NCT07210437NARecruiting
Longitudinal Autonomic Characterization as a Predictor for Secondary Medical Complications Post-SCI
Mayo Clinic
Start Date
1/31/2026
Completion Date
6/1/2028
Summary
The purpose of this research is to learn about how the body is able to balance changes in blood pressure, how that changes over time, and how these changes impact a participant's risk of developing medical problems.
Eligibility Criteria
Age Range: 18 years to 75 years
Inclusion criteria
* 18-75 years old
* Spinal cord injury with neurological level of injury from C6-T12
* ASIA Impairment Scale A-D.
* Either acute SCI \<3 months prior (n=10) or chronic SCI (\>1 year since injury, n=8).
Exclusion criteria
* Symptoms of cardiovascular (including, but not limited to: hypertension, stroke, chest pain, etc.), respiratory, peripheral neurological or autonomic disease (particularly diabetes mellitus requiring treatment);
* Women who are pregnant or lactating
* Taking or being administered a medication known to potentially have adverse interactions with phenylephrine
* In the judgement of the principal investigator, any illness or condition that will interfere with the patient's ability to comply with the protocol, compromise patient safety, or interfere with the interpretation of the study results.
Interventions
DIAGNOSTIC_TEST
Tests of sympathetic inhibition
DIAGNOSTIC_TEST
Tests of above level sympathetic activation
DIAGNOSTIC_TEST
Testing of below level sympathetic activation
Conditions
Spinal Cord Injuries
Locations
Mayo Clinic
Rochester, Minnesota 55905
United States