A Study to Evaluate the Safety and Efficacy of BGB-16673 Compared to Pirtobrutinib in Adults With Relapsed/Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma
Start Date
9/4/2025
Completion Date
4/17/2028
Summary
The purpose of this study is to evaluate the efficacy and safety of BGB-16673 alone compared with pirtobrutinib in patients with relapsed or refractory (R/R) chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who had been previously treated with a covalent Bruton tyrosine kinase inhibitor (cBTKi).
Detailed Description
Our company, previously known as BeiGene, is now officially BeOne Medicines. Because some of our older studies were sponsored under the name BeiGene, you may see both names used for this study on this website.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
BGB-16673
Pirtobrutinib
Conditions
Locations
University of Alabama At Birmingham Hospital
Birmingham, Alabama 35294-0004
United States
Mayo Clinic Phoenix
Phoenix, Arizona 85054-4502
United States
Kaiser Permanente Southern California
Irvine, California 92618-3734
United States
University of California San Diego (Ucsd) Moores Cancer Center
La Jolla, California 92093-1503
United States
Cancer and Blood Specialty Clinic
Los Alamitos, California 90720-3302
United States
UCLA Department of Medicine Hematologyoncology
Los Angeles, California 90095-3075
United States
Stanford Cancer Institute
Palo Alto, California 94304-2205
United States
Kaiser Permanente Roseville Medical Center
Roseville, California 95661
United States
Kaiser Permanente Northern California
Vallejo, California 94589-2441
United States
Kaiser Permanente Walnut Creek Medical Center
Walnut Creek, California 94596
United States
Christiana Care
Newark, Delaware 19713-2055
United States
Medstar Georgetown University Hospital
Washington D.C., District of Columbia 20007-2113
United States
Mayo Clinic Jacksonville
Jacksonville, Florida 32224-1865
United States
Cancer Specialists of North Florida
Jacksonville, Florida 32256
United States
Mount Sinai Medical Center Braman Comprehensive Cancer Center
Miami, Florida 33140
United States
University of Chicago Medical Center
Chicago, Illinois 60637-1443
United States
The University of Kansas Cancer Center
Westwood, Kansas 66205-2003
United States
Our Lady of the Lake Hospital
Baton Rouge, Louisiana 70808-4365
United States
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana 70809-3738
United States
Ochsner Clinic Foundation
New Orleans, Louisiana 70121-2429
United States
Dana Farber Cancer Institute
Boston, Massachusetts 02215-5418
United States
Karmanos Cancer Institute
Detroit, Michigan 48201-2013
United States
Mayo Clinic Rochester
Rochester, Minnesota 55905-0001
United States
Washington University School of Medicine
St Louis, Missouri 63110-1010
United States
Titan Health Partners Llc Dba Astera Cancer Care
East Brunswick, New Jersey 08816-4096
United States
John Theurer Cancer Center Hackensack University Medical Center
Hackensack, New Jersey 07601
United States
Columbia University Medical Center
New York, New York 10032
United States
Memorial Sloan Kettering Cancer Center Mskcc
New York, New York 10065-6800
United States
University of Rochester
Rochester, New York 14642-0001
United States
University of North Carolina At Chapel Hill
Chapel Hill, North Carolina 27514-4220
United States
Atrium Health Levine Cancer Institute (Lci)
Charlotte, North Carolina 28204-2990
United States
Duke University Medical Center
Durham, North Carolina 27705-3976
United States
Atrium Health Wake Forest Baptist
Winston-Salem, North Carolina 27157
United States
Dayton Physician Network
Dayton, Ohio 45415
United States
Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111-2434
United States
Tennessee Oncology, Pllc Nashville
Nashville, Tennessee 37203
United States
Md Anderson Cancer Center
Houston, Texas 77030-3907
United States
Blue Ridge Cancer Care (Oncology and Hematology Associates of Southwest Virginia)
Roanoke, Virginia 24014
United States
Fred Hutchinson Cancer Research Center
Seattle, Washington 98109-4433
United States
Summit Cancer Centers
Spokane, Washington 99208-1129
United States
Northwest Medical Specialties
Tacoma, Washington 98405
United States
Gunderson Health System
La Crosse, Wisconsin 54601-5467
United States
FUNDALEU
Caba, CP1114
Argentina
Centro Oncologico de Integracion Regional (Coir)
Mendoza, M5500
Argentina
Concord Repatriation General Hospital
Concord, New South Wales NSW 2139
Australia
St George Private Hospital
Kogarah, New South Wales 2217
Australia
Westmead Private Hospital
Westmead, New South Wales 2145
Australia
Pindara Private Hospital
Benowa, Queensland QLD 4217
Australia
Sunshine Coast Hospital and Health Service
Birtinya, Queensland QLD 4575
Australia
John Flynn Private Hospital
Tugun, Queensland QLD 4224
Australia
Flinders Medical Centre
Bedford PK, South Australia SA 5042
Australia
St Vincents Hospital Melbourne
Fitzroy, Victoria VIC 3065
Australia
Peninsula Private Hospital
Frankston, Victoria VIC 3199
Australia
Austin Health
Heidelberg, Victoria VIC 3084
Australia
Cabrini Hospital Malvern
Malvern, Victoria VIC 3144
Australia
Peter Maccallum Cancer Centre
Melbourne, Victoria VIC 3000
Australia
The Alfred Hospital
Melbourne, Victoria VIC 3004
Australia
Linear Clinical Research
Nedlands, Western Australia WA 6009
Australia
Medical University Graz
Graz, 8036
Austria
Medizinische Universitatsklinik Innsbruck
Innsbruck, 6020
Austria
Ordensklinikum Linz Gmbh Elisabethinen
Linz, 4020
Austria
Universitatsklinik Fur Innere Medizin Iii Universitatsklinikum Der Pmu Landeskrankenhaus Salzburg
Salzburg, 5020
Austria
Uk St Poelten
Sankt Pölten, 3100
Austria
Institut Jules Bordet
Anderlecht, 1070
Belgium
UZ GENT
Ghent, 9000
Belgium
Az Groeninge Campus Loofstraat
Kortrijk, 8500
Belgium
Chc Montlegia
Liège, 4000
Belgium
Chu de Liege
Liège, 4000
Belgium
Az Sint Maarten
Mechelen, 2800
Belgium
Chu Ucl Namur
Yvoir, 5530
Belgium
Centro de Pesquisa Clinica Dom Bosco Ltda
Araçatuba, 16015-150
Brazil
Ictr Instituto Do Cancer E Transplante de Curitiba
Curitiba, 80510-130
Brazil
Hospital de Clinicas de Goiania Ufg
Goiânia, 74605-020
Brazil
Inca Instituto Nacional de Cancer
Rio de Janeiro, 20231-050
Brazil
Ensino E Terapia de Inovacao Clinica Amo Etica
Salvador, 41950-640
Brazil
Hospital Nove de Julho Dasa
São Paulo, 01409-001
Brazil
Hcfmusp Hospital Das Clinicas Da Faculdade de Medicina Da Universidade de Sao Paulo
São Paulo, 05403-010
Brazil
Peking Union Medical College Hospital
Beijing, Beijing Municipality 100730
China
Fujian Medical University Union Hospital
Fuzhou, Fujian 350001
China
Sun Yat Sen University Cancer Center
Guangzhou, Guangdong 510060
China
Jiangmen Central Hospital
Jiangmen, Guangdong 529030
China
The Fourth Hospital of Hebei Medical University East Branch
Shijiazhuang, Hebei 050035
China
Xuchang Central Hospitalluminghu Branch
Xuchang, Henan 461000
China
Henan Cancer Hospital
Zhengzhou, Henan 450000
China
Union Hospital, Tongji Medical College, Huazhong University of Science and Technologychegu Branch
Wuhan, Hubei 430056
China
Affiliated Hospital of Nantong University
Nantong, Jiangsu 201203
China
The First Affiliated Hospital of Soochow University
Suzhou, Jiangsu 215006
China
Wuxi Peoples Hospital
Wuxi, Jiangsu 214023
China
The Affiliated Hospital of Xuzhou Medical University
Xuzhou, Jiangsu 221000
