A Study to Evaluate the Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Maintenance Treatment Versus Standard of Care in Participants With Platinum-sensitive Recurrent Ovarian Cancer (MK-2870-022/TroFuse-022/ENGOT-ov84/GOG-3103)
Start Date
4/9/2025
Completion Date
11/9/2032
Summary
The main goals of this study are to learn about the safety of sacituzumab tirumotecan with bevacizumab and if people tolerate it; and if people who take sacituzumab tirumotecan with or without bevacizumab live longer without the cancer getting worse than those who receive standard of care treatment.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Sacituzumab tirumotecan
Bevacizumab
H1 receptor antagonist
H2 receptor antagonist
Acetaminophen (or equivalent)
Dexamethasone (or equivalent)
Steroid mouthwash (dexamethasone or equivalent)
Conditions
Locations
University of Alabama at Birmingham ( Site 0006)
Birmingham, Alabama 35249
United States
Alaska Women's Cancer Care ( Site 0096)
Anchorage, Alaska 99508
United States
UCSF Medical Center at Mission Bay ( Site 0013)
San Francisco, California 94158
United States
John Muir Health Cancer Center ( Site 0016)
Walnut Creek, California 94598
United States
Yale-New Haven Hospital-Smilow Cancer Hospital at Yale-New Haven ( Site 0001)
New Haven, Connecticut 06510
United States
Mount Sinai Braman Comprehensive Cancer Center ( Site 0078)
Miami Beach, Florida 33140
United States
Sarasota Memorial Hospital ( Site 0075)
Sarasota, Florida 34239
United States
Florida Cancer Specialists East ( Site 7000)
West Palm Beach, Florida 33401
United States
Winship Cancer Institute of Emory University ( Site 0086)
Atlanta, Georgia 30322
United States
Augusta University - Georgia Cancer Center ( Site 0066)
Augusta, Georgia 30912
United States
Parkview Research Center at Parkview Regional Medical Center ( Site 0003)
Fort Wayne, Indiana 46845
United States
Women's Cancer Care ( Site 0067)
Covington, Louisiana 70433
United States
Maine Medical Center Research Institute-MaineHealth/Maine Medical Partners - GynOnc ( Site 0008)
Scarborough, Maine 04074
United States
St. Dominic's Hospital ( Site 0064)
Jackson, Mississippi 39216
United States
Washington University School of Medicine ( Site 0052)
St Louis, Missouri 63110
United States
Nebraska Methodist Hospital ( Site 0053)
Omaha, Nebraska 68114
United States
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0081)
Hackensack, New Jersey 07601
United States
Rutgers Cancer Institute of New Jersey ( Site 0071)
New Brunswick, New Jersey 08901
United States
University of New Mexico Comprehensive Cancer Center ( Site 0055)
Albuquerque, New Mexico 87131
United States
NYU Langone Hospital - Long Island ( Site 0015)
Mineola, New York 11501
United States
Laura and Isaac Perlmutter Cancer Center ( Site 0076)
New York, New York 10016
United States
FirstHealth Cancer Center ( Site 0079)
Pinehurst, North Carolina 28374
United States
University of Cincinnati Medical Center ( Site 0090)
Cincinnati, Ohio 45219
United States
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C ( Site 0054)
Columbus, Ohio 43210
United States
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 0056)
Tulsa, Oklahoma 74146
United States
Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8010)
Eugene, Oregon 97401
United States
Allegheny Health Network West Penn Hospital ( Site 0099)
Pittsburgh, Pennsylvania 15224
United States
Women & Infants Hospital ( Site 0050)
Providence, Rhode Island 02905
United States
Henry-Joyce Cancer Clinic ( Site 0060)
Nashville, Tennessee 37232
United States
Texas Oncology - Central/South Texas ( Site 8009)
Austin, Texas 78758
United States
Texas Oncology - DFW ( Site 8001)
Fort Worth, Texas 76104
United States
Texas Oncology - San Antonio ( Site 8005)
San Antonio, Texas 78240
United States
Texas Oncology - Gulf Coast ( Site 8003)
Webster, Texas 77598
United States
Virginia Cancer Specialists (VCS) ( Site 8011)
Fairfax, Virginia 22031
United States
Instituto Alexander Fleming ( Site 2909)
Ciudad Autónoma de Buenos Aires, Buenos Aires C1426ANZ
Argentina
Instituto de Investigaciones Clinicas Mar del Plata ( Site 2901)
Mar del Plata, Buenos Aires B7600FZO
Argentina
Fundación Respirar ( Site 2912)
Buenos Aires, Buenos Aires F.D. C1426AAL
Argentina
Instituto de Oncologia de Rosario ( Site 2910)
Rosario, Santa Fe Province S2000KZE
Argentina
Hospital Aleman ( Site 2903)
CABA, C1118AAT
Argentina
Hospital Italiano de Cordoba ( Site 2908)
Córdoba, 5000
Argentina
Blacktown Hospital ( Site 0211)
Sydney, New South Wales 2148
Australia
Gallipoli Medical Research Ltd ( Site 0214)
Brisbane, Queensland 4120
Australia
Epworth Freemasons ( Site 0217)
East Melbourne, Victoria 3002
Australia
Frankston Hospital ( Site 0216)
Frankston, Victoria 3199
Australia
Antwerp University Hospital ( Site 0304)
Edegem, Antwerpen 2650
Belgium
Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman ( Site 0306)
Liège, Liege 4000
Belgium
AZ Sint-Lucas ( Site 0305)
Ghent, Oost-Vlaanderen 9000
Belgium
UZ Leuven ( Site 0301)
Leuven, Vlaams-Brabant 3000
Belgium
CHU UCL Namur/Site Sainte Elisabeth ( Site 0302)
Namur, 5000
Belgium
Liga Norte Riograndense Contra o Cancer ( Site 0423)
Natal, Rio Grande do Norte 59062-000
Brazil
Hospital São Lucas da PUCRS ( Site 0425)
Porto Alegre, Rio Grande do Sul 90610000
Brazil
ANIMI - Unidade de Tratamento Oncologico ( Site 0419)
Lages, Santa Catarina 88501-001
Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto ( Site 0413)
São José do Rio Preto, São Paulo 15090-000
Brazil
Instituto Nacional de Câncer - INCA ( Site 0422)
Rio de Janeiro, 20220-410
Brazil
Hospital Paulistano ( Site 0421)
São Paulo, 01321-001
Brazil
IBCC - Núcleo de Pesquisa e Ensino ( Site 0424)
São Paulo, 04014-002
Brazil
Arthur J.E. Child Comprehensive Cancer Centre ( Site 0512)
Calgary, Alberta T2N 5G2
Canada
Trillium Health Partners - Credit Valley Hospital ( Site 0508)
Mississauga, Ontario L5M 2N1
Canada
Princess Margaret Cancer Centre ( Site 0518)
Toronto, Ontario M5G 2M9
Canada
CIUSSS de l'Est-de-l'Île-de-Montréal ( Site 0505)
Montreal, Quebec H1T 2M4
Canada
McGill University Health Centre ( Site 0502)
Montreal, Quebec H4A 3J1
Canada
Clinica Puerto Montt ( Site 0615)
Port Montt, Los Lagos Region 5507642
Chile
Pontificia Universidad Catolica de Chile ( Site 0611)
Santiago, Region M. de Santiago 8330032
Chile
Bradfordhill-Clinical Area ( Site 0610)
Santiago, Region M. de Santiago 8420383
