A Study Evaluating the Efficacy and Safety of Divarasib and Pembrolizumab Versus Pembrolizumab and Pemetrexed and Carboplatin or Cisplatin in Participants With Previously Untreated, KRAS G12C-Mutated, Advanced or Metastatic Non-Squamous Non-Small Cell Lung Cancer
Start Date
10/24/2025
Completion Date
10/31/2030
Summary
The purpose of this study is to evaluate the efficacy and safety of divarasib and pembrolizumab compared with pembrolizumab and pemetrexed and carboplatin or cisplatin, for the first-line treatment of adult participants with KRAS G12C-mutated, advanced or metastatic non squamous non-small cell lung cancer (NSCLC).
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Divarasib
Pembrolizumab
Pemetrexed
Carboplatin
Cisplatin
Conditions
Locations
Alaska Oncology and Hematology
Anchorage, Alaska 99508
United States
City of Hope - Phoenix
Goodyear, Arizona 85338
United States
Marin Cancer Care Inc
Greenbrae, California 94904
United States
Hoag Memorial Hospital
Newport Beach, California 92658
United States
Palo Alto Medical Foundation Research Center
Palo Alto, California 94301
United States
Sutter Institute for Medical Research
Roseville, California 95661
United States
California Pacific Medical Center
San Francisco, California 94115
United States
UC Health Oncology Research
Colorado Springs, Colorado 80909
United States
Poudre Valley Health Care, Inc. d/b/a Poudre Valley Health System
Fort Collins, Colorado 80528
United States
Hartford Hospital
Hartford, Connecticut 06102-5037
United States
Florida Cancer Specialists - SOUTH - SCRI - PPDS
Fort Myers, Florida 33901-8108
United States
University of Florida Health at Shands
Gainesville, Florida 32610
United States
BioResearch Partner
Hialeah, Florida 33013
United States
Memorial Healthcare System - Memorial Regional Hospital
Hollywood, Florida 33021
United States
Sylvester Comprehensive Cancer Center
Miami, Florida 33136
United States
Ascension Sacred Heart
Pensacola, Florida 32504
United States
Florida Cancer Specialists - NORTH - SCRI - PPDS
St. Petersburg, Florida 33701
United States
Florida Cancer Specialists - EAST - SCRI - PPDS
West Palm Beach, Florida 33401-3406
United States
Piedmont Cancer Institute, PC
Atlanta, Georgia 30318
United States
City of Hope® Atlanta
Newnan, Georgia 30265
United States
Summit Cancer Care PC
Savannah, Georgia 31405
United States
St. Luke's Cancer Institute
Boise, Idaho 83712
United States
Affiliated Oncologists, LLC
Chicago Ridge, Illinois 60415
United States
Hope and Healing Cancer Services
Hinsdale, Illinois 60521
United States
City of Hope® Cancer Center Chicago
Zion, Illinois 60099
United States
Mission Cancer + Blood - IMMC
Des Moines, Iowa 50309
United States
University of Iowa
Iowa City, Iowa 52242
United States
Saint Agnes Hospital - Baltimore - Hunt - PPDS
Baltimore, Maryland 21229-5201
United States
Massachusetts General Hospital
Boston, Massachusetts 02114
United States
Profound Research, LLC
Farmington Hills, Michigan 48334
United States
Missouri Baptist Medical Center
St Louis, Missouri 63131
United States
NHO Revive Research Institute
Lincoln, Nebraska 68506
United States
Cancer Care Specialists
Reno, Nevada 89511
United States
San Juan Oncology Associates
Farmington, New Mexico 87401
United States
