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NCT06968689NARecruitingAccepts Healthy Volunteers

Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain

The University of Texas Health Science Center, Houston

Start Date

6/1/2025

Completion Date

2/29/2028

Summary

The purpose of this study is to assess thalamocortical (TC) connectivity during tonic pressure pain, to evaluate alpha activity during tonic pressure pain and to determine pressure pain ratings by using Electroencephalography (EEG), Functional Magnetic Resonance Imaging (fMRI), Transcranial Alternating Current Stimulation (tACS), sham and Transcranial random noise stimulation (tRNS)

Eligibility Criteria

Age Range: 18 years to 60 years

Inclusion Criteria: * Meet the MRI / EEG screening criteria * Fluent in English Exclusion Criteria: * Current or history of major medical, neurological, or psychiatric illness based on self-report * History of cardiac, respiratory, or nervous system disease that, in the investigator's judgment, precludes participation in the study because of a heightened potential for adverse outcome (for example: asthma or claustrophobia) * History of head trauma * Pregnant or lactating * Presence of any contraindications to MRI scanning (for example: cardiac pacemaker, metal implants, claustrophobia, pregnancy, cannot lie still in fMRI scanner) * Conditions making study participation difficult (e.g., paralysis, psychoses, or other severe psychological problems as per the judgment of a study investigator during Session 1) * Active substance abuse disorders (based on subject self-report)

Interventions

DEVICE

transcranial alternating current stimulation (tACS)

DEVICE

Sham

DEVICE

transcranial random noise stimulation (tRNS)

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Conditions

Pain

Locations

The University of Texas Health Science Center at Houston

Houston, Texas 77030

United States