NCT06830629PHASE2Recruiting

A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease

Maze Therapeutics

Start Date

2/5/2025

Completion Date

9/1/2026

Summary

The purpose of this study is to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with APOL1 Kidney Disease.

Detailed Description

An open-label Phase 2 study is designed to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with Proteinuric Chronic Kidney Disease and the APOL1 High Risk Genotype.

Eligibility Criteria

Age Range: 18 years to 68 years

Key Inclusion Criteria: * APOL1 high risk genotype of G1/G1, G2/G2, or G1/G2 * Chronic kidney disease with persistent albuminuria Key Exclusion Criteria: * Organ or bone marrow transplantation * History of active cancer within past 2 years, except for treated non-melanoma skin cancer, stage 0 cervical cancer, or stage 1 prostate cancer * Conditions that may alter drug absorption, e.g., history of bariatric surgery * Type I diabetes * Pregnant or currently nursing Other inclusion/exclusion criteria defined in protocol apply.

Interventions

DRUG

MZE829

Interested in This Trial?

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Conditions

Proteinuric Kidney Disease

Locations

Research Site

Decatur, Alabama 35601

United States

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Huntsville, Alabama 35805

United States

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Montgomery, Alabama 36106

United States

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Montgomery, Alabama 36117

United States

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Bloomfield, Connecticut 06112

United States

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Washington D.C., District of Columbia 20060

United States

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Atlantis, Florida 33462

United States

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Brandon, Florida 33511

United States

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Hollywood, Florida 33024

United States

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Melbourne, Florida 32901

United States

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Orlando, Florida 32822

United States

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Atlanta, Georgia 30309

United States

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College Park, Georgia 30349

United States

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Cordele, Georgia 31015

United States

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Macon, Georgia 31210

United States

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Riverdale, Georgia 30274

United States

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Riverdale, Georgia 30296

United States

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Savannah, Georgia 31406

United States

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Snellville, Georgia 30078

United States

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Chicago, Illinois 60616

United States

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Chicago, Illinois 60643

United States

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Evanston, Illinois 60201

United States

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Kansas City, Kansas 66112

United States

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Bowling Green, Kentucky 42101

United States

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Louisville, Kentucky 40205

United States

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Arnold, Maryland 21012

United States

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Lutherville, Maryland 21093

United States

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Oxon Hill, Maryland 20745

United States

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Dearborn, Michigan 48126

United States

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Flint, Michigan 48503

United States

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Pontiac, Michigan 48341

United States

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Saint Joseph, Michigan 49085

United States

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Minneapolis, Minnesota 55404

United States

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Tupelo, Mississippi 38801

United States

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City of Saint Peters, Missouri 63376

United States

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St Louis, Missouri 63103

United States

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Las Vegas, Nevada 89107

United States

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Jersey City, New Jersey 07305

United States

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Buffalo, New York 14203

United States

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Laurelton, New York 11413

United States

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Maspeth, New York 11378

United States

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Newburgh, New York 12550

United States

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Durham, North Carolina 27708

United States

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Fayetteville, North Carolina 28304

United States

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Greensboro, North Carolina 27405

United States

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Shelby, North Carolina 28150

United States

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Cleveland, Ohio 44106

United States

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Cleveland, Ohio 44195

United States

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Columbus, Ohio 43215

United States

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Ardmore, Oklahoma 73401

United States

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Philadelphia, Pennsylvania 19104

United States

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Philadelphia, Pennsylvania 19107

United States

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Upland, Pennsylvania 19013

United States

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Columbia, South Carolina 29203

United States

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Spartanburg, South Carolina 29302

United States

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Spartanburg, South Carolina 29306

United States

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Chattanooga, Tennessee 37404

United States

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Dallas, Texas 75230

United States

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Dallas, Texas 75246

United States

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Greenville, Texas 75402

United States

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Houston, Texas 77030

United States

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Houston, Texas 77054

United States

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Houston, Texas 77099

United States

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McKinney, Texas 75069

United States

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San Antonio, Texas 78251

United States

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Shenandoah, Texas 77384

United States

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Sherman, Texas 75092

United States

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Norfolk, Virginia 23504

United States

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Créteil, 94010

France

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Lille, 59037

France

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Lyon, 69347

France

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Paris, 75015

France

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Paris, 75018

France

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Paris, 75020

France

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Saint-Ouen, 93400

France

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Leicester, LE5 4PW

United Kingdom

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London, NW3 2QG

United Kingdom

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London, SE19RT

United Kingdom

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London, SE59RS

United Kingdom