A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Episodic Migraine
Start Date
8/21/2025
Completion Date
10/1/2027
Summary
In this clinical trial, participants with episodic migraine will receive injections with Xeomin or Placebo into muscles of the head and neck. The purpose is to measure the change in monthly migraine days with Xeomin injections compared to Placebo injections. Trial details include: * Trial duration: 52 to 55 weeks; * Screening period: 4 to 5 weeks; * Treatment duration: 4 treatments, each about 12 weeks apart; and * Visit frequency: about every 4 weeks, 14 visits in total. The first and last visit and the 4 treatment visits are on-site, the other 8 visits are remote by phone / video call.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Xeomin
Placebo
Conditions
Locations
TrialSphere Corp, Merz Investigational Site #0010513
Chandler, Arizona 85286
United States
Arizona Neuroscience Research, Merz Investigational Site #0010521
Phoenix, Arizona 85018
United States
Baptist Health Medical Center, Merz Investigational Site #0010520
Little Rock, Arkansas 72205
United States
Chemidox Clinical Trials Inc, Merz Investigational Site #0010488
Lancaster, California 93534
United States
Clinical Research Institute, Merz Investigational Site #0010487
Los Angeles, California 90048
United States
Clinical Trials Management Services, Merz Investigational Site #0010526
Thousand Oaks, California 91360
United States
BNL Health Inc., Merz Investigational Site #0010489
Torrance, California 90505
United States
Hasbani Neurology, Merz Investigational Site #0010509
New Haven, Connecticut 06511
United States
Yale Center for Clinical Investigations, Merz Investigational Site #0010527
New Haven, Connecticut 06519
United States
New England Institute Neurology and Headache, Merz Investigational Site #0010441
Stamford, Connecticut 06905
United States
Northwest Florida Clinical Research Group, Merz Investigational Site #0010286
Gulf Breeze, Florida 32561
United States
Nexus Clinical Research Center, Merz Investigational Site #0010514
Homestead, Florida 33030
United States
Jacksonville Center for Clinical Research, Merz Investigational Site #0010515
Jacksonville, Florida 32216
United States
Clinical Research of Central Florida, Merz Investigational Site #0010532
Lakeland, Florida 33805
United States
American Research Institute, Merz Investigational Site #0010492
Miami, Florida 33157
United States
Premiere Research Institute at Palm Beach Neurology, Merz Investigational Site #0010499
West Palm Beach, Florida 33407
United States
Accel Research - NeuroStudies, Merz Investigational Site #0010523
Decatur, Georgia 30030
United States
Hawaii Pacific Neuroscience, Merz Investigational Site #0010510
Honolulu, Hawaii 96817
United States
Kansas Institute of Research,, Merz Investigational Site #0010495
Overland Park, Kansas 66211
United States
Crescent City Headache and Neurology Center, Merz Investigational Site #0010517
Chalmette, Louisiana 70043
United States
DelRicht Clinical Research,, Merz Investigational Site #0010518
New Orleans, Louisiana 70115
United States
Sinai Hospital of Baltimore, Merz Investigational Site #0010505
Baltimore, Maryland 21215
United States
MedVadis Research, Merz Investigational Site #0010524
Waltham, Massachusetts 02451
United States
Mass Institute of Clinical Research, Merz Investigational Site #0010506
Westborough, Massachusetts 01581
United States
Vida Clinical Studies, Merz Investigational Site #0010498
Dearborn Heights, Michigan 48127
United States
Quest Research Institute, Merz Investigational Site #0010484
Farmington Hills, Michigan 48334
United States
StudyMetrix Research, Merz Investigational Site #0010530