Chile
ONCOCENTRO APYS-ACEREY ( Site 0612)
Viña del Mar, Valparaiso 2520598
Chile
FUNDACION CTIC CENTRO DE TRATAMIENTO E INVESTIGACION SOBRE CANCER LUIS CARLOS SARMIENTO ANGULO ( Site 0806)
Bogotá, Bogota D.C. 110131
Colombia
Instituto Nacional De Cancerologia ( Site 0807)
Bogotá, Bogota D.C. 111511
Colombia
Oncologos Del Occidente ( Site 0805)
Pereira, Risaralda Department 660001
Colombia
Fakultni Nemocnice Brno Bohunice ( Site 3324)
Brno, Brno-mesto 602 00
Czechia
Fakultni nemocnice Ostrava ( Site 3323)
Ostrava-Poruba, Ostrava Mesto 708 52
Czechia
Vseobecna fakultni nemocnice v Praze ( Site 3325)
Prague, 128 08
Czechia
Fakultni nemocnice v Motole ( Site 3322)
Prague, 150 06
Czechia
Rigshospitalet ( Site 0904)
Copenhagen, Capital Region 2100
Denmark
Herlev Hospital ( Site 0903)
Herlev, Capital Region 2730
Denmark
Aalborg Universitetshospital ( Site 0901)
Aalborg, North Denmark 9000
Denmark
Vejle Sygehus ( Site 0902)
Vejle, Region Syddanmark 7100
Denmark
Oulun yliopistollinen sairaala ( Site 1003)
Oulu, North Ostrobothnia 90220
Finland
Kuopion Yliopistollinen Sairaala ( Site 1004)
Kuopio, Northern Savonia 70200
Finland
Tampereen yliopistollinen sairaala ( Site 1002)
Tampere, Pirkanmaa 33520
Finland
Centre Oscar Lambret ( Site 1104)
Lille, Ain 59020
France
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 1101)
Bordeaux, Aquitaine 33076
France
Centre Hopitalier Lyon Sud ( Site 1110)
Pierre-Bénite, Auvergne-Rhône-Alpes 69310
France
Centre Francois Baclesse ( Site 1108)
Caen, Calvados 14076
France
Hôpital Privé Des Côtes d'Armor ( Site 1106)
Plérin, Cotes-d Armor 22190
France
LBM ONCOPOLE CLAUDIUS REGAUD ( Site 1109)
Toulouse, Haute-Garonne 31059
France
Pôle Santé Léonard de Vinci ( Site 1112)
Chambray-lès-Tours, Indre-et-Loire 37170
France
Groupe Hospitalier Broca Cochin Hotel Dieu ( Site 1111)
Paris, Paris 75014
France
Institut De Cancerologie De L Ouest ( Site 1107)
Saint-Herblain, Pays de la Loire Region 44805
France
Sainte Catherine Institut du Cancer Avignon Provence ( Site 1105)
Avignon, Vaucluse 84918
France
Groupe Hospitalier Diaconesses Croix Saint Simon ( Site 1102)
Paris, 75020
France
Aretaieio Hospital ( Site 0701)
Athens, Attica 115 28
Greece
ATTIKON GENERAL UNIVERSITY HOSPITAL-Oncology ( Site 0702)
Chaïdári, Attica 12462
Greece
Bacs-Kiskun Megyei Korhaz ( Site 3920)
Kecskemét, Bács-Kiskun county 6000
Hungary
Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Onkoterapias Klinika ( Site 3924)
Szeged, Csongrád megye 6720
Hungary
Debreceni Egyetem Klinikai Kozpont ( Site 3922)
Debrecen, Hajdú-Bihar 4032
Hungary
Semmelweis Egyetem ( Site 3925)
Budapest, Pest County 1088
Hungary
Országos Onkológiai Intézet-Ngyógyászat ( Site 3923)
Budapest, Pest County 1122
Hungary
St James Hospital ( Site 1301)
Dublin, DO8 NHY1
Ireland
Hillel Yaffe Medical Center ( Site 1404)
Hadera, 3810101
Israel
Rambam Health Care Campus ( Site 1402)
Haifa, 3109601
Israel
Shaare Zedek Medical Center ( Site 1405)
Jerusalem, 9103102
Israel
Meir Medical Center. ( Site 1403)
Kfar Saba, 4428164
Israel
Sheba Medical Center ( Site 1401)
Ramat Gan, 5265601
Israel
CRO-IRCCS ( Site 1510)
Aviano, Friuli Venezia Giulia 33081
Italy
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1507)