Montefiore Einstein Cancer Center
The Bronx, New York 10461
United States
Clinical Research Alliance
Westbury, New York 11590
United States
Firsthealth of The Carolinas
Pinehurst, North Carolina 28374
United States
Ohio State University
Columbus, Ohio 43210
United States
Oregon Health and Science University
Portland, Oregon 97239
United States
St. Luke's University Health Network
Bethlehem, Pennsylvania 18015
United States
Allegheny Cancer Center
Pittsburgh, Pennsylvania 15212
United States
Reading Hospital - McGlinn Cancer Institute
West Reading, Pennsylvania 19611
United States
Baptist Cancer Center
Memphis, Tennessee 38120
United States
Renovatio Clinical - El Paso
El Paso, Texas 79915
United States
JPS Health Network
Fort Worth, Texas 76104
United States
The University of Texas MD Anderson Cancer Center
Houston, Texas 77030-4000
United States
Community Clinical Trials
Kingwood, Texas 77339
United States
Texas Tech Health Science Center
Lubbock, Texas 79415
United States
Renovatio Clinical
The Woodlands, Texas 77380
United States
University of Texas Health Center at Tyler
Tyler, Texas 75708
United States
Virginia Oncology Associates
Norfolk, Virginia 23502
United States
Hospital Aleman de Buenos Aires
Buenos Aires, C1118AAT
Argentina
Hospital Italiano
Buenos Aires, C1181ACH
Argentina
Hospital Britanico
Ciudad Autonoma Buenos Aires, C1280AEB
Argentina
Centro Oncologico Korben
Ciudad Autonoma Buenos Aires, C1426AGE
Argentina
Clinica Adventista Belgrano
Ciudad Autonoma Buenos Aires, C1430EGF
Argentina
Kinghorn Cancer Centre
Darlinghurst, New South Wales 2010
Australia
Liverpool Hospital
Liverpool, New South Wales 2170
Australia
Calvary Mater Newcastle
Waratah, New South Wales 2298
Australia
Sunshine Coast University Hospital
Birtinya, Queensland 4575
Australia
Royal Hobart Hospital
Hobart, Tasmania 7000
Australia
Monash Health
Clayton, Victoria 3168
Australia
Austin Health
Heidelberg, Victoria 3084
Australia
Peter Maccallum Cancer Centre
Melbourne, Victoria 3000
Australia
AZORG Campus Aalst-Moorselbaan
Aalst, 9300
Belgium
UZ Brussel
Brussels, 1090
Belgium
Cliniques Universitaires St-Luc
Brussels, 1200
Belgium
Jessa Zkh (Campus Virga Jesse)
Hasselt, 3500
Belgium
UZ Leuven Gasthuisberg
Leuven, 3000
Belgium
CHU de Liège (Sart Tilman)
Liège, 4000
Belgium
CHU HELORA - Hôpital de Mons - Site Kennedy
Mons, 7000
Belgium
AZ Delta (Campus Rumbeke)
Roeselare, 8800
Belgium
Crio - Centro Regional Integrado de Oncologia
Fortaleza, Ceará 60336-232
Brazil
Centro Integrado de Oncologia de Curitiba
Curitiba, Paraná 80810-050
Brazil
Liga Norte Riograndense Contra O Câncer
Natal, Rio Grande do Norte 59040150
Brazil
Irmandade Da Santa Casa de Misericordia de Porto Alegre
Porto Alegre, Rio Grande do Sul 90035-074
Brazil
Hospital Nossa Senhora da Conceicao
Porto Alegre, Rio Grande do Sul 90040-373
Brazil
Fundação Pio XII Hospital de Câncer de Barretos
Barretos, São Paulo 14784-400
Brazil
Instituto do Cancer do Estado de Sao Paulo - ICESP
São Paulo, São Paulo 01246-000
Brazil
BC Cancer ? Kelowna (Sindi Ahluwalia Hawkins Centre)
Kelowna, British Columbia V1Y 5L3
Canada
BC Cancer - Victoria
Victoria, British Columbia V8R 6V5
Canada
Royal Victoria Regional Health Centre
Barrie, Ontario L4M 6M2
Canada
William Osler Health Centre - Brampton Civic Hospital
