Neuromodulation + Prolonged Exposure Therapy: Evaluation of a Technology-Enhanced, Integrated Treatment for Pain and PTSD
Start Date
7/1/2025
Completion Date
6/30/2029
Summary
The purpose of this study is to examine comparative effectiveness of two home-based telemedicine delivered interventions: transcranial Direct Current Stimulation (tDCS) combined with Massed Prolonged Exposure (Massed-PE) vs. Sham tDCS combined with Massed PE, focusing on pain and PTSD outcomes, to determine the comparative effectiveness of the two interventions on process outcomes of patient satisfaction, treatment attrition, and treatment compliance and to explore changes in blood biomarkers associated with stress and inflammatory processes related to pain and PTSD symptom improvements following treatment.
Eligibility Criteria
Age Range: 21 years to No maximum
Interventions
Transcranial Direct Current Stimulation (tDCS)
Massed-Prolonged Exposure (PE)
Sham Transcranial Direct Current Stimulation (tDCS)
Conditions
Locations
Charleston VA Healthcare System
Charleston, South Carolina 29401-5799
United States
The University of Texas Health Science Center at Houston
Houston, Texas 77030
United States