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NCT07011914Recruiting

Care in Multiple Sclerosis (MS)

NYU Langone Health

Start Date

10/23/2025

Completion Date

6/30/2029

Summary

This study is structured around three main aims. In Aim 1, investigators will conduct community-based participatory research (CBPR) to develop culturally tailored methods to assess childhood adversity in multiple sclerosis (MS). Aim 2 will investigate the impact of childhood adversity on MS outcomes among individuals with relapsing-remitting MS (RRMS), among whom 70% belong to a group historically under-represented in MS research: Black, Hispanic, or poverty-impacted. Aim 2 procedures involve two visits that include a research blood draw and an MRI scan. In Aim 3, investigators will conduct interviews and surveys to explore environmental and social factors affecting quality of life for minority MS patients.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: Aim 1 - * aged ≥18-29 years * diagnosis of RRMS (Fulfill international criteria for relapsing remitting (RRMS)) * 70% self-identifying as a Black, Hispanic, or poverty-impacted (up to 138% of the federal poverty level) individual,and * fluent in English or Spanish. Aim 2 - * aged ≥18-29 years * diagnosis of RRMS (Fulfill international criteria for relapsing remitting (RRMS)) * 70% self-identifying as a Black, Hispanic, or poverty impacted, and * fluent reading in English or Spanish * Pediatric onset MS (MS onset before age 18 and age at time of enrollment is 18-25) OR adult-onset MS (MS onset at age 18 or older and age at time of enrollment is 19-29) * Disease duration below 8 years Aim 3 - Aim 3 will enroll the first 20 participants from Aim 2 who meet the following criteria: * completed at least 80% of study data in the cross-sectional study/Aim 2. * a total of 70% must self-identify as Black, Hispanic, or meet criteria for poverty impacted. * interviews will be evenly split between participants with high (top quartile) and low (bottom quartile) of PROMIS-10 scores. Exclusion Criteria: * Primary or Secondary Progressive MS * Inability to consent. * MS relapse within 30 days prior to study entry * Other major neurologic or psychiatric illness

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Conditions

Multiple Sclerosis

Locations

University of Alabama at Birmingham

Birmingham, Alabama 35294

United States

University of California, San Francisco

San Francisco, California 94158

United States

University of Colorado Denver

Aurora, Colorado 80045

United States

Massachusetts General Hospital

Boston, Massachusetts 02114

United States

Cleveland Clinic

Cleveland, Ohio 44195

United States

Baylor College of Medicine

Houston, Texas 77030

United States