NCT06966024PHASE1Recruiting
Study of DCC-2812 in Participants With Advanced Genitourinary Cancers
Deciphera Pharmaceuticals, LLC
Start Date
8/27/2025
Completion Date
2/1/2029
Summary
This is a multicenter clinical trial to evaluate the safety and preliminary activity of the selective general control nonderepressible 2 (GCN2) activator DCC-2812 as monotherapy in advanced/metastatic renal cell carcinoma (RCC), urothelial carcinoma, and castration-resistant prostate cancer.
Eligibility Criteria
Age Range: 18 years to No maximum
Key Inclusion Criteria:
* Have confirmed Advanced or Metastatic Renal Cell Carcinoma, Urothelial Cancer, or Castration-Resistant Prostate Cancer
* Able to take oral medication
* If a female is of childbearing potential, must have a negative pregnancy test prior to enrollment and all participants agree to follow the contraception requirements
* Adequate organ function and electrolytes
Key Exclusion Criteria:
* Received any prior anticancer therapy or any investigational therapy within a specified timeframe prior to first dose of DCC-2812
* Impaired cardiac function
* Major surgery within 28 days of the first dose of study drug
Interventions
DRUG
DCC-2812
Conditions
Renal Cell CarcinomaUrothelial CarcinomaCastration-resistant Prostate Cancer
Locations
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United States
University of Michigan
Ann Arbor, Michigan 48109
United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
United States
Vanderbilt- Ingram Cancer Center
Nashville, Tennessee 37232
United States
NEXT Oncology, Austin
Austin, Texas 78758
United States
NEXT Oncology, San Antonio
San Antonio, Texas 78229
United States