A Continuation Study of TAK-279 in Adults With Ulcerative Colitis (UC) and Crohn's Disease (CD)
Start Date
5/28/2025
Completion Date
12/30/2029
Summary
Crohn's Disease and Ulcerative Colitis are two types of inflammatory bowel disease (IBD), which is a serious, long-term condition in the gut (intestine) that can cause pain and swelling (inflammation) in the bowel. TAK-279 is a medicine which helps to block inflammation. This study is an extension of the parent studies, TAK-279-CD-2001 (NCT06233461), TAK-279-UC-2001 (NCT06254950) and TAK-279-CD-2003 (NCT07403968). This means that participants who responded to treatment with TAK-279 in either of the parent studies may be able to continue to benefit from the treatment in this study. The main aim of this study is to find out how safe TAK-279 is for long term use and to check if it reduces bowel inflammation and symptoms when used for a longer period of time in adults with moderately to severely active UC or CD. The participants will be treated with TAK-279 for up to 3 years (156 weeks). During the study, participants will visit their study clinic around 15 times.
Eligibility Criteria
Age Range: 18 years to 75 years
Interventions
Zasocitinib
Conditions
Locations
Woodholme Gastroenterology Associates
Glen Burnie, Maryland 21061
United States
Tyler Research Institute, LLC
Tyler, Texas 75701
United States
Chongqing General Hospital
Chongqing, Chongqing Municipality 400013
China
The First Affiliated Hospital of Sun Yat-sen University
Guangdong, Guangdong 510080
China
The Sixth Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong 510655
China
Renji Hospital Shanghai Jiaotong University School of Medicine
Shanghai, Shanghai Municipality 2000127
China
Hepato-Gastroenterologie HK s.r.o.
Hradec Králové, 500 12
Czechia
Pannonia Maganorvosi Centrum
Budapest, 1136
Hungary
St. Antonius Ziekenhuis
Tilburg, North Brabant 5022GC
Netherlands
Gastromed Kopon Zmudzinski i Wspolnicy Sp.j.Specjalistyczne Centrum Gastrologii i Endoskopii Specj
Torun, Kuyavian-Pomeranian Voivodeship 87-100
Poland
Centrum Medyczne MedykSp. z o.o. Sp. K.
Lublin, 35-326
Poland
Twoja Przychodnia - Szczecinskie Centrum Medyczne
Szczecin, 71-434
Poland
WIP Warsaw IBD Point Profesor Kierkus
Warsaw, 04-730
Poland
Endomed
Košice, 4013
Slovakia
Inje University Haeundae Paik Hospital
Haeundae, Busan Gwangyeogsi 48108
South Korea
Yonsei University Wonju Severance Christian Hospital
Wŏnju, Gangwon-do 220-701
South Korea