Brampton, Ontario L6R 3J7
Canada
Ottawa Hospital Research Institute
Ottawa, Ontario K1H 8L6
Canada
Jewish General Hospital
Montreal, Quebec H3T 1E2
Canada
Centre Hospitalier Regional De Rimouski
Rimouski, Quebec G5L 5T1
Canada
Saskatoon Cancer Centre
Saskatoon, Saskatchewan S7N 4H4
Canada
CHU de Quebec - Hopital de l'Enfant-Jesus
Québec, G1J 1Z4
Canada
Hunan Cancer Hospital
Changsha, 410013
China
West China Hospital - Sichuan University
Chengdu, 611130
China
Sir Run Run Shaw Hospital Zhejiang University
Hangzhou, 310016
China
Harbin Medical University Cancer Hospital
Harbin, 150081
China
Fudan University Shanghai Cancer Center
Shanghai, 200032
China
Shanghai East Hospital
Shanghai, 200120
China
Shanghai Pulmonary Hospital
Shanghai, 200433
China
Tumor Hospital of the affiliated medical college of Shantou University
Shantou, 515000
China
Aarhus Universitetshospital
Aarhus N, 8200
Denmark
Herlev Hospital, Afdeling for Kræftbehandling, Center for Kræftforskning, Klinisk Forskningsenhed
Herlev, 2730
Denmark
Rigshospitalet
København Ø, 2100
Denmark
Sjællands Universitetshospital, Roskilde
Roskilde, 4000
Denmark
Onkologisk Ambulatorium - Sønderborg
Sønderborg, 6400
Denmark
CHU Angers
Angers, 49933
France
Hopital Avicenne
Bobigny, 93009
France
Hôpital Louis Pradel, Hospices Civils de Lyon
Bron, 69677
France
Centre Francois Baclesse
Caen, 14076
France
Centre Leon Berard
Lyon, 69008
France
CHU Montpellier
Montpellier, 34295
France
Centre Antoine Lacassagne
Nice, 06189
France
Groupe Hospitalier Paris Saint Joseph
Paris, 75014
France
Hopital Tenon
Paris, 75970
France
CHU Bordeaux
Pessac, 33604
France
Centre Hospitalier Universitaire de Reims
Reims, 51092
France
CH de Saint Quentin
Saint-Quentin, 02321
France
CHU Strasbourg - Nouvel Hopital Civil
Strasbourg, 67091
France
Centre Hospitalier Bretagne Atlantique Vannes
Vannes, 56017
France
Vivantes - Klinikum Im Friedrichshain;Innere Medizin ? Hämatologie, Onkologie und Palliativmedizin
Berlin, 10249
Germany
Charite - Universitätsmedizin Berlin
Berlin, 13353
Germany
Technische Universität Dresden - Medizinische Fakultät Carl Gustav Carus;Medizinische Klinik und Poliklinik I
Dresden, 01307
Germany
KEM/Evang. Kliniken Essen Mitte gGmbH
Essen, 45136
Germany
Universitätsklinikum Essen
Essen, 45147
Germany
Klinikum Esslingen
Esslingen am Neckar, 73730
Germany
Asklepios Fachkliniken GmbH
Gauting, 82131
Germany
LungenClinic Grosshansdorf GmbH
Großhansdorf, 22927
Germany
Krankenhaus Martha-Maria Halle-Doelau gGmbH
Halle, 06120
Germany
Universitätsklinikum Hamburg-Eppendorf
Hamburg, 20246
Germany
KRH Klinikum Siloah-Oststadt-Heidehaus
Hanover, 30459
Germany
Universität Des Saarlandes
Homburg, 66421
Germany
Lungenfachklinik Immenhausen
Immenhausen, 34376
Germany
ViDia Christliche Kliniken Karlsruhe;Medizinische Klinik 2, Studienzentrale Prof. MzB. / Raum G.018
Karlsruhe, 76137
Germany
SLK Kliniken Heilbronn GmbH, Standort Fachklinik Löwenstein
Löwenstein, 74245
Germany
Universitätsklinikum Schleswig-Holstein
Lübeck, 23538
Germany
Universität Mannheim
Mannheim, 68167
Germany
Klinikum Bogenhausen
München, 81925
Germany
Universitaetsklinikum Muenster
Münster, 48149
Germany
Pius Hospital Oldenburg
Oldenburg, 26121
Germany
Universitätsklinikum Regensburg
Regensburg, 93053
