Srl
Verona, 37134
Italy
North Shore Hospital
Auckland, 0622
New Zealand
Auckland City Hospital
Auckland, 1023
New Zealand
Uniwersyteckie Centrum Kliniczne
Gdansk, 80-214
Poland
Uniwersytecki Szpital Kliniczny Nr 1 W Lublinie
Lublin, 20-081
Poland
Szpital Kliniczny Mswia Z Warmisko Mazurskim Centrum Onkologii
Olsztyn, 10-228
Poland
Szpital Wojewodzki W Opolu Sp Z Oo Oddzia Hematologii I Onkologii Hematologicznej
Opole, 45-061
Poland
Narodowy Instytut Onkologii Im Marii Sklodowskiej Curie W Warszawie
Warsaw, 02-781
Poland