A Neurosensory Account of Anxiety and Stress (Study 2)
Start Date
7/3/2025
Completion Date
7/1/2026
Summary
This study will take a basic neuroscience approach to investigate pathological mechanisms underlying PTSD. Additionally, the study aims to identify how Transcranial Alternating Current Stimulation (tACS) brain stimulation can modulate and correct neural networks and related emotions of anxious arousal and hypervigilance, with the goal of assessing tACS brain stimulation technology as a novel intervention for symptoms of anxiety.
Detailed Description
This study includes experiments 2 \& 3 to address Aim 3--threat-related SC disinhibition and Sensory-Prefrontal-cortex-Amygdala (SPA) pathology in PTSD. The goal of this study is to develop and test a novel pathophysiology of PTSD by integrating sensory cortical (SC) and amygdala-prefrontal cortex (PFC) dysfunctions into a tripartite Sensory-Prefrontal-Cortex-Amygdala (SPA) model. The investigators will recruit 80 healthy subjects and 80 patients with PTSD in a randomized, double-blind, controlled design, where they be randomly assigned to 1) Transcranial Alternating Current Stimulation (tACS) at individual alpha peak frequency (active condition); 2) sham control tACS; or 3) active control, which will be transcranial random noise stimulation (tRNS) (random frequency 1-200 Hz). Simultaneous EEG/fMRI recordings and behavioral responses will be acquired before and after tACS/sham tACS/tRNS stimulation. During tACS/sham tACS/tRNS stimulation, stimulation electrodes will be placed inside the holders of an EEG cap attached to the head of the participant. Experiments 2 \& 3 include a visual search task and an olfactory detection task, respectively, and both experiments include threat and neutral stimuli.
Eligibility Criteria
Age Range: 18 years to 50 years
Interventions
Transcranial Alternating Current Stimulation (tACS)
Sham for Transcranial Alternating Current Stimulation (tACS)
Transcranial Random Noise stimulation (tRNS)
Conditions
Locations
The University of Texas Health Science Center at Houston
Houston, Texas 77030
United States