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NCT07204275PHASE2, PHASE3Recruiting

Evaluation of Efficacy, Safety, and Tolerability of Povetacicept in Participants With Primary Membranous Nephropathy (pMN)

Vertex Pharmaceuticals Incorporated

Start Date

9/30/2025

Completion Date

12/29/2028

Summary

The purpose of this study is to evaluate the efficacy, safety, and tolerability of povetacicept in participants with primary membranous nephropathy (pMN).

Eligibility Criteria

Age Range: 18 years to 75 years

Key Inclusion Criteria: • Diagnosed with pMN with confirmatory historical biopsy. If no historical biopsy was performed that confirmed pMN, a biopsy can be performed during Screening to confirm eligibility Key Exclusion Criteria: • Hypersensitivity to investigational medicinal product or to any of its excipients Other protocol defined Inclusion/Exclusion criteria will apply

Interventions

DRUG

Povetacicept

DRUG

Tacrolimus

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Conditions

Primary Membranous Nephropathy

Locations

Renal Associates

Montgomery, Alabama 36117

United States

Southwest Kidney Institute, PLC (SKI) - Surprise

Surprise, Arizona 85374

United States

Academic Medical Research Institute (AMRI)

Los Angeles, California 90022

United States

Valiance Clinical Research - Internal Medicine

Tarzana, California 91356

United States

Western Nephrology & Metabolic Bone Disease PC

Arvada, Colorado 80002

United States

Bioresearch Partner

Miami, Florida 33127

United States

CTR Oakwater, LLC

Orlando, Florida 32806

United States

Clinical Site Partners, LLC - Orlando

Winter Park, Florida 32789

United States

DaVita Clinical Research Columbus

Columbus, Georgia 31904

United States

Georgia Nephrology

Lawrenceville, Georgia 30046

United States

CARE Institute-Boise Kidney

Boise, Idaho 83706

United States

NANI Research

Hinsdale, Illinois 60521

United States

DaVita Clinical Research Edina

Edina, Minnesota 55435

United States

Kidney Specialists of Southern Nevada

Las Vegas, Nevada 89107

United States

Carolina Nephrology Greenville

Greenville, South Carolina 29605

United States

Carolina Nephrology, PA

Spartanburg, South Carolina 29306

United States

El Paso Kidney Specialists

El Paso, Texas 79902

United States

Provecta Research Network

Houston, Texas 77027

United States

DaVita Clinical Research Houston

Houston, Texas 77054

United States

Davita Clinical Research San Antonio

San Antonio, Texas 78251

United States

Utah Kidney Research

Salt Lake City, Utah 84115

United States

Milwaukee Neprologists, SC

Wauwatosa, Wisconsin 53226

United States

Monash Medical Centre

Clayton,

Australia

Concord Repatriation General Hospital

Concord,

Australia

St George Private Hospital

Kogarah,

Australia

University of Newcastle - John Hunter Hospital (JHH)

