An Open-Label Pilot Study of VTX2735 in Recurrent Pericarditis
Start Date
1/28/2025
Completion Date
10/1/2027
Summary
This is a study to understand if taking VTX2735 is safe and effective in participants diagnosed with Recurrent Pericarditis (RP). Cohort A will include approximately 10 participants and will consist of the following: * A 30-day Screening Period (to see if a participant qualifies for the study) * A 6-week Open Label Treatment Period - participant receives VTX2735 Dose A * A 7-week Extension Treatment Period (if a participant meets criteria for extension treatment) - participant receives VTX2735 Dose A * An 11-week Once Daily Treatment Period (if a participant meets criteria for this treatment period) - participant receives VTX2735 Dose B * A 14-day Follow-Up Period Cohort B will include approximately 20 participants and will consist of the following: * A 30-day Screening Period (to see if a participant qualifies for the study) * A 6-week Open Label Treatment Period - participant receives VTX2735 Dose B or C * An 18-week Extension Treatment Period (if a participant meets criteria for extension treatment) - participant receives VTX2735 Dose B or C * A 14-day Follow-Up Period Cohort C will include approximately 20 participants and will consist of the following: * A 30-day Screening Period (to see if a participant qualifies for the study) * A 6-week Open Label Treatment Period - participant receives VTX2735 Dose D or E, and B * An 18-week Extension Treatment Period (if a participant meets criteria for extension treatment) - participant receives VTX2735 Dose B * A 14-day Follow-Up Period
Eligibility Criteria
Age Range: 18 years to 75 years
Interventions
VTX2735
VTX2735
VTX2735
VTX2735
VTX2735
Conditions
Locations
UC San Diego Health
La Jolla, California 92037
United States
University of California Irvine Medical Center
Orange, California 92868
United States
Flourish Research - St. Augustine - PPDS
Saint Augustine, Florida 32086
United States
Bluhm Cardiovascular Institute of Northwestern
Chicago, Illinois 60611
United States
MGH Heart Failure and Cardiac Transplant Center Corrigan Minehan Heart Center
Boston, Massachusetts 02114
United States
Mayo Clinic
Rochester, Minnesota 55905-0002
United States
Columbia University Irving Medical Center
New York, New York 10032
United States
The Cleveland Clinic Foundation
Cleveland, Ohio 44195
United States
Houston Methodist Hospital
Houston, Texas 77030
United States
Orion Medical
Houston, Texas 77034
United States
University of Utah
Salt Lake City, Utah 84132
United States
University of Vermont Medical Center
Burlington, Vermont 05401
United States
University of Virginia Health System Advanced Heart Failure and Transplant Center
Richmond, Virginia 23298
United States
VCU North Hospital
Richmond, Virginia 23298
United States
Seattle Children's Hospital
Seattle, Washington 98105
United States
University Hospital Ghent
Ghent, 9000
Belgium
University Hospitals Leuven, Campus Gasthuisberg
Leuven, 3000
Belgium
McGill University Health Centre
Montreal, H4A 3J1
Canada
University of Ottawa Heart Institute
Ottawa, K1Y 4S7
Canada
General Hospital of Athens "Ippokratio"
Athens, 11527
Greece