An Open-Label Pilot Study of VTX2735 in Recurrent Pericarditis
Start Date
1/28/2025
Completion Date
10/1/2027
Summary
This is a study to understand if taking VTX2735 is safe and effective in participants diagnosed with Recurrent Pericarditis (RP). Cohort A will include approximately 10 participants and will consist of the following: * A 30-day Screening Period (to see if a participant qualifies for the study) * A 6-week Open Label Treatment Period - participant receives VTX2735 Dose A * A 7-week Extension Treatment Period (if a participant meets criteria for extension treatment) - participant receives VTX2735 Dose A * An 11-week Once Daily Treatment Period (if a participant meets criteria for this treatment period) - participant receives VTX2735 Dose B * A 14-day Follow-Up Period Cohort B will include approximately 20 participants and will consist of the following: * A 30-day Screening Period (to see if a participant qualifies for the study) * A 6-week Open Label Treatment Period - participant receives VTX2735 Dose B or C * An 18-week Extension Treatment Period (if a participant meets criteria for extension treatment) - participant receives VTX2735 Dose B or C * A 14-day Follow-Up Period Cohort C will include approximately 20 participants and will consist of the following: * A 30-day Screening Period (to see if a participant qualifies for the study) * A 6-week Open Label Treatment Period - participant receives VTX2735 Dose D or E, and B * An 18-week Extension Treatment Period (if a participant meets criteria for extension treatment) - participant receives VTX2735 Dose B * A 14-day Follow-Up Period
Eligibility Criteria
Age Range: 18 years to 75 years
Interventions
VTX2735
VTX2735
VTX2735
VTX2735
VTX2735
Conditions
Locations
Local Site #840012
Tucson, Arizona 85718
United States
Local Site #840014
Orange, California 92868
United States
Local Site #840016
Saint Augustine, Florida 32086
United States
Local Site #840008
Chicago, Illinois 60611
United States
Local Site #840002
Park Ridge, Illinois 60068
United States
Local Site #840011
Owensboro, Kentucky 42303
United States
Local Site #840010
Boston, Massachusetts 02114
United States
Local Site #840005
Rochester, Minnesota 55905
United States
Local Site #840020
New York, New York 10032
United States
Local Site #840017
Cleveland, Ohio 44195
United States
Local Site #840019
Houston, Texas 77030
United States
Local Site #840001
Houston, Texas 77034
United States
Local Site #840013
Salt Lake City, Utah 84132
United States
Local Site #840022
Burlington, Vermont 05401
United States
Local Site #840018
Charlottesville, Virginia 22908
United States
Local Site #840004
Richmond, Virginia 23219
United States
Local Site #840021
Seattle, Washington 98105
United States
Local Site #840101
Ottawa, Ontario K1Y 4W7
Canada