China
The Second Affiliated Hospital of Nanchang University
Nanchang, Jiangxi 330006
China
Qinghai University Affiliated Hospital
Xining, Qinghai 810001
China
The Second Affiliated Hospital of Xian Jiaotong University
Xi'an, Shaanxi 710004
China
Binzhou Medical University Hospital
Binzhou, Shandong 256603
China
Taian City Central Hospital
Taian, Shandong 271099
China
Renji Hospital Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality 200000
China
Shanxi Bethune Hospital
Taiyuan, Shanxi 030032
China
Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital
Chengdu, Sichuan 610071
China
Dazhou Central Hospital
Dazhou, Sichuan 635099
China
The Affiliated Hospital of Southwest Medical University
Luzhou, Sichuan 646099
China
Institute of Hematology and Hospital of Blood Disease
Tianjin, Tianjin Municipality 300020
China
First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan 650032
China
The First Affiliated Hospital of Ningbo University
Ningbo, Zhejiang 315010
China
The First Affiliated Hospital of Wenzhou Medical University
Wenzhou, Zhejiang 325000
China
Centre de Lutte Contre Le Cancer Institut Bergonie
Bordeaux, 33000
France
Hopital Estaing
ClermontFerrand, 63100
France
Centre Hospitalier Universitaire Nantes Hotel Dieu
Nantes, 44000
France
Hopital Saint Louis
Paris, 75010
France
Centre Henri Becquerel
Rouen, 76038
France
Iuc Toulouse Oncopole
Toulouse, 31100
France
Chu Tours Hopital Bretonneau
Tours, 37000
France
Chu Nancy Hopital Brabois
VandoeuvrelesNancy, 54511
France
St Josef Hospital Klinikum Der Ruhr Universitat Bochum
Bochum, 44791
Germany
Universitatsklinikum Bonn
Bonn, 53127
Germany
Uniklinik Koeln (Aoer)
Cologne, 50937
Germany
Gemeinschaftspraxis Fur Hamatologie Und Onkologie Dortmund
Dortmund, 44309
Germany
Stadtisches Klinikum Karlsruhe
Karlsruhe, 76133
Germany
Mvz Fur Hamatologie Und Onkologie Lubeckgmbh
Lübeck, 23562
Germany
Universitaetsklinikum Ulm
Ulm, 89081
Germany
Gemeinschaftspraxis Fuer Haematologie Und Onkologie Westerstede
Westerstede, 26655
Germany
Bnai Zion Medical Center
Haifa, 31048
Israel
Shaare Zedek Medical Center
Jerusalem, 9103102
Israel
Hadassah University Hospital Ein Kerem
Jerusalem, 91120
Israel
Meir Medical Center
KfarSava, 4428164
Israel
Rabin Medical Center
Petah Tikva, 49100
Israel
Sheba Medical Center
Ramat Gan, 5262100
Israel
Sourasky Tel Aviv Medical Center
Tel Aviv, 6423906
Israel
Policlinico Sorsola Malpighi, Aou Di Bologna
Bologna, 40138
Italy
Ospedale San Raffaele
Milan, 20132
Italy
Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
Milan, 20162
Italy
Azienda Ospedaliera Di Padova
Padova, 35128
Italy
Aichi Cancer Center Hospital Clinical Oncology
Nagoya, Aichi-ken 464-8681
Japan
Japanese Red Cross Aichi Medical Center Nagoya Daiichi Hospital
Nakamuraku, Aichi-ken 453-8511
Japan
Matsuyama Red Cross Hospital
Matsuyama, Ehime 790 8524
Japan
Fukushima Medical University Hospital
Fukushima, Fukushima 960-1295
Japan
Hiroshima Red Cross Hospital and Atomic Bomb Survivors Hospital
Hiroshima, Hiroshima 730-8619
Japan
Aiiku Hospital
Sapporo, Hokkaido 064-0804
Japan
Kochi Medical School Hospital
Nankoku, Kochi 783-8505
Japan
Japanese Red Cross Kyoto Daini Hospital
Kyotoshi, Kyoto 602-8026
Japan
Okayama University Hospital
Okayama, Okayama-ken 700-8558
Japan
Kindai University Hospital
Sakai, Osaka 590-0197
Japan
Dokkyo Medical University Saitama Medical Center
Koshigaya, Saitama 503-8502
Japan
Tokyo Metropolitan Komagome Hospital
Bunkyoku, Tokyo 113-8677
Japan
Cancer Institute Hospital of Jfcr
Kotoku, Tokyo 135-8550
Japan
National Hospital Organization (Nho) Disaster Medical Center
Tachikawashi, Tokyo 190-0014
Japan
Yamagata University Hospital
