A Study of Orforglipron in Female Participants With Stress Urinary Incontinence Who Have Obesity or Overweight
Start Date
9/30/2025
Completion Date
3/1/2028
Summary
The GZPS master protocol will support two independent studies, J2A-MC-GZS1 and J2A-MC-GZS2. Each study will see how well and safely orforglipron works in adult female participants with stress urinary incontinence (SUI) who have obesity or overweight. SUI is leaking urine during movement or activity such as coughing or exercising. Participation in the study will last about 58 weeks from screening to safety follow-up.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Orforglipron
Placebo
Conditions
Locations
University of Alabama -The Kirklin Clinic
Birmingham, Alabama 35233
United States
AMR Clinical
Mobile, Alabama 36608
United States
Urologic Surgeons of Arizona
Mesa, Arizona 85206
United States
Matrix Clinical Research
Los Angeles, California 90057
United States
Alarcon Urology Center
Montebello, California 90640
United States
Prestige Medical Group
Tustin, California 92780
United States
Colorado Clinical Research
Lakewood, Colorado 80228
United States
AMR Clinical
Fort Myers, Florida 33912
United States
Altus Research
Lake Worth, Florida 33461
United States
New Age Medical Research Corporation
Miami, Florida 33186
United States
Emerald Coast OBGYN Clinical Research
Panama City, Florida 32405
United States
Teak Research Consults
Lawrenceville, Georgia 30043
United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division
Troy, Michigan 48098
United States
OB/GYN Associates of Erie
Erie, Pennsylvania 16507
United States
Clinical Research of Philadelphia
Philadelphia, Pennsylvania 19114
United States
Next Level Urgent Care
Houston, Texas 77057
United States
Innovative Medical Research of Texas
Houston, Texas 77065
United States
Health Research of Hampton Roads, Inc.
Newport News, Virginia 23606
United States
Urology of Virginia
Virginia Beach, Virginia 23462
United States
Northwest Clinical Research Center
Bellevue, Washington 98007
United States
Seattle Clinical Research Center
Seattle, Washington 98104
United States
OCT Research ULC
Kelowna, V1Y 1Z9
Canada
Kelowna Health and Memory Centre
Kelowna, V1Y 5A8
Canada
Alpha Recherche Clinique - Lévis
Lévis, G6V 0C9
Canada
The Fe/Male Health Centre
Oakville, L6H 3P1
Canada
Alpha Recherche Clinique
Québec, G2J 0C4
Canada
ALPHA Recherche Clinique
Québec, G3K 2P8
Canada
CaRe Clinic
Red Deer, T4P 1K4
Canada
Sunnybrook Research Institute
Toronto, M4N 3M5
Canada
Peking University People's Hospital
Beijing, 100034
China
Xuanwu Hospital Capital Medical University
Beijing, 100053
China
Peking University Third Hospital
Beijing, 100091
China
Peking University First Hospital
Beijing, 102600
China
Sichuan Provincial People's Hospital
Chengdu, 610072
China
Chengdu Women and Children Center Hospital
Chengdu, 610091
China
2nd Affiliated Hospital Chongqing Medical University
Chongqing, 400010
China
Zhujiang Hospital
Guangzhou, 510280
China
The First Affiliated Hospital of Jinan University
Guangzhou, 510630
China
Zhejiang Provincial People's Hospital
Hangzhou, 310014
China
Second Affiliated hospital of Anhui Medical University
Hefei, 230000
China
Gansu Provincial Hospital
Lanzhou, 730000
China
Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School
Nanjing, 210000
China
Ningbo First Hospital
Ningbo, 315010
China
Obstetrics & Gynecology Hospital of Fudan University
Shanghai, 200011; 200090
China
Peking University Shenzhen Hospital
Shenzhen, 518036
China
The Second Affiliated Hospital of Soochow University
Suzhou, 215004
China
Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology
Wuhan, 430030
China
The First Affiliated Hospital of Xi'an Jiaotong University
Xi'an, 710061
China
The First Affiliated hospital of Xiamen University
Xiamen, 361003
China
General Hospital of Ningxia Medical University
Yinchuan, 750004
China
Afimed - Urologicka ambulance
Benešov, 256 01
Czechia
Gynekologie Šottner
Brno, 603 00
Czechia
Centrum Panevniho Dna
Karlovy Vary, 360 17
Czechia
Kestr-gyn
Náchod, 547 01
Czechia
G-CENTRUM Olomouc
Olomouc, 772 00
Czechia
NEUMED gynekologická ambulance
Olomouc, 779 00
Czechia
GYNORD plus
Ostrava, 709 00
Czechia
Gyncare
Pilsen, 301 00
Czechia
Nestátní zdravotnické zařízení GONA
Prague, 110 00
Czechia
Devasya Superspeciality Kidney & Multispeciality Hospitals
Ahmedabad, 380013
India
Apollo Hospitals Ahmedabad
Ahmedabad, 382428
India
KLES Dr. Prabhakar Kore Hospital & M.R.C
