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NCT06719583RecruitingAccepts Healthy Volunteers

Black and African Americans Connections to Parkinson's Disease (BLAAC PD)

Michael J. Fox Foundation for Parkinson's Research

Start Date

11/16/2020

Completion Date

12/31/2027

Summary

BLAAC PD is a research study to understand what Parkinson's disease looks like for Black and African American communities. BLAAC PD is happening at research centers around the United States. The study is part of the Global Parkinson's Genetics Program (GP2). GP2 is a research project working to transform understanding of the genetics of Parkinson's disease and make that knowledge globally relevant.

Detailed Description

Research studies have found connections between genes and Parkinson's disease (PD). But those results have mostly come from studies with non-Black or African American volunteers. BLAAC PD aims to learn more about gene changes that may cause Parkinson's in Black and African American people. Study volunteers at sites across the United States will attend one visit and will give either a blood or saliva sample, complete a smell test, and may be asked to complete a physical exam. This new data could lead to future Parkinson's tests and treatments for Black and African American people and it may help better understand disease in other groups, too. This pioneering initiative will fill a gap of knowledge about PD in Black and African American people.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria for Control Participants: * Ability to provide informed consent * Age 50 years or older * Self-identify as Black or African American Exclusion Criteria for Control Participants: * Diagnosis of Parkinson's Disease and/or neurological condition * Familial history of PD and/or neurodegenerative or psychiatric conditions * Unknown family history of PD and/or neurodegenerative or psychiatric conditions * Any conditions that, in the investigator's opinion, preclude the individual's ability to carry out study activities * If submitting a saliva sample, nothing by mouth (food, drink, gum, tobacco, or smoking) for 30 minutes prior to sample collection Inclusion Criteria for Participants with a Diagnosis of PD: * Ability to provide informed consent * Age 18 years or older * Self-identify as Black or African American * Meet the Movement Disorder Society's clinical diagnostic criteria for Parkinson's disease Exclusion Criteria for Participants with a Diagnosis of PD: \- If submitting a saliva sample, nothing by mouth (food, drink, gum, tobacco, or smoking) for 30 minutes prior to sample collection

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Conditions

Parkinson Disease

Locations

University of Alabama at Birmingham

Birmingham, Alabama 35233

United States

University of Florida

Gainesville, Florida 32608

United States

Rush University

Chicago, Illinois 60612

United States

University of Chicago

Chicago, Illinois 60637

United States

Ochsner Clinic Foundation

New Orleans, Louisiana 70121

United States

Louisiana State University Health Sciences Center Shreveport

Shreveport, Louisiana 71103

United States

University of Maryland

Baltimore, Maryland 21201

United States

Kaiser Permanente Midatlantic States

Rockville, Maryland 20852

United States

Washington University in St. Louis

St Louis, Missouri 63119

United States

University Hospitals Cleveland Medical Center

Cleveland, Ohio 44106

United States

Medical University of South Carolina

Charleston, South Carolina 29425

United States

University of Texas Health Science Center, Houston

Houston, Texas 77030

United States