Milan, Milano 20133
Italy
Azienda Ospedaliero Universitaria Pisana ( Site 1504)
Pisa, Tuscany 56126
Italy
Instituto Tumori Giovanni Paolo II ( Site 1505)
Bari, 70124
Italy
Istituto Ospedaliero,Fondazione Poliambulanza ( Site 1511)
Brescia, 25124
Italy
Istituto Europeo di Oncologia ( Site 1506)
Milan, 20141
Italy
Humanitas San Pio X Hospital ( Site 1503)
Milan, 20159
Italy
Istituto Nazionale Tumori IRCCS Fondazione Pascale ( Site 1501)
Naples, 80131
Italy
Istituto Oncologico Veneto IRCCS ( Site 1508)
Padova, 35128
Italy
Fondazione Policlinico Universitario Agostino Gemelli ( Site 1502)
Roma, 00168
Italy
Ospedale Mauriziano ( Site 1509)
Torino, 10128
Italy
Aichi Cancer Center ( Site 1626)
Nagoya, Aichi-ken 464-8681
Japan
National Cancer Center Hospital East ( Site 1641)
Kashiwa, Chiba 277-8577
Japan
National Hospital Organization Shikoku Cancer Center ( Site 1631)
Matsuyama, Ehime 791-0280
Japan
Ehime University Hospital ( Site 1637)
Tōon, Ehime 791-0295
Japan
Kurume University Hospital ( Site 1640)
Kurume, Fukuoka 830-0011
Japan
Gunma Prefectural Cancer Center ( Site 1630)
Ōta, Gunma 373-8550
Japan
Hokkaido University Hospital ( Site 1634)
Sapporo, Hokkaido 060-8648
Japan
Iwate Medical University Hospital ( Site 1635)
Shiwa-gun, Iwate 028-3695
Japan
Saitama Medical University International Medical Center ( Site 1632)
Hidaka, Saitama 350-1298
Japan
Shizuoka Cancer Center ( Site 1643)
Sunto-gun,, Shizuoka 411-8777
Japan
Cancer Institute Hospital of JFCR ( Site 1639)
Koto, Tokyo 135-8550
Japan
Keio University Hospital ( Site 1636)
Shinjyuku, Tokyo 160-8582
Japan
National Hospital Organization Kyushu Cancer Center ( Site 1628)
Fukuoka, 811-1395
Japan
Kagoshima City Hospital ( Site 1638)
Kagoshima, 890-8760
Japan
Niigata Cancer Center Hospital ( Site 1633)
Niigata, 951-8566
Japan
Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 1629)
Osaka, 541-8567
Japan
CIO - Centro de Inmuno-Oncología de Occidente ( Site 1719)
Guadalajara, Jalisco 44630
Mexico
Higiea Oncologia ( Site 1713)
Mexico City, Mexico City 11819
Mexico
Laboratorio de Patología Clínica del Hospital Universitario "Dr. José Eleuterio González" ( Site 1711)
Monterrey, Nuevo León 64460
Mexico
I CAN ONCOLOGY CENTER S.A. DE C.V. ( Site 1716)
Monterrey, Nuevo León 64710
Mexico
Servicios de Oncología Médica Integral - Monterrey ( Site 1712)
Monterrey, Nuevo León 66220
Mexico
Centro de Investigación Oncológica Galerías SC ( Site 1720)
Aguascalientes, 20124
Mexico
Cryptex Investigación Clínica S.A. de C.V. ( Site 1715)
Cuauhtémoc, 6100
Mexico
COI Centro Oncologico Internacional S.A.P.I. de C.V. ( Site 1717)
Mexico City, 04700
Mexico
Centro de Investigacion Clinica de Oaxaca ( Site 1714)
Oaxaca City, 68020
Mexico
Unidad de Investigacion Oncologia Clínica Piura ( Site 3606)
Castilla, Piura 20001
Peru
Hospital Guillermo Almenara Irigoyen ( Site 3608)
Lima, 15001
Peru
IPOR Instituto Peruano de Oncología & Radioterapia ( Site 3604)
Lima, 15036
Peru
INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 3601)
Lima, 15038
Peru
Clínica San Felipe ( Site 3603)
Lima, 15072
Peru
Hospital Cayetano Heredia ( Site 3607)
Lima, 15102
Peru
Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 2106)
