A Study to Investigate Progression-Free Survival With Sonrotoclax Plus Obinutuzumab Or Sonrotoclax Plus Rituximab Compared With Venetoclax Plus Rituximab Treatment In Patients With Relapsed and/or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CELESTIAL-RRCLL)
Start Date
6/11/2025
Completion Date
12/1/2031
Summary
The goal of this study is to compare how well sonrotoclax plus obinutuzumab works versus venetoclax plus rituximab in treating adults with relapsed and/or refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The study will also compare how well sonrotoclax plus rituximab works versus venetoclax plus rituxumab in treating adults with R/R CLL/SLL. The safety of these treatments will also be assessed.
Detailed Description
Our company, previously known as BeiGene, is now officially BeOne Medicines. Because some of our older studies were sponsored under the name BeiGene, you may see both names used for this study on this website.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Sonrotoclax
Obinutuzumab
Rituximab
Venetoclax
Conditions
Locations
Uci Health Laguna Hills
Laguna Hills, California 92653
United States
Chao Family Comprehensive Cancer Center
Orange, California 92868-3201
United States
Stanford Cancer Institute
Palo Alto, California 94304-2205
United States
Scripps Prebys Cancer Center
San Diego, California 92103-2106
United States
Rocky Mountain Cancer Centers (Williams) Usor
Aurora, Colorado 80012-5405
United States
Yale University Yale Cancer Center
New Haven, Connecticut 06520-8028
United States
Eastern Connecticut Hematology and Oncology
Norwich, Connecticut 06360-2700
United States
Cleveland Clinic Florida
Weston, Florida 33331-3609
United States
Northwestern University
Chicago, Illinois 60611
United States
Illinois Cancer Specialists (Niles) Usor
Niles, Illinois 60714-5905
United States
University of Iowa Hospitals and Clinics
Iowa City, Iowa 52242-1009
United States
Mission Cancer and Blood
Waukee, Iowa 50263
United States
University of Louisville, Brown Cancer Center
Louisville, Kentucky 40202
United States
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana 70809-3738
United States
The University of Maryland Greenebaum Comprehensive Cancer Center
Baltimore, Maryland 21201
United States
Beth Israel Deaconess Medical Center (Bidmc)
Boston, Massachusetts 02215-5400
United States
Dana Farber Cancer Institute
Boston, Massachusetts 02215-5418
United States
The Cancer and Hematology Centers
Grand Rapids, Michigan 49503-2563
United States
Mayo Clinic Rochester
Rochester, Minnesota 55905-0001
United States
Sidney Kimmel Comprehensive Cancer Center Washington Twp
Sewell, New Jersey 08080
United States
Christus St Vincent Regional Cancer Center
Santa Fe, New Mexico 87505
United States
Memorial Sloan Kettering Cancer Center Mskcc
New York, New York 10065-6800
United States
Optum Medical Care, Pc
Westbury, New York 11590-5119
United States
University of North Carolina At Chapel Hill
Chapel Hill, North Carolina 27514-4220
United States
Levine Cancer Center
Charlotte, North Carolina 28204-2990
United States
Atrium Health Wake Forest Baptist
Winston-Salem, North Carolina 27157
United States
Oncology Hematology Care Clinical Trials, Llc
Cincinnati, Ohio 45245-1995
United States
Oncology Associates of Oregon Willamette Valley Cancer Center
Eugene, Oregon 97401
United States
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania 17033
United States
Thomas Jefferson University
Philadelphia, Pennsylvania 19107-4216
United States
Upmc Hillman Cancer Center(Univ of Pittsburgh)
Pittsburgh, Pennsylvania 15232-1309
United States
