A Study of PARP1 Selective Inhibitor, EIK1004 (IMP1707) in Participants With Advanced Solid Tumors.
Start Date
4/30/2025
Completion Date
12/1/2028
Summary
This study will evaluate the safety, tolerability, and preliminary efficacy of EIK1004 (IMP1707) in participants with recurrent advanced/metastatic breast cancer, ovarian cancer, metastatic castrate resistant prostate cancer (mCRPC) and pancreatic cancer with deleterious/suspected deleterious mutations of select homologous recombination repair (HRR) genes. Condition or disease Intervention/treatment Phase Advanced Solid Tumors Drug: EIK1004 (IMP1707) Phase 1/Phase 2
Detailed Description
This study will evaluate the safety, tolerability and preliminary efficacy of EIK1004 (IMP1707) as monotherapy in patients with recurrent, advanced/metastatic solid tumors. The study consists of 2 parts: Dose escalation and dose optimization. In dose escalation (Part1), the study will identify the maximum tolerated dose (MTD) or maximum achievable dose (MAD) in solid tumor. In dose optimization (Part 2), the study will further evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and anti-tumor activity of select doses of EIK1004 (IMP1707)
Eligibility Criteria
Age Range: 18 years to 89 years
Interventions
EIK1004-001 (IMP1707-001)
Conditions
Locations
Sarah Cannon Research Institute at HealthOne
Denver, Colorado 80218
United States
Florida Cancer Center
Lake Mary, Florida 32746
United States
Beth Israel Deaconess Medical Center
Boston, Massachusetts 02215
United States
MD Anderson
Houston, Texas 77030
United States
NEXT Oncology
San Antonio, Texas 78229
United States
NEXT Virginia
Fairfax, Virginia 22031
United States
PASO Medical
Frankston, Victoria 3199
Australia
Chongqing University Cancer Hospital
Chongqing, Chongqing Municipality 400030
China
Cancer Hospital of Shandong First Medical University(Shandong Cancer Institute, Shandong Cancer Hospital)
Jinan, Shandong 250117
China
Fudan University Shanghai Cancer Center
Shanghai,
China