NCT07023887Recruiting
Prospective Study of EXErcise Regimens After Treatment for Breast Cancer for Hypertrophy and Conditioning
Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Start Date
5/21/2025
Completion Date
10/15/2026
Summary
This study investigates the impact of four standard of care, monitored group exercise regimens (resistance training) on conditioning and hypertrophy in women previously treated for breast cancer. The study will compare two conditioning regimens (6-12-25 and 8x8) and two hypertrophy regimens (5/5/5 cluster sets and double training) to assess changes in VO2 max, muscle mass, and fat mass.
Eligibility Criteria
Age Range: 20 years to 89 years
Inclusion Criteria:
1. Age 20-89 years
2. Women prescribed exercise as a Standard of Care
3. Women with a biopsy proven diagnosis of ductal carcinoma in situ (DCIS) or invasive carcinoma of the breast
4. Women must have undergone treatment for breast cancer, including one or more of the following: surgery, radiation therapy, chemotherapy, immunotherapy, or hormonal therapy.
5. Women undergoing active chemotherapy are not allowed on study. Immunotherapy or targeted agent usage is allowed.
6. Women with \> 6 months of resistance training experience under expert guidance by a CSCS
Exclusion Criteria:
1. Any current treatment with cytotoxic chemotherapy for breast cancer
2. Inability to safely engage in group sessions of resistance training as deemed by study Pl
3. Severe arthritic, joint, cardiovascular, or musculoskeletal condition deemed by Pl to be unsafe to engage in resistance training
4. Beta blocker or GLP-1 inhibitor medications
5. Pregnant women
6. Males
Interventions
OTHER
6-12-25 Training Regimen
OTHER
8x8 Training Regimen
OTHER
5/5/5 Cluster Set Training Regimen
OTHER
Double Training Regimen
Conditions
CancerBreast Cancer
Locations
Allegheny General Hospital
Pittsburgh, Pennsylvania 15212
United States