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NCT06693531Recruiting

A U.S. Registry of Eosinophilic Esophagitis Pediatric, Adolescent and Adult Patients Treated With DUPIXENT® As Standard of Care

Regeneron Pharmaceuticals

Start Date

11/22/2024

Completion Date

5/22/2030

Summary

This observational research study is to better understand patients with eosinophilic esophagitis (EoE) who have recently been prescribed DUPIXENT® (dupilumab). The purpose of this research study is to look at how DUPIXENT is used in normal care of patients with EoE. Possible benefits to others include a better understanding of EoE and helping to inform research and clinical trial design leading to treatment decisions in this patient population going forward. Patient questionnaires will measure the following: * How EoE makes one feel * EoE signs and/or symptoms, eg, how difficult it is to swallow * How EoE affects quality-of-life * How EoE impacts aspects of daily life * How EoE symptoms have changed throughout the study

Eligibility Criteria

Age Range: 1 years to No maximum

Key Inclusion Criteria: 1. Initiating treatment with DUPIXENT® for EoE according to the USPI 2. Participants aged ≥12 years and caregivers or legal guardians of participants aged \<12 years must be able to understand and complete registry-related questionnaires Key Exclusion Criteria: 1. Patients who have a contraindication to DUPIXENT® according to the USPI 2. Treatment with DUPIXENT® within the 6 months prior to the screening assessment 3. Participation in an ongoing interventional study on or within 6 months of the baseline assessment. Once enrolled in registry, participation is allowed in other ongoing studies (at the discretion of the registry investigator) NOTE: Other protocol defined inclusion/exclusion criteria apply

Interventions

DRUG

dupilumab

Interested in This Trial?

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Conditions

Eosinophilic Esophagitis (EoE)

Locations

Phoenix Childrens Hospital

Phoenix, Arizona 85016

United States

Arizona Digestive Health/GI Alliance

Sun City, Arizona 85351

United States

Arkansas Childrens Hospital

Little Rock, Arkansas 72202

United States

Scripps Clinic

La Jolla, California 92037

United States

University of California Los Angeles (UCLA)

Los Angeles, California 90024

United States

University of Southern California Keck School of Medicine

Los Angeles, California 90033

United States

University of California, San Francisco

Oakland, California 94609

United States

Stanford University

Palo Alto, California 94304

United States

University of California San Francisco (UCSF)

San Francisco, California 94115

United States

Childrens Hospital Colorado

Aurora, Colorado 80045

United States

University of Colorado Anschutz Medical Campus

Aurora, Colorado 80045

United States

Rocky Mountain Gastroenterology

Littleton, Colorado 80120

United States

UConn Health - The Carole and Ray Neag Comprehensive Cancer Center

Farmington, Connecticut 06030

United States

Yale School of Medicine

New Haven, Connecticut 06510

United States

Gastroenterology of Greater Orlando

Orange City, Florida 32763

United States

Orlando Health

Orlando, Florida 32806

United States

Emory Healthcare, Emory Clinic

Atlanta, Georgia 30322

United States

GI Care for Kids LLC

Atlanta, Georgia 30342

United States

Ann & Robert H. Lurie Children's Hospital of Chicago

Chicago, Illinois 60611

United States

Northwestern University, Feinberg School of Medicine

Chicago, Illinois 60611

United States

Comprehensive Gastrointestinal Health, LLC

Libertyville, Illinois 60048

United States

Endeavor Health, Skokie Campus

Skokie, Illinois 60077

United States

Kansas Gastroenterology LLC

Wichita, Kansas 67226

United States

Allergy & Asthma Specialists, P.S.C.

Owensboro, Kentucky 42301

United States

Boston Specialists, Chinatown Office

Boston, Massachusetts 02111

United States

Massachusetts General Hospital

Boston, Massachusetts 02114

United States

Boston Childrens Hospital

Boston, Massachusetts 02115

United States

Mayo Clinic

Rochester, Minnesota 55905

United States

GI Associates and Endoscopy Center

Flowood, Mississippi 39232

United States

Kansas City VA Medical Center

Kansas City, Missouri 64128

United States

Washington University in Saint Louis

St Louis, Missouri 63110

United States

Allergy Partners of N.J., P.C.

Ocean City, New Jersey 07712

United States

Steven And Alexandra Cohen Children's Medical Center Of New York

Lake Success, New York 11042

United States

Weil Cornell Medicine NYP

New York, New York 10021

United States

Icahn School of Medicine at Mount Sinai

New York, New York 10029

United States

Gastroenterology Group of Rochester LLP

Rochester, New York 14618

United States

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina 27599

United States

Duke University

Durham, North Carolina 27710

United States

Atrium Health / Wake Forest University School of Medicine

Winston-Salem, North Carolina 27157

United States

Great Lakes Gastroenterology Research, LLC

Mentor, Ohio 44060

United States

Susquehanna Research Group

Camp Hill, Pennsylvania 17011

United States

The Children's Hospital of Philadelphia

Philadelphia, Pennsylvania 19104

United States

University of Pennsylvania

Philadelphia, Pennsylvania 19104

United States

Medical University of South Carolina

Charleston, South Carolina 29425

United States

Palmetto Gastroenterology Clinical Research

Summerville, South Carolina 29486

United States

Vanderbilt University Medical Center

Nashville, Tennessee 37232

United States

Brooke Army Medical Center

Fort Sam Houston, Texas 78234

United States

Baylor College of Medicine

Houston, Texas 77030

United States

GI Alliance

Southlake, Texas 76092

United States

Tanner Clinic

Layton, Utah 84041

United States

University of Utah

Salt Lake City, Utah 84132

United States

University of Virginia

Charlottesville, Virginia 22908

United States

Seattle Children's Home Health Company

Seattle, Washington 98105

United States

Washington Gastroenterology, GIA

Tacoma, Washington 98405

United States

Medical College of Wisconsin

Milwaukee, Wisconsin 53226

United States