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NCT07216521Recruiting

Intent of Surgery for IPMN

NYU Langone Health

Start Date

9/15/2025

Completion Date

12/1/2025

Summary

This multicenter retrospective observational cohort study seeks to: 1. Classify surgical intent in patients with resected Intraductal Papillary Mucinous Neoplasms (IPMN) and quantify the proportion of IPMN-associated cancers diagnosed as overt pancreatic cancer with incidental IPMN association on pathology. 2. Compare clinicopathologic features and outcomes between surveillance-detected and incidentally detected IPMN-derived pancreatic cancers. 3. Revise and redefine risk features limited to patients undergoing surgery for IPMN-related indications, identifying optimal predictors of malignant IPMN (high-grade dysplasia or invasive cancer).

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * All patients (18 years old of greater) who underwent surgical resection for IPMN (including low-, high-grade dysplasia, or invasive carcinoma) between July 1, 2015 and July 1, 2025. Exclusion Criteria: * Patients with concomitant pancreatic ductal adenocarcinoma (PDAC)

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Conditions

Intraductal Papillary Mucinous Neoplasm

Locations

Mayo Clinic

Phoenix, Arizona 85054

United States

Johns Hopkins University

Baltimore, Maryland 21287

United States

Massachusetts General Hospital

Boston, Massachusetts 02114

United States

Mayo Clinic

Rochester, Minnesota 55905

United States

NYU Langone Health

New York, New York 10016

United States

Memorial Sloan Kettering

New York, New York 10022

United States

Duke University

Durham, North Carolina 27710

United States

MD Anderson Cancer Center

Houston, Texas 77030

United States

Nanjing University

Nanjing, 210093

China

Heidelberg University

Heidelberg, 69117

Germany

San Raffaele Hospital

Milan, 20132

Italy

Padua University

Padua, 1222

Italy

University of Amsterdam

Amsterdam, 1105

Netherlands

University of Utrecht

Utrecht, 3584

Netherlands