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NCT06860698RecruitingAccepts Healthy Volunteers

The Impact of Chronic E-Cigarette Usage on Microvascular Health

Virginia Commonwealth University

Start Date

7/14/2023

Completion Date

7/28/2026

Summary

The study is focused on investigating the mechanisms involved in microvascular health in subjects that use e-cigarettes frequently. To explore microvascular health, different techniques and compounds. For one of the tests, iontophoresis, the drug's use will be stored and handled as described by the approved IND and non-IDS plan.

Detailed Description

Electronic cigarettes or e-cigarettes have become increasingly popular, due to their promotion as a healthy alternative to traditional tobacco cigarettes. However, there are large discrepancies of knowledge in understanding how these e-cigarettes affect the subjects health and the way their body uses oxygen. The overall goal of this study is to evaluate e-cigarettes usage on subjects health.

Eligibility Criteria

Age Range: 18 years to 29 years

e-Cig users arm Inclusion Criteria: * Between 18 and 29 years of age * Used e-cigarettes with nicotine (≥3 times/week for ≥6 months) Exclusion Criteria: * 17 years old and younger or 30 years old or older. * Former combustible tobacco user/ former smoker * Use of cigarettes for 15 days or more in the past 60 days * Use of other tobacco products (cigars, hookah, smokeless), marijuana and/or illicit or prescription drugs weekly or more frequently in the past 60 days * Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders * Disorder or use of medication that affects cardiopulmonary health * Evidence of pregnancy or current nursing Non e-Cig using arm Inclusion \- Between 18 and 29 years of age Exclusion * 17 years old and younger or 30 years old and older * Use of cigarettes or other tobacco products more than 50 times in their lifetime. * Evidence of cardiovascular, pulmonary, renal, hepatic, metabolic, cerebral diseases or sleep disorders * Disorder or use of medication that affects cardiopulmonary health * Evidence of pregnancy or current nursing

Interventions

OTHER

E-cig use

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Conditions

E-Cig Use

Locations

Virginia Commonwealth University

Richmond, Virginia 23298

United States