New Lambton Heights,

Australia

Freire Pesquisa Clinica

Belo Horizonte,

Brazil

Santa Casa de Misericordia

Porto Alegre,

Brazil

Universidade Federal de Pernmabuco

Recife,

Brazil

Fundação Bahiana de Infectologia

Salvador,

Brazil

Hospital das Clinicas da Faculdade de Medicina da USP - HC- FMUSP

São Paulo,

Brazil

The First Affiliated Hospital of Baotou Medical College

Baotou,

China

Beijing Tsinghua Changgung Hospital

Beijing,

China

Peking University First Hospital

Beijing,

China

The First Affiliated Hospital of Bengbu Medical University

Bengbu,

China

The Second Norman Bethune Hospital of Jilin University

Changchun,

China

Xiangya Hospital of Central South University

Changsha,

China

Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital

Chengdu,

China

Dalian Municipal Central Hospital

Dalian,

China

Dongguan People's Hospital

Dongguan,

China

Fuyang People's Hospital

Fuyang,

China

Guangdong Provincial People's Hospital

Guangzhou,

China

The First Affiliated Hospital,Sun Yat-sen University

Guangzhou,

China

The 2nd Affiliated Hospital of Harbin Medical University

Harbin,

China

The Affiliated Huai'an No.1 People's Hospital of Nanjing Medical University

Huai'an,

China

The Second Qilu Hospital of Shandong University

Jinan,

China

Liu Zhou Works Hospital

Liuzhou,

China

The First Affiliated Hospital of Nanchang University

Nanchang,

China

The People's Hospital of Guangxi Zhuang Autonomous Region

Nanning,

China

Nanyang Central Hospital

Nanyang,

China

The First Affiliated Hospital of Ningbo University

Ningbo,

China

Renji Hospital Shanghai Jiaotong University School of Medicine

Shanghai,

China

Shanghai General Hospital

Shanghai,

China

The First Hospital of Hebei Medical University

Shijiazhuang,

China

The Fourth Hospital of Hebei Medical University

Shijiazhuang,

China

The Fourth Hospital of Hebei Medical Univesrsity

Shijiazhuang,

China

The Second Hospital of Hebei Medical University

Shijiazhuang,

China

Tai'an City Central Hosptial

Tai’an,

China

Weifang People's Hospital

Weifang,

China

Wuxi People's Hospital

Wuxi,

China

The First Affiliated Hospital of Xi 'an Jiaotong University

Xi'an,

China

The First Affiliated Hospital of Xiamen University

Xiamen,

China

Yantai YuHuangDing Hospital

Yantai,

China

Yichang Central People Hospital

Yichang,

China

Vseobecna fakultni nemocnice v Praze - Klinika nefrologie

Prague,

Czechia

Charite - Universitaetsmedizin Berlin Campus Benjamin Frankl

Allemagne,

Germany

Klinikum St. Georg gGmbH - Nephrology

Leipzig,

Germany

Universitaetsklinikum Leipzig - Medizinische Klinik und Poliklinik III - Klinik und Poliklinik fuer Endokrinologie, Nephrologie

Leipzig,

Germany

Universitaetsklinikum Wuerzburg - Innere Medizin, Nephrologie

Würzburg,

Germany

Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont

Szeged,

Hungary

Beaumont Hospital

Dublin,

Ireland

St. Vincent'S University Hospital

Dublin,

Ireland

University Hospital Galway

Galway,

Ireland

AOU Consorziale Policlinico di Bari - Nefrologia, Dialisi e Trapianti

Bari,

Italy

IRCCS Ospedale Policlinico San Martino

Genova,

Italy

Azienda Ospedaliera Universitaria Federico II

Naples,

Italy

Fondazione IRCCS Policlinico San Matteo

Pavia,

Italy

Fondazione Salvatore Maugeri - Nefrologia e Dialisi

Pavia,

Italy

Kanazawa University Hospital

Kanazawa,

Japan

Kasugai Municipal Hospital

Kasugai,

Japan

Okayama University Hospital

Okayama,

Japan

Nagoya University Hospital

Shōwaku,

Japan

The University of Osaka Hospital

Suita,

Japan

Fujita Health University

Toyoake-Shi,

Japan

Juntendo University Urayasu Hospital

Urayasu,

Japan

Hallym University Sacred Heart Hospital

Anyang-si,

South Korea

Korea University Anam Hospital - Nephrology

Seoul,

South Korea

Kyung Hee University Hospital at Gangdong - Nephrology

Seoul,

South Korea

Samsung Medical Center - Nephrology

Seoul,

South Korea

Severance Hospital, Yonsei University Health System - Nephrology

Seoul,

South Korea

Yongin Severance Hospital - Nephrology

Yongin-si,

South Korea

Hospital Universitari Vall D Hebron

Barcelona,

Spain

Hospital Universitario Reina Sofia

Córdoba,

Spain

Hospital Ribera Polusa

Lugo,

Spain

Clinica Universidad de Navarra - Nefrología

Pamplona,

Spain

Hospital Universitario Virgen de la Macarena - Nefrología

Seville,

Spain

University Hospital of Derby and Burton NHS Foundation Trust - Royal Derby Hospital

Derby,

United Kingdom

Doncaster and Bassetlaw Hospitals NHS Foundation Trust - Doncaster Royal Infirmary

Doncaster,

United Kingdom

NHS Lothian - Royal Infirmary of Edinburgh

Edinburgh,

United Kingdom

Imperial College Healthcare NHS Trust - Hammersmith Hospital

London,

United Kingdom

St George's University Hospitals NHS Foundation Trust - St George's Hospital- Renal Medicine

London,

United Kingdom

The Royal Wolverhampton NHS Trust - New Cross Hospital

Wolverhampton,

United Kingdom