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NCT06712849NARecruitingAccepts Healthy Volunteers

Noninvasive Brain Stimulation in Adult Amblyopia

Midwestern University

Start Date

5/1/2024

Completion Date

12/31/2028

Summary

The goal of this randomized controlled trial is to investigate the effectiveness of non-invasive brain stimulation in treating adults with amblyopia. The main questions it aims to answer are: 1. What are the effects of non-invasive brain stimulation on neuronal plasticity in the visual cortex of adults with amblyopia, and does it produce lasting changes? 2. Do cumulative sessions of non-invasive brain stimulation influence neural plasticity and higher-order visual functions in adults with amblyopia? The investigators hypothesize that non-invasive brain stimulation will show a positive cumulative effect after five (5) consecutive days of stimulation on visual perception and function in adults with amblyopia. Participants will be randomized into one of two treatment groups: 1. High-frequency transcranial random noise stimulation (hf-tRNS). 2. Sham stimulation. Researchers will compare baseline measurements of crowded visual acuity, contrast sensitivity, stereoacuity, phosphene thresholds, global motion perception, form pattern recognition and pattern-reversal visual evoked potentials (VEPs) to post-treatment measurements for each group.

Eligibility Criteria

Age Range: 18 years to 55 years

Inclusion Criteria: * Adults between 18 and 55 years of age * Formal diagnosis of amblyopia in one or both eyes of any etiology Exclusion Criteria: * History of optic nerve disease, including glaucoma and optic neuritis * History of neurological conditions, including demyelinating disease or stroke * Presence of metal or electronic implants in or on the body, including pacemakers * Taking medications that can affect normal neurological function, including antipsychotics, antiepileptics, and opioids

Interventions

DEVICE

Sham Transcranial Random Noise Stimulation

DEVICE

High Frequency Transcranial Random Noise Stimulation

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Conditions

Amblyopia

Locations

Midwestern University Eye Institute

Downers Grove, Illinois 60515

United States