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NCT07114510NARecruiting

Optimal Ventilation for Cardiac Arrest

Children's Hospital of Philadelphia

Start Date

10/1/2025

Completion Date

3/31/2030

Summary

Pediatric cardiac arrest is a life-threatening problem affecting \>15,000 hospitalized children each year. Less than half of these children survive to hospital discharge, and neurologic morbidity is common among survivors. The objective of this study is to evaluate the effectiveness of the OPTI-VENT bundle to improve survival to discharge with favorable neurological outcome (Pediatric Cerebral Performance Category Score 1-2 or no change from baseline) among children receiving at least 1 minute of CPR.

Eligibility Criteria

Age Range: No minimum to 18 years

Inclusion Criteria: * Invasive airway in place at the start of CPR or airway placed within the first 5 minutes * Received at least 1 minute of CPR. Exclusion Criteria: * Lack of commitment to aggressive ICU therapies (e.g., CPR performed as part of end-of-life care. * Brain death determination prior to the CPR event. * Out-of-hospital cardiac arrest was the reason for initial admission to the hospital (known poor outcomes). * Supported by Veno-Arterial Extra Corporeal Membrane Oxygenation at the start of CPR

Interventions

OTHER

OPTI-VENT Bundle

OTHER

Transition

OTHER

None - control

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Conditions

Cardiac Arrest (CA)

Locations

CHOC

Orange, California 92868

United States

Lucile Packard Children's Hospital Stanford

Palo Alto, California 94304

United States

Children's Hospital Colorado

Denver, Colorado 80045

United States

Nemours Children's Health

Wilmington, Delaware 19803

United States

Children's Healthcare of Atlanta

Atlanta, Georgia 30303

United States

Riley Children's Health

Indianapolis, Indiana 46202

United States

Stead Family Children's Hospital

Iowa City, Iowa 52242

United States

Boston Children's Hospital

Boston, Massachusetts 02115

United States

Washington University in St. Louis

St Louis, Missouri 63110

United States

Cohen Children's Medical Center

New Hyde Park, New York 11040

United States

UNC Children's Hospital

Chapel Hill, North Carolina 27599

United States

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio 45229

United States

Nationwide Children's Hospital

Columbus, Ohio 43205

United States

Children's Hospital of Philadelphia

Philadelphia, Pennsylvania 19104

United States

Dell Children's Medical Center

Austin, Texas 78723

United States

Medical City Children's Hospital

Dallas, Texas 75230

United States

UT Southwestern Medical Center

Dallas, Texas 75390

United States

Children's Hospital of Richmond at VCU

Richmond, Virginia 23219

United States

Seattle Children's

Seattle, Washington 98105

United States

Children's Wisconsin

Milwaukee, Wisconsin 53226

United States