City of Saint Peters, Missouri 63303
United States
Quality Clinical Research, Merz Investigational Site #0010522
Omaha, Nebraska 68114
United States
Dent Neurosciences Research Center, Merz Investigational Site #0010486
Amherst, New York 14226
United States
Integrative Clinical Trials, Merz Investigational Site #0010496
Brooklyn, New York 11229
United States
New York Neurology Associates, Merz Investigational Site #0010500
New York, New York 10003
United States
True North Neurology, Merz Investigational Site #0010508
Port Jefferson Station, New York 11776
United States
Rochester Clinical Research, Merz Investigational Site #0010512
Rochester, New York 14609
United States
Upstate Clinical Research Associates, Merz Investigational Site #0010485
Williamsville, New York 14221
United States
Dayton Center for Neurological Disorders, Merz Investigational Site #0010531
Centerville, Ohio 45459
United States
Headache Center of Hope, Merz Investigational Site #0010528
Cincinnati, Ohio 45236
United States
University Hospitals Cleveland Medical Center, Merz Investigational Site #0010491
Cleveland, Ohio 44106
United States
Tekton Research, Merz Investigational Site #0010494
Edmond, Oklahoma 73013
United States
Thomas Jefferson University, Merz Investigational Site #0010354
Philadelphia, Pennsylvania 19107
United States
Coastal Neurology, Merz Investigational Site #0010503
Port Royal, South Carolina 29935
United States
Alina Clinical Trials, Merz Investigational Site #0010511
Dallas, Texas 75209
United States
Lone Star Neurology, Merz Investigational Site #0010497
Frisco, Texas 75035
United States
MedStar Health - Department of Neurology, Merz Investigational Site #0010231
McLean, Virginia 22101
United States
Gershon Pain Specialists, Merz Investigational Site #0010519
Virginia Beach, Virginia 23454
United States
EvergreenHealth Research Department, Merz Investigational Site #0010516
Kirkland, Washington 98034
United States
Gundersen Health System, Merz Investigational Site #0010507
La Crosse, Wisconsin 54601
United States
Medical University of Innsbruck, Merz Investigational Site #0430043
Innsbruck, 6020
Austria
Klinikum Klagenfurt Am Wörthersee, Merz Investigational Site #0430042
Klagenfurt, 9020
Austria
Genge Partners Inc., Merz Investigational Site #0010525
Montreal, H4A 3T2
Canada
CaRe Clinic, Merz Investigational Site #0010504
Red Deer, T4P 1K4
Canada
Pratia Brno, Merz Investigational Site #4200053
Brno, 602 00
Czechia
Fakultní nemocnice Hradec Králové, Merz Investigational Site #4200056
Hradec Králové, 500 05
Czechia
CLINTRIAL, Merz Investigational Site #4200052
Prague, 100 00
Czechia
Axon Clinical, Merz Investigational Site #4200051
Prague, 150 00
Czechia
Neuropsychiatrie, Merz Investigational Site #4200054
Prague, 160 00
Czechia
Rigshospitalet-Glostrup, Merz Investigational Site #0450006
Glostrup Municipality, 2600
Denmark
CHU Clermont Ferrand, Merz Investigational Site #0330026
Clermont-Ferrand, 63000
France
Centre Hospitalier Universitaire Grenoble Alpes, Merz Investigational Site #0330069
La Tronche, 38700
France
CHU Nantes, Merz Investigational Site #0330068
Nantes, 44093
France
Charité - Universitätsmedizin Berlin, Merz Investigational Site #0490398
Berlin, 10117
Germany
Kopfschmerzzentrum Frankfurt, Merz Investigational Site #0490394
Frankfurt, 65929
Germany
Universitätsmedizin Greifswald, Merz Investigational Site #0490397
Greifswald, 17475
Germany
Vitos Orthopädische Klinik Kassel, Merz Investigational Site #0490396
Kassel, 34131
Germany
Schmerzklinik Kiel GmbH, Merz Investigational Site #0490395
Kiel, 24149
Germany
Azienda Ospedaliera Universitaria Careggi, Merz Investigational Site #0390023
Florence, 50134
Italy
Ospedale San Raffaele, Merz Investigational Site #0390027