Tennessee Oncology Greco Hainsworth Centers For Research Chattanooga
Chattanooga, Tennessee 37404
United States
Tennessee Oncology
Nashville, Tennessee 37205
United States
Texas Oncology Baylorcharles A Sammons Cancer Center
Dallas, Texas 75246-2003
United States
Texas Oncology San Antonio Medical Center Usor
San Antonio, Texas 78240-5251
United States
Texas Oncology Tyler
Tyler, Texas 75702-7522
United States
Swedish Medical Center Swedish Cancer Institute First Hill Campus
Seattle, Washington 98104
United States
Northwest Cancer Specialist, Pc(Us Oncology Research)
Vancouver, Washington 98684-6930
United States
Hospital Aleman
CABA, 1425
Argentina
FUNDALEU
Caba, CP1114
Argentina
Instituto Alexander Fleming (Iaf)
Ciudad Autonoma Buenos Aires, 1426
Argentina
Blacktown Cancer and Haematology Centre
Blacktown, New South Wales NSW 2148
Australia
St George Hospital
Kogarah, New South Wales NSW 2217
Australia
Northern Nsw Health District
Lismore, New South Wales NSW 2480
Australia
Macquarie University
North Ryde, New South Wales NSW 2109
Australia
Genesiscare North Shore
St Leonards, New South Wales NSW 2065
Australia
Sunshine Coast Hospital and Health Service
Birtinya, Queensland QLD 4575
Australia
Princess Alexandra Hospital
Woolloongabba, Queensland QLD 4102
Australia
Monash Health
Clayton, Victoria VIC 3168
Australia
St Vincents Hospital Melbourne
Fitzroy, Victoria VIC 3065
Australia
Peter Maccallum Cancer Centre
Melbourne, Victoria VIC 3000
Australia
The Alfred Hospital
Melbourne, Victoria VIC 3004
Australia
Rockingham Hospital
Cooloongup, Western Australia WA 6168
Australia
Perth Blood Institute
West Perth, Western Australia WA 6005
Australia
Medizinische Universitatsklinik Innsbruck
Innsbruck, 6020
Austria
Medical University Vienna Oncology
Vienna, 1090
Austria
Hanusch Krankenhaus
Vienna, 1140
Austria
Cliniques Universitaires Saint Luc
Brussels, 1200
Belgium
Uz Antwerpen
Edegem, 2650
Belgium
University Hospitals Leuven
Leuven, 3000
Belgium
CETUS
Belo Horizonte, 30110-022
Brazil
Universidade de Campinas Centro de Hematologia E Hemoterapia
Campinas, 13083-878
Brazil
Hospital Erasto Gaertner
Curitiba, 81520-060
Brazil
Complexo Hospitalar de Niteroi
Niterói, 24020-096
Brazil
Irmandade Da Santa Casa de Misericordia Hospital Porto Alegre
Porto Alegre, 90020-090
Brazil
Hospital Sao Lucas
Rio de Janeiro, 22061-080
Brazil
Instituto Dor de Pesquisa E Ensino Rio de Janeiro
Rio de Janeiro, 22281-100
Brazil
Hospital Santa Izabel
Salvador, 40050-410
Brazil
Hospital Samaritano Sao Paulo
São Paulo, 01232-010
Brazil
Instituto Dor de Pesquisa E Ensino Sao Paulo
São Paulo, 01401-004
Brazil
Hospital Nove de Julho Dasa
São Paulo, 01409-001
Brazil
Instituto Brasileiro de Controle Do Cancer
São Paulo, 04014-002
Brazil
Hcfmusp Servico de Hematologia, Hemoterapia E Terapia Celular
São Paulo, 05402-000
Brazil
Hospital Santa Rita de Cassia Afecc
Vitória, 29043-260
Brazil
Arthur Je Child Comprehensive Cancer Centre
Calgary, Alberta T2N 5G2
Canada
Cross Cancer Institute
Edmonton, Alberta T6G 1Z2
Canada
British Columbia Cancer Agency the Vancouver Centre
Vancouver, British Columbia V5Z 4E6
Canada
Cancercare Manitoba
Winnipeg, Manitoba R3E 0V9
Canada
Newfoundland and Labrador Health Services
St. John's, Newfoundland and Labrador A1B 3V6
Canada
The Ottawa Hospital
Ottawa, Ontario K1H 8L6
Canada
Princess Margaret Cancer Centre
Toronto, Ontario M5G 2M9
Canada
Ciusss Nim Hscm
Montreal, Quebec H4J 1C5
Canada
Chu de Quebec Universite Laval, Hopital de Lenfant Jesus, Centre Integre de Cancerologie (Cic)
Québec, G1J 1Z4
Canada
China Japan Friendship Hospital
Beijing, Beijing Municipality 100029
