NCT06966024PHASE1Recruiting
Study of DCC-2812 in Participants With Advanced Genitourinary Cancers
Deciphera Pharmaceuticals, LLC
Start Date
8/27/2025
Completion Date
2/1/2029
Summary
This is a multicenter clinical trial to evaluate the safety and preliminary activity of the selective general control nonderepressible 2 (GCN2) activator DCC-2812 as monotherapy in advanced/metastatic renal cell carcinoma (RCC), urothelial carcinoma, and castration-resistant prostate cancer.
Eligibility Criteria
Age Range: 18 years to No maximum
Key Inclusion Criteria:
* Have confirmed Advanced or Metastatic Renal Cell Carcinoma, Urothelial Cancer, or Castration-Resistant Prostate Cancer
* Able to take oral medication
* If a female is of childbearing potential, must have a negative pregnancy test prior to enrollment and all participants agree to follow the contraception requirements
* Adequate organ function and electrolytes
Key Exclusion Criteria:
* Received any prior anticancer therapy or any investigational therapy within a specified timeframe prior to first dose of DCC-2812
* Impaired cardiac function
* Major surgery within 28 days of the first dose of study drug
Interventions
DRUG
DCC-2812
Conditions
Renal Cell CarcinomaUrothelial CarcinomaCastration-resistant Prostate Cancer
Locations
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
United States
University of Michigan
Ann Arbor, Michigan 48109
United States
Washington University School of Medicine
St Louis, Missouri 63110
United States
Cleveland Clinic
Cleveland, Ohio 44195
United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
United States
Vanderbilt- Ingram Cancer Center
Nashville, Tennessee 37232
United States
NEXT Oncology, Austin
Austin, Texas 78758
United States
NEXT Oncology, San Antonio
San Antonio, Texas 78229
United States