Back to Trials
NCT07218302PHASE2Recruiting

Eating Disorder Chatbot Optimization

Washington University School of Medicine

Start Date

7/17/2026

Completion Date

7/31/2029

Summary

The purpose of this study is to optimize an automated digital chatbot intervention for adults with clinical or subclinical eating disorders.

Detailed Description

Eating disorders (EDs) are common-affecting an estimated 10% of individuals in their lifetimes-and have disabling consequences being associated with high psychiatric comorbidity, impairment, and mortality. Despite this, less than 20% of individuals with an ED ever receive treatment. When individuals do seek treatment, many are not evidence-based and come with high costs and burden on the healthcare system. One solution to this is a chatbot intervention that is evidence-based, affordable, and accessible for people with EDs. This project will assess four candidate components of a cognitive behavioral therapy (CBT)-based chatbot to determine the optimal chatbot package. CBT is the recommended first-line treatment for EDs, yet there is no research to date on which components are most effective or needed for meaningful change in ED psychopathology. In this study the intervention will be divided into four components targeting: (1) over-evaluation of weight and shape; (2) dietary restraint; (3) emotion dysregulation; and (4) resisting urges to binge. The investigators will recruit 800 adults with a binge/purge-type ED who are not currently in treatment and randomly assign participants to one of 16 experimental conditions (each combination from 1 to all 4 components) or the waitlist-control group. Participants will be assessed on changes in ED psychopathology, ED behavior frequencies, comorbid symptoms (i.e., depression, anxiety), and clinical impairment at 1-, 2-, and 6-months following randomization. An optimized package of these candidate components that is most effective, while remaining efficient, will be identified using multiphase optimization strategy (MOST). The investigators' established relationships with industry and non-profit partners will ensure this optimized package has high potential for scalability and dissemination into the community.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * 18+ years old * Owns a smartphone * Speaks English * US resident * Screens for a clinical or subclinical eating disorder * Low suicidality * Not currently in treatment for an eating disorder * Does not have a medical condition or take medications that impact appetite/weight * Not currently pregnant Exclusion Criteria: * Below 18 years of age * Does not own a smartphone * Does not speak English * Lives outside the US * Screens as: at risk for an eating disorder, anorexia nervosa, atypical anorexia nervosa, avoidant/restrictive food intake disorder, or not at risk for an ED * High suicidality * In treatment for an eating disorder * Has a medical condition or takes medication(s) that impact appetite/weight * Currently pregnant

Interventions

BEHAVIORAL

Digital Chatbot Program

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Eating Disorders

Locations

Washington University in St. Louis

St Louis, Missouri 63105

United States