Back to Trials
NCT06966024PHASE1Recruiting

Study of DCC-2812 in Participants With Advanced Genitourinary Cancers

Deciphera Pharmaceuticals, LLC

Start Date

8/27/2025

Completion Date

2/1/2029

Summary

This is a multicenter clinical trial to evaluate the safety and preliminary activity of the selective general control nonderepressible 2 (GCN2) activator DCC-2812 as monotherapy in advanced/metastatic renal cell carcinoma (RCC), urothelial carcinoma, and castration-resistant prostate cancer.

Eligibility Criteria

Age Range: 18 years to No maximum

Key Inclusion Criteria: * Have confirmed Advanced or Metastatic Renal Cell Carcinoma, Urothelial Cancer, or Castration-Resistant Prostate Cancer * Able to take oral medication * If a female is of childbearing potential, must have a negative pregnancy test prior to enrollment and all participants agree to follow the contraception requirements * Adequate organ function and electrolytes Key Exclusion Criteria: * Received any prior anticancer therapy or any investigational therapy within a specified timeframe prior to first dose of DCC-2812 * Impaired cardiac function * Major surgery within 28 days of the first dose of study drug

Interventions

DRUG

DCC-2812

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Renal Cell CarcinomaUrothelial CarcinomaCastration-resistant Prostate Cancer

Locations

Dana-Farber Cancer Institute

Boston, Massachusetts 02215

United States

University of Michigan

Ann Arbor, Michigan 48109

United States

Fox Chase Cancer Center

Philadelphia, Pennsylvania 19111

United States

Vanderbilt- Ingram Cancer Center

Nashville, Tennessee 37232

United States

NEXT Oncology, Austin

Austin, Texas 78758

United States

NEXT Oncology, San Antonio

San Antonio, Texas 78229

United States