Germany
Klinikum Würzburg Mitte gGmbH
Würzburg, 97074
Germany
Sotiria General Hospital of Athens
Athens, 115 27
Greece
Alexandras Hospital
Athens, 115 28
Greece
Errikos Dynan Hospital
Athens, 11526
Greece
University Hospital of Larissa
Larissa, 411 10
Greece
Interbalkan Medical Center of Thessaloniki
Thessaloniki, 546 39
Greece
Theageneion Anticancer Hospital
Thessaloniki, 54639
Greece
Ag. Loukas Hospital
Thessaloniki, 55236
Greece
Queen Mary Hospital
Hong Kong,
Hong Kong
Tuen Mun Hospital
Hong Kong,
Hong Kong
Queen Elizabeth Hospital Department of Clinical Oncology
Kowloon, 000000
Hong Kong
Prince of Wales Hosp
Shatin,
Hong Kong
Orszagos Koranyi Pulmonologiai Intezet
Budapest, 1121
Hungary
Matrai Gyogyintezet
Mátraháza, 3233
Hungary
Pécsi Tudományegyetem
Pécs, 7623
Hungary
Református Pulmonológiai Centrum
Törökbálint, 2045
Hungary
St James Hospital
Dublin, D08 NHY1
Ireland
Beaumont Hospital
Dublin, D09V2N0
Ireland
Tallaght Hospital
Dublin, D24 NR0A
Ireland
Mater Misecordiae University Hospital
Dublin, Dublin 7
Ireland
Ospedale Giuseppe Moscati
Statte, Apulia 74010
Italy
AORN Ospedali dei Colli Ospedale Monaldi
Naples, Campania 80131
Italy
Istituto Nazionale Tumori Fondazione G. Pascale
Naples, Campania 80131
Italy
A.O. Universitaria Policlinico Di Modena
Modena, Emilia-Romagna 41100
Italy
Presidio san salvatore muraglia
Pesaro, Emilia-Romagna 61122
Italy
Irccs Centro Di Riferimento Oncologico (CRO)
Aviano, Friuli Venezia Giulia 33081
Italy
Azienda Ospedaliera San Camillo Forlanini
Rome, Lazio 00151
Italy
Policlinico Universitario "Agostino Gemelli"
Rome, Lazio 00168
Italy
IEO Istituto Europeo di Oncologia
Milan, Lombardy 20141
Italy
Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda)
Milan, Lombardy 20162
Italy
Azienda Ospedaliera San Gerardo di Monza
Monza MI, Lombardy 20900
Italy
Humanitas Centro Catanese Di Oncologia
Misterbianco (CT), Sicily 95045
Italy
USL 6 Toscana Nord Ovest ? P.O. Livorno
Livorno, Tuscany 57124
Italy
Ospedale P. Pederzoli Casa di cura Privata
Peschiera Del Garda (VR), Veneto 37019
Italy
Fujita Health University Hospital
Aichi, 470-1192
Japan
Kyushu University Hospital
Fukuoka, 812-8582
Japan
Kurume University Hospital
Fukuoka, 830-0011
Japan
Hakodate Goryoukaku Hospital
Hokkaido, 040-8611
Japan
Hyogo Medical University Hospital
Hyōgo, 663-8501
Japan
Kagoshima University Hospital
Kagoshima, 890-8520
Japan
Kanagawa Cancer Center
Kanagawa, 241-8515
Japan
Sendai Kousei Hospital
Miyagi, 981-0914
Japan
Niigata University Medical & Dental Hospital
Niigata, 951-8520
Japan
Okayama University Hospital
Okayama, 700-8558
Japan
Osaka Metropolitan University Hospital
Osaka, 545-8586
Japan
Kansai Medical University Hospital
Osaka, 573-1191
Japan
Kindai University Hospital
Osaka, 590-0197
Japan
Tohoku University Hospital
Sendai, 980-8574
Japan
Shizuoka Cancer Center
Shizuoka, 411-8777
Japan
National Cancer Center Hospital
Tokyo, 104-0045
Japan
Juntendo University Hospital
Tokyo, 113-8431
Japan
The Cancer Institute Hospital of JFCR
Tokyo, 135-8550
Japan
Tokyo Medical University Hospital
Tokyo, 160-0023
Japan
Wakayama Medical University Hospital
Wakayama, 641-8510
Japan
Hospital Civil de Guadalajara Fray Antonio Alcalde
Guadalajara, Jalisco 44280
Mexico
ARKE Estudios Clínicos S.A. de C.V.
