A Study of Suvorexant (MK-4305) for the Treatment of Insomnia Disorder in Participants With Opioid Use Disorder (MK-4305-098)
Start Date
10/9/2025
Completion Date
6/24/2027
Summary
People with opioid use disorder (OUD) can have trouble falling or staying asleep. Researchers want to know if suvorexant will help people with OUD fall asleep and stay asleep. The goal of this study is to learn about the safety of suvorexant and how well people tolerate it. Researchers also want to learn if suvorexant helps people sleep longer compared to people who take placebo. A placebo looks like the study medicine but has no actual study medicine in it.
Eligibility Criteria
Age Range: 18 years to 70 years
Interventions
Suvorexant
Placebo
Conditions
Locations
Yale University School of Medicine ( Site 1003)
New Haven, Connecticut 06520
United States
CenExel iResearch, LLC ( Site 2010)
Savannah, Georgia 31405
United States
Johns Hopkins University ( Site 1001)
Baltimore, Maryland 21224
United States
Hassman Research Institute Marlton Site ( Site 2005)
Marlton, New Jersey 08053
United States
The Rivus Wellness & Research Institute ( Site 2014)
Oklahoma City, Oklahoma 73112
United States
Penn Medicine University of Pennsylvania Health System- Center for Studies of Addiction ( Site 1006)
Philadelphia, Pennsylvania 19104
United States
Butler Hospital ( Site 1002)
Providence, Rhode Island 02906
United States
Medical University of South Carolina ( Site 1005)
Charleston, South Carolina 29403
United States
Adams Clinical Dallas ( Site 2007)
DeSoto, Texas 75115
United States
Memorial Hermann Village ( Site 2001)
Houston, Texas 77043
United States
VCU Institute for Drug and Alcohol Studies ( Site 1004)
Richmond, Virginia 23219
United States