China
The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality 630014
China
Fujian Provincial Hospital
Fuzhou, Fujian 350001
China
The First Affiliated Hospital of Fujian Medical University
Fuzhou, Fujian 350005
China
Fujian Medical University Union Hospitalqishan Branch
Fuzhou, Fujian 350108
China
The First Affiliated Hospital of Xiamen University
Xiamen, Fujian 361003
China
Zhujiang Hospital of Southern Medical University
Guangzhou, Guangdong 510000
China
Guangzhou First Peoples Hospital
Guangzhou, Guangdong 510013
China
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong 510515
China
Guangxi Medical University Cancer Hospital Wuxiang Branch
Nanning, Guangxi 530201
China
The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei 050000
China
Harbin Medical University Cancer Hospital
Harbin, Heilongjiang 150000
China
The First Affiliated Hospital of Xinxiang Medical University
Xinxiang, Henan 453100
China
Taihe Hospital
Shiyan, Hubei 442000
China
Tongji Hospital of Tongji Medical College Huazhong University of Science and Technology
Wuhan, Hubei 430030
China
Xiangya Hospital of Central South University
Changsha, Hunan 410008
China
The Affiliated Hospital of Inner Mongolia Medical University
Hohhot, Inner Mongolia 010050
China
Zhongda Hospital Southeast University
Nanjing, Jiangsu 210009
China
Suzhou Municipal Hospitalbaita Branch
Suzhou, Jiangsu 215001
China
Affiliated Hospital of Jiangnan University South Campus
Wuxi, Jiangsu 214122
China
Northern Jiangsu Peoples Hospital
Yangzhou, Jiangsu 225001
China
Jiangxi Cancer Hospital
Nanchang, Jiangxi 330029
China
The First Hospital of China Medical University
Shenyang, Liaoning 110001
China
Liaoning Cancer Hospital and Institute
Shenyang, Liaoning 110042
China
Shaanxi Provincial Peoples Hospital
Xi'an, Shaanxi 710068
China
Shandong Provincial Hospital
Jinan, Shandong 250000
China
Jining No1 Peoples Hospital West Branch
Jining, Shandong 272000
China
The Affiliated Hospital of Qingdao University Branch West Coast
Qingdao, Shandong 266555
China
Fudan University Shanghai Cancer Center
Shanghai, Shanghai Municipality 200000
China
Affiliated Zhongshan Hospital of Fudan University
Shanghai, Shanghai Municipality 200032
China
West China Hospital, Sichuan University
Chengdu, Sichuan 610041
China
Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciencestuanbo Branch
Tianjin, Tianjin Municipality 301617
China
Sir Run Run Shaw Hospital, Zhejiang University School of Medicinegrand Canal Branch
Hangzhou, Zhejiang 310000
China
The Affiliated Peoples Hospital of Ningbo University
Ningbo, Zhejiang 315040
China
Taizhou Hospital of Zhejiang Province (East)
Taizhou, Zhejiang 317004
China
Fakultni Nemocnice Brno
Brno, 625 00
Czechia
Fakultni Nemocnice Hradec Kralove
Hradec Králové, 500 03
Czechia
Vseobecna Fakultni Nemocnice V Praze
Prague, 10000
Czechia
Ustav Hematologie A Krevni Transfuze (Uhkt)
Prague, 128 00
Czechia
University Hospital of Aalborg
Aalborg, 9000
Denmark
Rigshospitalet
Copenhagen, 2100
Denmark
Odense University Hospital
Odense C, 5000
Denmark
Zealand University Hospital, Roskilde
Roskilde, 4000
Denmark
Chu Clermont Ferrand Therapie Cellulaire and Hematolo
ClermontFerrand, 63100
France
Centre Hospitalier Universitaire Nantes Hotel Dieu
Nantes, 44000
France
Hopital de La Pitie Salpetriere
Paris, 75013
France
Chu Hopital Lyon Sud
PierreBenite, 69495
France
Hopital Robert Debre
Reims, 51100
France
Chu Rennes
Rennes Cedes, 35000
France
Centre Henri Becquerel
Rouen, 76038
France
Iuct Oncopole
Toulouse, 31100
France
Chu Nancy Hopital Brabois
VandoeuvrelesNancy, 54511
France
Osp Kurfuerstendamm
