NCT06968689NARecruitingAccepts Healthy Volunteers
Spatiotemporal Thalamocortical Alterations Underlie Experimental and Chronic Pain
The University of Texas Health Science Center, Houston
Start Date
6/1/2025
Completion Date
2/29/2028
Summary
The purpose of this study is to assess thalamocortical (TC) connectivity during tonic pressure pain, to evaluate alpha activity during tonic pressure pain and to determine pressure pain ratings by using Electroencephalography (EEG), Functional Magnetic Resonance Imaging (fMRI), Transcranial Alternating Current Stimulation (tACS), sham and Transcranial random noise stimulation (tRNS)
Eligibility Criteria
Age Range: 18 years to 60 years
Inclusion Criteria:
* Meet the MRI / EEG screening criteria
* Fluent in English
Exclusion Criteria:
* Current or history of major medical, neurological, or psychiatric illness based on self-report
* History of cardiac, respiratory, or nervous system disease that, in the investigator's judgment, precludes participation in the study because of a heightened potential for adverse outcome (for example: asthma or claustrophobia)
* History of head trauma
* Pregnant or lactating
* Presence of any contraindications to MRI scanning (for example: cardiac pacemaker, metal implants, claustrophobia, pregnancy, cannot lie still in fMRI scanner)
* Conditions making study participation difficult (e.g., paralysis, psychoses, or other severe psychological problems as per the judgment of a study investigator during Session 1)
* Active substance abuse disorders (based on subject self-report)
Interventions
DEVICE
transcranial alternating current stimulation (tACS)
DEVICE
Sham
DEVICE
transcranial random noise stimulation (tRNS)
Conditions
Pain
Locations
The University of Texas Health Science Center at Houston
Houston, Texas 77030
United States