Mexico City, 06700
Mexico
Meander Medisch Centrum
Amersfoort, Utrecht 3813 TZ
Netherlands
Ziekenhuis Rijnstate
Arnhem, 6815 AD
Netherlands
Amphia Ziekenhuis
Breda, 4818 CK
Netherlands
Ziekenhuis St. Jansdal
Harderwijk, 3844 DG
Netherlands
Medisch Centrum Haaglanden, locatie Antoniushove
Leidschendam, 2262 BA
Netherlands
Isala
Zwolle, 8025 AB
Netherlands
Harbour Cancer and Wellness
Auckland, 1023
New Zealand
Wellington Hospital
Newtown, 6021
New Zealand
Centrum Pulmonologii i Torakochirurgii
Bystra, 43-360
Poland
Uniwersyteckie Centrum Kliniczne
Gda?sk, 80-214
Poland
Krakowski Szpital Specjalistyczny im sw.Jana Pawla II
Krakow, 31-202
Poland
Uniwersytecki Szpital Kliniczny nr 4 w Lublinie
Lublin, 20-954
Poland
Warminsko-Mazurskie Centrum Chorób P?uc w Olsztynie
Olsztyn, 10-357
Poland
Wielkopolskie Centrum Pulmonologii i Torakochirurgii w Poznaniu
Poznan, 60-569
Poland
Radomskie Centrum Onkologii
Radom, 26-600
Poland
Instytut Gruzlicy I Chorob Pluc
Warsaw, 01-138
Poland
Mazowiecki Szpital Onkologiczny
Wieliszew, 05-135
Poland
Dolnoslaskie Centrum Chorob Pluc
Wroclaw, 53-439
Poland
Hospital de Braga
Braga, 4710-243
Portugal
Hospital Beatriz Angelo
Loures, 2674-514
Portugal
IPO do Porto
Porto, 4200-072
Portugal
CHVNG/E_Unidade 1
Vila Nova de Gaia, 4434-502
Portugal
National University Hospital
Singapore, 119228
Singapore
National Cancer Centre
Singapore, 168583
Singapore
Wits Donald Gordon Clinical Trial Centre
Parktown,
South Africa
Chris Hani Baragwanath Clinical Trial Site
Soweto, 2013
South Africa
Pusan National University Hospital
Busan, 49241
South Korea
Chungbuk National University Hospital
Cheongju-si, 28644
South Korea
Kyungpook National University Chilgok Hospital
Daegu, 41404
South Korea
The Catholic University of Korea, Seoul St. Mary's Hospital
Seoul, 06591
South Korea
Seoul National University Hospital
Seoul, 110-744
South Korea
Korea University Guro Hospital
Seoul, 8308
South Korea
Hospital Universitario Son Espases
Palma de Mallorca, Balearic Islands 07014
Spain
Hospital Universitario Marques de Valdecilla
Santander, Cantabria 39008
Spain
Complejo Hospitalario Universitario Insular?Materno Infantil
Las Palmas de Gran Canaria, LAS Palmas 35016
Spain
Clinica Universitaria de Navarra
Pamplona, Navarre 31008
Spain
Hospital Universitari Vall d Hebron
Barcelona, 08035
Spain
Hospital Clinic i Provincial de Barcelona
Barcelona, 08036
Spain
Hospital de la Santa Creu i Sant Pau
Barcelona, 08041
Spain
Clinica Universidad de Navarra Madrid
Madrid, 28027
Spain
Hospital Ramon y Cajal
Madrid, 28034
Spain
Hospital Universitario 12 de Octubre
Madrid, 28041
Spain
Hospital Universitario La Paz
Madrid, 28046
Spain
Hospital Clinico Universitario Virgen de la Victoria
Málaga, 29010
Spain
Hospital Universitario Virgen Macarena
Seville, 41009
Spain
Hospital Clínico Universitario de Valencia
Valencia, 46010
Spain
Kantonsspital Baden
Baden, 5404
Switzerland
Universitaetsspital Basel
Basel, 4031
Switzerland
Kantonsspital Graubünden Medizin Onkologie
Chur, 7000
Switzerland
Hôpital Universitaire de Genève (HUG)
Geneva, 1211
Switzerland
Kaohsiung Medical University Chung-Ho Memorial Hospital
Kaohsiung City, 80756
Taiwan
E-DA Hospital
Kaohsiung City, 824
Taiwan
Chung Shan Medical University Hospital
Taichung, 40201
Taiwan
National Taiwan University Hospital
Taipei, 00100
Taiwan
Taipei Medical University Hospital
Taipei, 110
Taiwan
Taipei Veterans General Hospital
Taipei, 112
Taiwan
National Taiwan University Cancer Center
Zhongzheng Dist., 106
Taiwan
Blackpool Teaching Hospitals NHS Foundation Trust , Victoria Hospital
Blackpool, FY3 8NR
United Kingdom
Bristol Haematology & Oncology Centre
Bristol, BS2 8ED
United Kingdom
East Kent Hospitals University NHS Foundation Trust
Canterbury, CT1 3NG
United Kingdom
Velindre NHS Trust - Velindre Cancer Centre
Cardiff, CF14 2TL
United Kingdom
Hull University Teaching Hospitals NHS Trust
Hull, HU3 2JZ
United Kingdom
Barts and the London NHS Trust
London, E1 2ES
United Kingdom
Royal Marsden Hospital - Fulham
London, SW3 6JJ
United Kingdom
Sarah Cannon Research Institute
London, W1G 6AD
United Kingdom
Maidstone and Tunbridge Wells NHS Trust
Maidstone, ME16 9QQ
United Kingdom
Oxford University Hospitals NHS Trust - Churchill Hospital
Oxford, OX3 7LE
United Kingdom
Royal Marsden NHS Foundation Trust
Sutton, SM2 5PT
United Kingdom