Poznan, Greater Poland Voivodeship 61-848
Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Ginekologii Onkologicznej ( Site 2101)
Warsaw, Masovian Voivodeship 02-781
Poland
Bialostockie Centrum Onkologii ( Site 2104)
Bialystok, Podlaskie Voivodeship 15-027
Poland
Samodzielny Publiczny Szpital Kliniczny Nr 2 PUM w Szczecinie ( Site 2103)
Szczecin, West Pomeranian Voivodeship 70-111
Poland
Swietokrzyskie Centrum Onkologii. ( Site 2105)
Kielce, Świętokrzyskie Voivodeship 25-734
Poland
Hospital da Luz ( Site 3802)
Lisbon, 1500-650
Portugal
Inst. Portugues de Oncologia de Porto Francisco Gentil EPE ( Site 3801)
Porto, 4200-072
Portugal
Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 2215)
Cluj-Napoca, Cluj 400015
Romania
S.C. Centrul de Oncologie Sf. Nectarie SRL ( Site 2211)
Craiova, Dolj 200746
Romania
Cabinet Medical Oncomed ( Site 2217)
Timișoara, Timiș County 300239
Romania
Spitalul Clinic Filantropia ( Site 2213)
Bucharest, 011132
Romania
National Cancer Center ( Site 2305)
Goyang-si, Kyonggi-do 10408
South Korea
Severance Hospital ( Site 2302)
Seodaemun-Gu, Seoul 03722
South Korea
Asan Medical Center ( Site 2304)
Songpa-gu, Seoul 05505
South Korea
Seoul National University Hospital ( Site 2301)
Seoul, 03080
South Korea
Samsung Medical Center ( Site 2303)
Seoul, 06351
South Korea
Institut Català d'Oncologia (ICO) - Girona ( Site 2402)
Girona, Gerona 17007
Spain
Hospital General Gregorio Maranon de Madrid ( Site 2412)
Madrid, Madrid, Comunidad de 28007
Spain
Clinica Universidad de Navarra ( Site 2407)
Madrid, Madrid, Comunidad de 28027
Spain
Hosp Clinico Universitario de Valencia ( Site 2401)
Valencia, Valenciana, Comunitat 46010
Spain
Hospital Vall D Hebron ( Site 2403)
Barcelona, 08035
Spain
Hospital Clinic I Provincial de Barcelona ( Site 2409)
Barcelona, 08036
Spain
ICO L Hospitalet ( Site 2408)
Barcelona, 08907
Spain
Hospital Universitario Reina Sofia ( Site 2406)
Córdoba, 14004
Spain
Hospital Ramon y Cajal ( Site 2405)
Madrid, 28034
Spain
Hospital Clinico San Carlos... ( Site 2410)
Madrid, 28040
Spain
Hospital Universitario 12 de Octubre ( Site 2411)
Madrid, 28041
Spain
Hospital Universitario La Paz ( Site 2404)
Madrid, 28046
Spain
Taichung Veterans General Hospital ( Site 2603)
Taichung, 40705
Taiwan
National Cheng Kung University Hospital ( Site 2602)
Tainan, 704302
Taiwan
National Taiwan University Hospital ( Site 2601)
Taipei, 10002
Taiwan
Mackay Memorial Hospital ( Site 2604)
Taipei, 104
Taiwan
Chang Gung Memorial Hospital - Linkou Branch ( Site 2605)
Taoyuan, 333
Taiwan
Ramathibodi Hospital ( Site 3402)
Bangkok, Bangkok 10400
Thailand
Faculty of Medicine Siriraj Hospital ( Site 3401)
Bangkok, Bangkok 10700
Thailand
Cambridge University Hospital ( Site 2803)
Cambridge, Cambridgeshire CB2 2QQ
United Kingdom
Western General Hospital ( Site 2806)
Edinburgh, Edinburgh, City of EH4 2XU
United Kingdom
Royal Preston Hospital ( Site 2807)
Preston, Lancashire PR2 9HT
United Kingdom
ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 2801)
London, London, City of SW3 6JJ
United Kingdom
Royal Marsden Hospital (Sutton) ( Site 2802)
Sutton, London, City of SM2 5PT
United Kingdom
Leicester Royal Infirmary ( Site 2808)
Leicester, LE1 5WW
United Kingdom