Yamagata, Yamagata 990-9585
Japan
Kumamoto University Hospital
Kumamoto, 860-8556
Japan
Osaka Metropolitan University Hospital
Osaka, 545-8586
Japan
Oita Prefectural Hospital
Ōita, 870-8511
Japan
Centro de Investigacion Clinica Gramel
México, 3720
Mexico
Christus Latam Hub Center of Excellence and Innovation Sc
Monterrey, 64000
Mexico
Centro de Investigacion Clinica de Oaxaca
Oaxaca City, 68020
Mexico
Centro Hemato Oncologico Privado de Toluca
Toluca, 50120
Mexico
Albert Schweitzer Ziekenhuis
Dordrecht, 3318 AT
Netherlands
Catharina Hospital
EJ Eindhoven, 5623
Netherlands
Groene Hart Hospital
Gouda, 2803
Netherlands
University of Medical Center Groningen (Umcg)
Groningen, 9713 GZ
Netherlands
Canisius Wilhelmina Ziekenhuis
Nijmegen, 6532 SZ
Netherlands
Universitair Medisch Centrum Utrecht
Utrecht, 3584 CX
Netherlands
North Shore Hospital
Auckland, 0622
New Zealand
Tauranga Hospital
Tauranga, 3112
New Zealand
Wellington Regional Hospital (Ccdhb)
Wellington, 6021
New Zealand
Copernicus Podmiot Leczniczy Sp Z Oo Wojewodzkie Centrum Onkologii
Gdansk, 80-219
Poland
Swietokrzyskie Centrum Onkologii Samodzielny Publiczny Zaklad Opieki Zdrowotnej W Kielcach
Kielce, 25-734
Poland
Wojewodzkie Wielospecjalistyczne Centrum Onkologii I Traumatologii Im M Kopernika W Lodzi
Lodz, 93-513
Poland
Uniwersytecki Szpital Kliniczny Nr 1 W Lublinie Klinika Hematoonkologii
Lublin, 20-081
Poland
Szpital Kliniczny Mswia Z Warmisko Mazurskim Centrum Onkologii
Olsztyn, 10-228
Poland
Wojewodzki Szpital Zespolony Im L Rydygiera W Toruniu
Torun, 87-100
Poland
Narodowy Instytut Onkologii Im Marii Sklodowskiej Curie W Warszawie
Warsaw, 02-781
Poland
Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu
Wroclaw, 50-367
Poland
Auxilio Mutuo Cancer Center
San Juan, 00917
Puerto Rico
Coltea Clinical Hospital
Bucharest, 30171
Romania
Institutul Oncologic Prof Dr Ion Chiricuta Cluj Napoca
ClujNapoca, 400015
Romania
Institutul Regional de Oncologie Iasi
Iași, 700483
Romania
Singapore General Hospital
Singapore, 168582
Singapore
Tan Tock Seng Hospital Haematology
Singapore, 308433
Singapore
Pusan National University Hospital
Seogu, Busan Gwang'yeogsi 49241
South Korea
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do 13620
South Korea
Gyeongsang National University Hospital
Jinju, Gyeongsangnam-do 52727
South Korea
The Catholic University of Korea, Seoul St Marys Hospital
SeochoGu, Seoul Teugbyeolsi 06591
South Korea
Severance Hospital Yonsei University Health System
SeodaemunGu, Seoul Teugbyeolsi 03722
South Korea
Seoul National University Hospital
Seoul, Seoul Teugbyeolsi 03080
South Korea
Ico Badalona
Badalona, 08916
Spain
Hospital Universitario de Burgos
Burgos, 09006
Spain
Hospital Universitario de Gran Canaria Dr Negrin
Las Palmas de Gran Canaria, 35010
Spain
Hospital Universitario Fundacion Jimenez Diaz
Madrid, 28040
Spain
Hospital Universitario Puerta de Hierro Majadahonda
Majadahonda, 28222
Spain
Hospital Universitari Son Espases
Palma de Mallorca, 07120
Spain
Hospital Universitario Virgen Del Rocio
Seville, 41013
Spain
Sahlgrenska Universitetssjukhuset
Gothenburg, 413 46
Sweden
Karolinska Universitetssjukhuset Solna
Stockholm, 171 76
Sweden
Inselspital Bern (Inselspital, Universitatsspital Bern)
Bern, 3010
Switzerland
Universitatsspital Zurich
Zurich, 8091
Switzerland
University Hospitals Sussex Nhs Foundation Trust
Brighton, BN2 5BE
United Kingdom
Kent and Canterbury Hospital
Canterbury, CT1 3NG
United Kingdom
Norfolk and Norwich University Hospitals Nhs Foundation Trust
Norwich, NR4 7UY
United Kingdom
Spire Leeds Healthcare Spire Leeds Hospital
Roundhay, LS8 1NT
United Kingdom
Salisbury Foundation Trust
Salisbury, SP2 8BJ
United Kingdom