A Study to Assess Adverse Events and Change in Disease Activity in Participants 12 Years of Age or Older With Locally Advanced or Metastatic Solid Tumors That Harbor MET Amplification Receiving Intravenously Infused Telisotuzumab Adizutecan
Start Date
12/1/2025
Completion Date
12/1/2030
Summary
Cancer is a condition where cells in a specific part of body grow and reproduce uncontrollably. The purpose of this study is to assess adverse events and change in disease activity of telisotuzumab adizutecan. Telisotuzumab adizutecan is an investigational drug being developed for the treatment of locally advanced or metastatic solid tumors that harbor MET amplification. This study will have 1 arm where participants will receive telisotuzumab adizutecan. Approximately 100 participants 12 years of age or older. with solid tumors harboring MET amplification will be enrolled in the study in up to 50 sites around the world. Participants will receive intravenous (IV) telisotuzumab adizutecan, as part of the 61.5 month study duration. There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at an approved institution (hospital or clinic). The effect of the treatment will be frequently checked by medical assessments, blood tests, questionnaires and side effects.
Eligibility Criteria
Age Range: 12 years to No maximum
Interventions
Telisotuzumab Adizutecan
Conditions
Locations
Beverly Hills Cancer Center /ID# 275465
Beverly Hills, California 90211
United States
City of Hope National Medical Center /ID# 275613
Duarte, California 91010
United States
Valkyrie Clinical Trials /ID# 275547
Los Angeles, California 90067
United States
Yale University School of Medicine /ID# 275978
New Haven, Connecticut 06510
United States
Florida Cancer Specialists - North /ID# 277137
St. Petersburg, Florida 33705
United States
Northwestern University Feinberg School of Medicine /ID# 276436
Chicago, Illinois 60611-2927
United States
University of Chicago Medical Center /ID# 275342
Chicago, Illinois 60637
United States
START Midwest /ID# 276603
Grand Rapids, Michigan 49546
United States
Memorial Sloan Kettering Cancer Center - New York - York Avenue /ID# 275999
New York, New York 10065
United States
Duke Cancer Institute /ID# 275604
Durham, North Carolina 27710
United States
SCRI Oncology Partners /ID# 275686
Nashville, Tennessee 37203
United States
Dell Seton Medical Center /ID# 276474
Austin, Texas 78701
United States
University of Texas - Southwestern Medical Center /ID# 276053
Dallas, Texas 75235
United States
The University of Texas MD Anderson Cancer Center /ID# 275663
Houston, Texas 77030
United States
South Texas Accelerated Research Therapeutics /ID# 276608
San Antonio, Texas 78229
United States
Start Mountain Region /ID# 276607
West Valley City, Utah 84119
United States
Virginia Cancer Specialists - Fairfax /ID# 276010
Fairfax, Virginia 22031
United States
Rabin Medical Center. /ID# 274341
Petah Tikva, Central District 4941492
Israel
The Chaim Sheba Medical Center /ID# 274342
Ramat Gan, Tel Aviv 5265601
Israel
Tel Aviv Sourasky Medical Center /ID# 274344
Tel Aviv, Tel Aviv 6423906
Israel
Hadassah Medical Center-Hebrew University /ID# 274343
Jerusalem, 91120
Israel
Nagoya University Hospital /ID# 276336
Nagoya, Aichi-ken 466-8560
Japan
National Cancer Center Hospital East /ID# 276298
Kashiwa-shi, Chiba 277-8577
Japan
Kyushu University Hospital /ID# 276302
Fukuoka, Fukuoka 812-8582
Japan
Hokkaido University Hospital /ID# 276333
Sapporo, Hokkaido 060-8648
Japan
Kyoto University Hospital /ID# 276398
Kyoto, Kyoto 606-8507
Japan
Tohoku University Hospital /ID# 276344
Sendai, Miyagi 980-8574
Japan
Okayama University Hospital /ID# 276299
Okayama, Okayama-ken 700-8558
Japan
National Cancer Center Hospital /ID# 276297
Chuo-Ku, Tokyo 104-0045
Japan
Seoul National University Hospital /ID# 275703
Seoul, Seoul Teugbyeolsi 03080
South Korea
Yonsei University Health System Severance Hospital /ID# 276184
Seoul, Seoul Teugbyeolsi 03722
South Korea
Samsung Medical Center /ID# 275705
Seoul, Seoul Teugbyeolsi 06351
South Korea
Clinica Universidad de Navarra - Pamplona /ID# 275503
Pamplona, Navarre 31008
Spain
Hospital Universitario Vall de Hebron /ID# 275499
Barcelona, 08035
Spain
Hospital General Universitario Gregorio Maranon /ID# 275498
Madrid, 28007
Spain
Hospital Universitario 12 de Octubre /ID# 275496
Madrid, 28041
Spain
Hospital Clinico Universitario de Valencia /ID# 275501
Valencia, 46010
Spain