Berlin, 10707
Germany
Uniklinik Koeln (Aoer)
Cologne, 50937
Germany
Gokos Gmbh
Dresden, 01307
Germany
Universitatsklinikum Jena Klinik Fur Innere Medizin Ii
Jena, 07747
Germany
Universitatsklinikum Schleswig Holstein Campus Kiel
Kiel, 24105
Germany
Stauferklinikum Schwabisch Gmund Kliniken Ostalb
Mutlangen, 73557
Germany
Klinikum Der Universitat Munchen Medizinische Klinik Und Poliklinik Iii
München, 81377
Germany
Dietrich Bonhoeffer Klinikum Neubrandenburg
Neubrandenburg, 17036
Germany
Medizinische Universitaetsklinik
Tübingen, 72076
Germany
Universitaetsklinikum Ulm
Ulm, 89081
Germany
Haematologisch Onkologische Schwerpunktpraxis
Würzburg, 97080
Germany
St Jamess Hospital
Dublin, D08 NHY1
Ireland
Mater Misericordiae University Hospital
Dublin, D7
Ireland
University Hospital Galway
Galway, H91 YR71
Ireland
University Hospital Limerick
Limerick, V94F858
Ireland
Azienda Ospedaliera Policlinico Di Bari
Bari, 70124
Italy
Ao Brotzu Ospedale Oncologico Armando Businco
Cagliari, 09121
Italy
Po Grodolico, Aou Policlinico Vittorio Emanuele Di Catania
Catania, 95123
Italy
Azienda Ospedaliero Universitaria Di Ferrara
Ferrara, 44124
Italy
Ospedale San Raffaele
Milan, 20132
Italy
Universita Degli Studi Di Modena Azienda Ospedaliere Policlinco
Modena, 41124
Italy
Asl Salerno Andrea Tortora
Pagani, 84014
Italy
Flevoziekenhuis
Almere Stad, 1315 RA
Netherlands
Rijnstate
Arnhem, 6815 AD
Netherlands
Albert Schweitzer Ziekenhuis
Dordrecht, 3318 AT
Netherlands
Tergooi Mc
Hilversum, 1212 VG
Netherlands
North Shore Hospital
Auckland, 0622
New Zealand
Auckland City Hospital
Auckland, 1023
New Zealand
Wojewodzki Szpital Zespolony Im L Rydygiera W Toruniu
Torun, 87-100
Poland
Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu
Wroclaw, 50-367
Poland
Pusan National University Hospital
Seogu, Busan Gwang'yeogsi 49241
South Korea
National Cancer Center (Korea)
IlsandongGu GoyangSi, Gyeonggi-do 10408
South Korea
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do 13620
South Korea
Samsung Medical Center
GangnamGu, Seoul Teugbyeolsi 06351
South Korea
The Catholic University of Korea, Seoul St Marys Hospital
SeochoGu, Seoul Teugbyeolsi 06591
South Korea
Severance Hospital Yonsei University Health System
SeodaemunGu, Seoul Teugbyeolsi 03722
South Korea
Seoul National University Hospital
Seoul, Seoul Teugbyeolsi 03080
South Korea
Vall D Hebron Institute of Oncology Vhio
Barcelona, 08035
Spain
Hospital Clinic de Barcelona
Barcelona, 08036
Spain
Ico Lhospitalet Hospital Duran I Reynals
LHospitalet de Llobregat, 08908
Spain
Hospital de La Princesa
Madrid, 28006
Spain
Hospital Universitario Infanta Leonor
Madrid, 28031
Spain
Costa Del Sol (Marbella, Malaga)
Marbella, 29603
Spain
Hospital Universitario de Salamanca
Salamanca, 37007
Spain
Hospital Universitario Marques de Valdecilla
Santander, 39008
Spain
Hospital Virgen de Valme (Sevilla)
Seville, 41014
Spain
Sahlgrenska University Hospital Hematology
Gothenburg, 413 46
Sweden
Skanes Universitetssjukhus I Lund
Lund, 221 85
Sweden
Karolinska Universitetssjukhuset Solna
Stockholm, 171 76
Sweden
Uppsala Akademiska Sjukhus
Uppsala, 751 85
Sweden
University Hospitals Dorset Royal Bournemouth Hospital
Bournemouth, BH7 7DW
United Kingdom
Oxford University Hospitals Nhs Trust Churchill Hospital
Headington, OX3 7LE
United Kingdom
St Jamess University Hospital
Leeds, LS9 7TF
United Kingdom
Kings College Hospital
London, SE5 9RS
United Kingdom
Clatterbridge Cancer Centre
Metropolitan Borough of Wirral, CH63 4JY
United Kingdom
Freeman Hospital
Newcastle upon Tyne, NE7 7DN
United Kingdom
Royal Cornwall Hospitalsnhs Trust
Truro, TR1 3LJ
United Kingdom