A Clinical Study of Calderasib (MK-1084) in People With Advanced Solid Tumors (MK-1084-014)
Start Date
12/4/2025
Completion Date
4/9/2032
Summary
Researchers want to learn if calderasib given alone or with cetuximab can treat certain advanced solid tumors in people with the KRAS G12C mutation. The goals of this study are to learn: * How many people have the cancer respond (get smaller or go away) to calderasib alone or with cetuximab and how these responses compare * About the safety of calderasib alone or with cetuximab and if people tolerate the treatments.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Calderasib
Cetuximab
Conditions
Locations
Greater Baltimore Medical Center ( Site 1104)
Baltimore, Maryland 21204
United States
START Midwest ( Site 1103)
Grand Rapids, Michigan 49546
United States
Comprehensive Cancer Centers of Nevada ( Site 1109)
Las Vegas, Nevada 89169
United States
Rutgers Cancer Institute of New Jersey ( Site 1100)
New Brunswick, New Jersey 08903
United States
START Mountain Region ( Site 1106)
West Valley City, Utah 84119
United States
Virginia Cancer Specialists ( Site 1102)
Fairfax, Virginia 22031
United States
Prince of Wales Hospital-Medical Oncology ( Site 1003)
Randwick, New South Wales 2031
Australia
Westmead Hospital ( Site 1000)
Westmead, New South Wales 2145
Australia
Epworth Freemasons ( Site 1004)
Melbourne, Victoria 3002
Australia
Jewish General Hospital-CRU ( Site 2900)
Montreal, Quebec H3T 1E2
Canada
FALP ( Site 1200)
Santiago, Region M. de Santiago 7500921
Chile
Centro de Oncología de Precisión ( Site 1202)
Santiago, Region M. de Santiago 7560908
Chile
Clinica San Carlos de Apoquindo ( Site 1203)
Santiago, Region M. de Santiago 7620002
Chile
Bradfordhill ( Site 1201)
Santiago, Region M. de Santiago 8420383
Chile
Beijing Cancer hospital ( Site 1318)
Beijing, Beijing Municipality 100142
China
The First Affiliated Hospital of Xiamen University ( Site 1304)
Xiamen, Fujian 361003
China
Sun Yat-sen University Cancer Center ( Site 1303)
Guangzhou, Guangdong 510060
China
The first affiliated hospital, Sun Yat-Sen university ( Site 1329)
Guangzhou, Guangdong 510080
China
Harbin Medical University Cancer Hospital ( Site 1308)
Harbin, Heilongjiang 150000
China
Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 1326)
Wuhan, Hubei 430000
China
Jiangsu Province Hospital ( Site 1324)
Nanjing, Jiangsu 210029
China
The First Affiliated Hospital of Nanchang University ( Site 1307)
Nanchang, Jiangxi 330209
China
Jinan Central Hospital ( Site 1313)
Jinan, Shandong 250013
China
Shanghai Chest Hospital ( Site 1300)
Shanghai, Shanghai Municipality 200030
China
Fudan University Shanghai Cancer Center ( Site 1325)
Shanghai, Shanghai Municipality 200032
China
Zhongshan Hospital,Fudan University ( Site 1301)
Shanghai, Shanghai Municipality 200032
China
Zhejiang Cancer Hospital ( Site 1311)
Hangzhou, Zhejiang 310022
China
Taizhou Hospital of Zhejiang Province ( Site 1312)
Linhai, Zhejiang 317000
China
Rigshospitalet ( Site 1403)
Copenhagen, Capital Region 2100
Denmark
Odense Universitetshospital ( Site 1401)
Odense, Region Syddanmark 5000
Denmark
Universitätsklinikum Leipzig ( Site 1602)
Leipzig, Saxony 04103
Germany
Universitätsklinikum Jena ( Site 1603)
Jena, Thuringia 07747
Germany
General Hospital of Athens "Laiko" ( Site 1701)
Athens, Attica 11527
Greece
European Interbalkan Medical Center-Oncology Department ( Site 1700)
Thessaloniki, 57001
Greece
Emek Medical Center ( Site 1800)
Afula, 1834111
Israel
Hadassah Medical Center ( Site 1801)
Jerusalem, 9112001
Israel
Sourasky Medical Center ( Site 1802)
Tel Aviv, 6423906
Israel
Istituto Clinico Humanitas-U.O di Oncologia medica ed Ematologia ( Site 1902)
Rozzano, Milano 20089
Italy
Fondazione IRCCS Istituto Nazionale dei Tumori-Struttura Complessa Oncologia Medica 1 ( Site 1900)
Milan, 20133
Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Medical Oncology ( Site 1901)
Roma, 00168
Italy
Kanagawa Cancer Center ( Site 2002)
Yokohama, Kanagawa 241-8515
Japan
National Cancer Center Hospital ( Site 2000)
Chūō, Tokyo 104-0045
Japan
Cancer Institute Hospital of JFCR ( Site 2003)
Koto, Tokyo 135-8550
Japan
Haukeland universitetssykehus ( Site 2102)
Bergen, Hordaland 5021
Norway
Oslo universitetssykehus, Radiumhospitalet ( Site 2101)
Oslo, 0379
Norway
MTZ Clinical Research powered by Pratia ( Site 2205)
Warsaw, Masovian Voivodeship 02-172
Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 2200)
Warsaw, Masovian Voivodeship 02-781
Poland
Szpital Wojewodzki im. Mikolaja Kopernika w Koszalinie ( Site 2203)
Koszalin, West Pomeranian Voivodeship 75-581
Poland
Seoul National University Hospital ( Site 2301)
Seoul, 03080
South Korea
Asan Medical Center ( Site 2302)
Seoul, 05505
South Korea
Samsung Medical Center ( Site 2300)
Seoul, 06351
South Korea
Hospital Virgen de la Victoria ( Site 2403)
Málaga, Malaga 29010
Spain
Hospital Universitari Vall d Hebron ( Site 2401)
Barcelona, 08035
Spain
Hospital Clinic de Barcelona ( Site 2402)
Barcelona, 08036
Spain
Hospital Clinico San Carlos ( Site 2404)
Madrid, 28040
Spain
Karolinska Universitetssjukhuset Solna ( Site 2501)
Stockholm, Stockholm County 171 64
Sweden
Sahlgrenska Universitetssjukhuset. ( Site 2502)
Gothenburg, Västra Götaland County 413 45
Sweden
Adana Medical Park Seyhan Hastanesi ( Site 2706)
Adana, 01140
Turkey (Türkiye)
Gazi Universitesi Tip Fakultesi Hastanesi ( Site 2702)
Ankara, 06560
Turkey (Türkiye)
Ankara Bilkent Şehir Hastanesi ( Site 2701)
Ankara, 06800
Turkey (Türkiye)
Hacettepe Universitesi-oncology hospital ( Site 2700)
Ankara, 6230
Turkey (Türkiye)
Koc University Hospital ( Site 2704)
Istanbul, 34010
Turkey (Türkiye)
Royal Free Hospital ( Site 2801)
London, Camden NW3 2QG
United Kingdom
The Christie NHS Foundation Trust ( Site 2803)
Manchester, M20 4BX
United Kingdom