NCT06702670PHASE2, PHASE3Recruiting

Anticholinergics for Cervical Edema in Labor

The University of Texas Health Science Center, Houston

Start Date

3/25/2025

Completion Date

4/9/2027

Summary

The purpose of this study is to is to determine the clinical effectiveness of a single dose of intravenous (IV) medication for the prevention of labor arrest and cesarean delivery in primiparous women undergoing trial of labor.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Primiparous * Viable single intrauterine pregnancy -≥ 34 weeks of gestation * Ruptured membranes * Category I tracing at time of inclusion * Active phase of labor (\>=6 cm of cervix dilation) Exclusion Criteria: * Category II or III tracing * Allergy to the study medication (IV Diphenhydramine)

Interventions

DRUG

Treatment with Diphenhydramine

COMBINATION_PRODUCT

Usual Care

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Conditions

Labor Dystocia

Locations

The University of Texas Health Science Center at Houston

Houston, Texas 77030

United States