Milan, 20132
Italy
Istituto Auxologico Italiano, Merz Investigational Site #0390024
Milan, 20149
Italy
Fondazione Istituto Neurologico Nazionale Casimiro Mondino, Merz Investigational Site #0390025
Pavia, 27100
Italy
IRCCS San Raffaele Roma, Merz Investigational Site #0390026
Roma, 00166
Italy
Centrum Medyczne Neuromed, Merz Investigational Site #0480117
Bydgoszcz, 85-163
Poland
AthleticoMed, Merz Investigational Site #0480127
Bydgoszcz, 85-752
Poland
ETG Debica, Merz Investigational Site #0480121
Dębica, 39-200
Poland
Centrum Medyczne Pratia Gdynia, Merz Investigational Site #0480126
Gdynia, 81-338
Poland
Silmedic Sp. z o.o., Merz Investigational Site #0480115
Katowice, 40-282
Poland
Jan Banach Research Spot, Merz Investigational Site #0480059
Krakow, 30-539
Poland
Pratia MCM, Merz Investigational Site #0480087
Krakow, 30-727
Poland
FutureMeds, Merz Investigational Site #0480125
Krakow, 31-501
Poland
Krakowska Akademia Neurologii, Merz Investigational Site #0480031
Krakow, 31-505
Poland
Neurocor, Merz Investigational Site #0480119
Krakow, 31-870
Poland
Clinirem, Merz Investigational Site #0480128
Lublin, 20-064
Poland
ETG Lublin, Merz Investigational Site #0480118
Lublin, 20-412
Poland
Indywidualna Praktyka Lekarska Dr hab. Med. Anna Szczepańska-Szerej, Merz Investigational Site #0480096
Lublin, 20-582
Poland
Instytut Zdrowia dr Boczarska-Jedynak, Merz Investigational Site #0480103
Oświęcim, 32-600
Poland
Solumed Centrum Medyczne, Merz Investigational Site #0480122
Poznan, 60-529
Poland
ETG Neuroscience, Merz Investigational Site #0480116
Warsaw, 02-677
Poland
MIGRE Polskie Centrum Leczenia Migreny, Merz Investigational Site #0480124
Wroclaw, 52-210
Poland
Futuremeds, Merz Investigational Site #0480123
Wroclaw, 53-673
Poland
ETG Zamosc, Merz Investigational Site #0480120
Zamość, 22-400
Poland
MUDr. Beáta Dupejová, neurologická ambulancia, Merz Investigational Site #4210002
Banská Bystrica, 974 04
Slovakia
KONZÍLIUM, Merz Investigational Site #4210011
Dubnica nad Váhom, 018 41
Slovakia
NEURES, Merz Investigational Site #4210006
Krompachy, 053 42
Slovakia
Liptovská nemocnica s poliklinikou, Merz Investigational Site #4210013
Liptovský Mikuláš, 031 23
Slovakia
Hospital Clinic de Barcelona-Hospital Plato, Merz Investigational Site #0340047
Barcelona, 08006
Spain
Hospital Universitari Vall d'Hebron, Merz Investigational Site #0340006
Barcelona, 08035
Spain
Hospital Universitario 12 de Octubre, Merz Investigational Site #0340055
Madrid, 28041
Spain
Hospital Universitario La Paz, Merz Investigational Site #0340007
Madrid, 28046
Spain
Campus Blua Sanitas Valdebebas Hospital, Merz Investigational Site #0340057
Madrid, 28055
Spain
Hospital Regional Universitario de Malaga, Merz Investigational Site #0340050
Málaga, 29010
Spain
Hospital Universitario Virgen de la Victoria, Merz Investigational Site #0340056
Málaga, 29010
Spain
Hospital Vithas Malaga, Merz Investigational Site #0340054
Málaga, 29016
Spain
Hospital Universitario Virgen del Rocio, Merz Investigational Site #0340046
Seville, 41013
Spain
Consorci Sanitari de Terrassa, Merz Investigational Site #0340051
Terrassa, 08227
Spain
Hospital Universitari i Politecnic La Fe de Valencia, Merz Investigational Site #0340049
Valencia, 46026
Spain
Complejo Hospitalario Universitario de Vigo, Merz Investigational Site #0340052
Vigo, 36312
Spain
Hospital Viamed Montecanal, Merz Investigational Site #0340053
Zaragoza, 50012
Spain
Inselspital Bern, Merz Investigational Site #0410003
Bern, 3010
Switzerland
Kopfwehzentrum Hirslanden, Merz Investigational Site #0410017
Zollikon, 8702
Switzerland
Royal Stoke University Hospital, Merz Investigational Site #0440048
Stoke-on-Trent, ST4 6QG
United Kingdom