Belagavi, 590010
India
Belagavi Institute of Medical Sciences - Belagavi
Belgavi, 590019
India
All India Institute of Medical Sciences
Bhubaneswar, 751019
India
Postgraduate Institute of Medical Education & Research
Chandigarh, 160012
India
Apollo Hospitals - Chennai
Chennai, 600006
India
Malla Reddy Narayana Multispeciality Hospital
Hyderabad, 500055
India
Ketki Nursing Home & Urology Hospital
Nagpur, 440012
India
Sir Ganga Ram Hospital
New Delhi, 110060
India
Lifepoint Multispeciality Hospital
Pune, 411057
India
All India Institute of Medical Sciences
Raipur, 492099
India
All India Institute of Medical Sciences - Rishikesh
Rishikesh, 249203
India
Surat Institute of Digestive Sciences Hospitals
Surat, 395002
India
Banaras Hindu University
Varanasi, 221005
India
Hasegawa Hospital - Arakawa
Arakawa City, 116-0014
Japan
Takasu Nephrology and Urology Clinic
Chiba, 261-0004
Japan
Yotsuya Medical Cube
Chiyoda City, 102-0084
Japan
St. Luke's International Hospital
Chūōku, 104-8560
Japan
Mito Medical Center
Higashiibaraki, 311-3117
Japan
Nihon University Itabashi Hospital
Itabashiku, 173-8610
Japan
Kokura Memorial Hospital
Kitakyushu, 802-8555
Japan
Touyu Clinic
Matsudo, 270-0034
Japan
Tokyo Saiseikai Central Hospital
Minatoku, 108-0073
Japan
Koujunkai Daido Clinic
Nagoya, 457-8511
Japan
Women's Clinic LUNA NEXT STAGE
Naka-ku, Yokohama-Shi, 231-0861
Japan
Chiba Saiseikai Narashino hospital
Narashino, 275-8580
Japan
Nakazawa Nephrology and Urology Clinic
Nonoichi, 921-8824
Japan
Miyabi Urogyne Clinic
Okayama, 700-0822
Japan
Nakatsu Hospital
Osaka, 530-0012
Japan
Yukigaya Urology Clinic
Ōta-ku, 145-0065
Japan
Kashiwazaki Obstetrics and Gynecology Clinic
Saitama-shi, 330-0855
Japan
Izumi Chuo Hospital
Sendai, 981-3121
Japan
Toride Urology Clinic
Toride, 302-0021
Japan
Tsukuba Urocare Clinic
Tsukuba, 305-0821
Japan
Medical Center Metas
Chihuahua City, 31110
Mexico
Scientia Investigacion Clinica S.C.
Chihuahua City, 31207
Mexico
Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C.
Ciudad Madero, 89440
Mexico
Health Pharma Querétaro
Juriquilla, 76230
Mexico
RM Pharma Specialists - Unidad Especializada en Datos
Mexico City, 03100
Mexico
Centro de Oncología de Precisión - Mexico City
Mexico City, 03330
Mexico
Quemex Medical and Research
Mexico City, 14308
Mexico
Medical Care and Research SA de CV
Mérida, 97070
Mexico
Clinstile, S.A. de C.V.
México, 06700
Mexico
Jose Gerardo Garza Leal
Monterrey, 64060
Mexico
Centro de investigación y control metabólico
Monterrey, 66465
Mexico
Centro de Investigacion Clinica Chapultepec
Morelia, 58260
Mexico
Medimanage Research
Tlalpan, 14050
Mexico
IN VIVO
Bydgoszcz, 85-048
Poland
AIDPORT Sp. z o.o.
Skórzewo, 60-185
Poland
Centrum Medyczne Euromedis
Szczecin, 70-111
Poland
Medical Concierge Centrum Medyczne
Warsaw, 02-798
Poland
Centrum Medyczne Ginemedica
Wroclaw, 50-414
Poland
EMC Instytut Medyczny SA
Wroclaw, 54-239
Poland
Centrul Medical Unirea
Brasov, 500091
Romania
Spitalul Clinic Judetean de Urgenta (Brasov)
Brasov, 500152
Romania
Spitalul Clinic de Nefrologie Doctor Carol Davila
Bucharest, 010731
Romania
Spitalul Universitar de Urgenta Militar Central Dr. Carol Davila
Bucharest, 010825
Romania
Delta Health Care
Bucharest, 014142
Romania
Spitalul Clinic Colentina
Bucharest, 020125
Romania
Spitalul de Urgenta al Ministerului Administratiei si Internelor "Prof. Dr. Dimitrie Gerota"
Bucharest, 021373
Romania
Spitalul Clinic Județean de Urgență Ilfov
Bucharest, 022105
Romania
Fundeni Clinical Institute
Bucharest, 022328
Romania
Gnosis Evomed S.R.L.
Bucharest, 030913
Romania
Spitalul Clinic Profesor Doctor Theodor Burghele
Bucharest, 050659
Romania
Spitalul Clinic Județean de Urgență
Craiova, 200642
Romania
Spitalul Clinic Judetean De Urgenta Bihor
Oradea, 410169
Romania
Clinica Polisano
Sibiu, 550253
Romania
Polaris Medical SA
Suceagu, 407062
Romania
S.C. Materna Care S.R.L.
Timișoara, 300645
Romania
Spitalul Clinic Judeţean de Urgenţă Pius Brînzeu Timişoara
Timișoara, 300723
Romania
Hallym University Sacred Heart Hospital
Anyang-si, 14068
South Korea
The Catholic University of Korea, Bucheon St. Mary's Hospital
Bucheon-si, 14647
South Korea
Pusan National University Hospital
Busan, 49241
South Korea
Chonnam National University Hospital
Gwangju, 61469
South Korea
Kyungpook National University Hospital
Junggu, 41944
South Korea
Severance Hospital, Yonsei University Health System
Seoul, 03722
South Korea
Samsung Medical Center
Seoul, 06351
South Korea