Studying the Presence of CFRD Complications With Thoughtful Recruitment (SPeCTRuM)

Inclusion Criteria: * Written informed consent (and assent when applicable) obtained from participant or participant's legally authorized representative * For Adults: Must be able to consent on one own's behalf (i.e., cannot lack cognitive capacity to consent due to the required patient-reported outcomes) * Be willing and able to adhere to the study protocol requirements * Age ≥ 12 years at time of enrollment * CF diagnosis based on two CF causing mutations and/or positive sweat test according to CFF diagnostic criteria * CFRD diagnosis ≥ 5 years at time of enrollment Exclusion Criteria: * History of any illness or condition that, in the opinion of the investigator might confound the results of the study or pose an additional risk to the subject * History of transplant * Pregnancy reported by participant at time of consent or at any point during active study participation Pulse Wave Velocity Exclusion Criteria: * Erratic, accelerated or mechanically controlled irregular heart rhythms including arrhythmias * Carotid or aortic valve stenosis * Peripheral artery disease or leg artery disease * Generalized constriction or localized spasm of muscular conduit arteries such as seen immediately after hypothermic cardiopulmonary bypass surgery or accompanying Raynaud's phenomena or intense cold. * Possible exclusions based on investigator medical provider assessment (additional precautions may be followed to allow inclusion): * Pressure reading should not be conducted on a limb where there is intravenous access, arterio-venous shunt, or where circulation is compromised. * Pressure reading should not be conducted on the side of the body that a mastectomy was done.