A Study of Baricitinib (LY3009104) for the Delay of Stage 3 Type 1 Diabetes in At-Risk Children and Adults
Start Date
1/12/2026
Completion Date
7/1/2031
Summary
The purpose of this study is to find out if baricitinib can delay the onset of clinical type 1 diabetes (T1D) in people who are at high risk to develop T1D. Participation in the study will last up to approximately 5 years.
Eligibility Criteria
Age Range: 1 years to 35 years
Interventions
Baricitinib
Placebo
Conditions
Locations
Tallahassee Memorial HealthCare
Tallahassee, Florida 32308
United States
University of South Florida
Tampa, Florida 33612
United States
University of Iowa
Iowa City, Iowa 52242
United States
Iowa Diabetes and Endocrinology Research Center
West Des Moines, Iowa 50266
United States
Novak Center for Children's Health
Louisville, Kentucky 40202
United States
Children's Hospital of Philadelphia (CHOP)
Philadelphia, Pennsylvania 19104
United States
University of Virginia
Charlottesville, Virginia 22903
United States
Women's and Children's Hospital
Adelaide, 5006
Australia
Box Hill Hospital
Box Hill, 3128
Australia
Royal Brisbane and Women's Hospital
Brisbane, 4029
Australia
Centre for Children's Health Research
Brisbane, 4101
Australia
Royal Children's Hospital
Melbourne, 3052
Australia
The Royal Melbourne Hospital
Parkville, 3050
Australia
Perth Children's Hospital
Perth, 6009
Australia
Sydney Children's Hospital
Randwick, 2031
Australia
The Children's Hospital at Westmead
Westmead, 2145
Australia
UZ Brussel
Brussels, 1090
Belgium
Cliniques universitaires Saint-Luc
Brussels, 1200
Belgium
Antwerp University Hospital
Edegem, 2650
Belgium
UZ Leuven
Leuven, 3000
Belgium
CHU UCL Namur/Site Sainte Elisabeth
Namur, 5000
Belgium
Freire Pesquisa Clínica
Belo Horizonte, 30150-320
Brazil
Centro de Diabetes Curitiba
Curitiba, 80810-040
Brazil
Hospital Universitario Walter Cantidio
Fortaleza, 60430-270
Brazil
Cendi - Endocrinologia e Diabetes
Goiânia, 74230-035
Brazil
Centro de Pesquisa Clínica de Marília - CPCLIM
Marília, 17504-072
Brazil
Universidade Federal do Rio de Janeiro
Rio de Janeiro, 21941-590
Brazil
Instituto de Pesquisa Clinica
São Paulo, 01223-001
Brazil
CPCLIN
São Paulo, 01228-200
Brazil
IBTED - Tecnologia e Educação em Diabetes
São Paulo, 04038-032
Brazil
Hospital das Clinicas FMUSP
São Paulo, 05403-000
Brazil
Alberta Diabetes Institute
Edmonton, T6G 2E1
Canada
BC Diabetes Office
Vancouver, V5Y 3W2
Canada
Oulun yliopistollinen sairaala
Oulu, 90220
Finland
Tampereen yliopistollinen sairaala
Tampere, 33520
Finland
Turku University Hospital
Turku, 20520
Finland
Hospices Civils de Lyon - Hopital Louis Pradel
Bron, 69677
France
Centre Hospitalier Sud Francilien
Corbeil-Essonnes, 91106
France
Hopital Claude Huriez - CHU de Lille
Lille, 59037
France
Assistance Publique Hôpitaux de Marseille - Hôpital de la Timone
Marseille, 13385
France
Pitie Salpetriere University Hospital
Paris, 75013
France
Hopitaux Universitaires Paris Centre-Hopital Cochin
Paris, 75014
France
Hôpital Universitaire Necker Enfants Malades
Paris, 75015
France
Assistance Publique - Hopitaux de Paris (AP-HP) - Hopital Robert Debre - Centre Hospitalo Universitaire (C -T
Paris, 75019
France
CHU Rangueil
Toulouse, 31059
France
Klinik Josefinum
Augsburg, 86154
Germany
Universitaetsklinikum Augsburg
Augsburg, 86156
Germany
Universitaetsklinikum Carl Gustav Carus, Technischen Universitaet Dresden
Dresden, 01307
Germany
Hannoversche Kinderheilanstalt
Hanover, 30173
Germany
TUM Klinikum
München, 80939
Germany
Yitzhak Shamir Medical Center
Beer Yaacov, 70300
Israel
Soroka Medical Center
Beersheba, 8410101
Israel
Rambam Health Care Campus
Haifa, 3109601
Israel
Carmel Hospital
Haifa, 3436212
Israel
Institute of Diabetes, Technology and Research - Clalit Health
Herzliya, 4600201
Israel
Hadassah Medical Center
Jerusalem, 9112001
Israel
Meir Medical Center
Kfar Saba, 4428164
Israel
Schneider Children's Medical Center
Petah Tikva, 4920235
Israel
Rabin Medical Center
Petah Tikva, 4941492
Israel
Sheba Medical Center
Ramat Gan, 5262100
Israel
Sheba Medical Center
Ramat Gan, 5262100
Israel
Kaplan Medical Center
Rehovot, 7610001
Israel
Sourasky Medical Center
Tel Aviv, 6423906
Israel
Ospedale Pediatrico Salesi
Ancona, 60123
Italy
IRCCS - AOU di Bologna
Bologna, 40138
Italy
Ospedale Microcitemico
Cagliari, 09121
Italy
Azienda Ospedaliera Universitaria Meyer IRCCS
Florence, 50139
Italy
Ospedale San Raffaele
Milan, 20132
Italy
University of Naples Federico II
Naples, 80100
Italy
University of Naples Federico II
Naples, 80131
Italy
Azienda Ospedaliero Universitaria Maggiore della Carità
Novara, 28100
Italy
Azienda Ospedale - Università Padova
Padova, 35128
Italy
Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento
Verona, 37126
Italy
Abeno Medical Clinic
Abeno, 545-0052
Japan
Saitama Medical University Hospital
Iruma, 350-0495
Japan
Nippon Medical School Musashi Kosugi Hospital
Kawasaki, 211-8533
Japan
Yamanashi Prefectural Central Hospital
Kofu, 400-8506
Japan
Seino Internal Medicine Clinic
Kōriyama, 963-8851
Japan
Jinnouchi Hospital
Kumamoto, 862-0976
Japan
Nagano Municipal Hospital
Nagano, 381-8551
Japan
Nakakinen clinic
Naka, 311-0113
Japan
Niigata University Medical & Dental Hospital
Niigata, 951-8520
Japan
Diabeter - Rotterdam
Rotterdam, 3011 TA
Netherlands
Haukeland Universitetssjukehus
Bergen, 5021
Norway
Akershus Universitetssykehus
Lørenskog, 1478
Norway
Oslo Universitetssykehus Ullevål
Oslo, 0450
Norway
Oslo Universitetssykehus Aker
Oslo, 0586
Norway
Stavanger Universitetssykehus
Stavanger, 4011
Norway
MTZ Clinical Research Powered by Pratia
Warsaw, 02-172
Poland
Medical Network Spółka z o.o. WIP Warsaw IBD Point Profesor Kierkuś
Warsaw, 04-501
Poland
2Ca Braga
Braga, 4710-243
Portugal
Unidade Local de Saude de Matosinhos
Matosinhos Municipality, 4464-513
Portugal
Centro Materno Infantil do Norte
Porto, 4050
Portugal
ULSAM - Hospital de Santa Luzia
Viana do Castelo, 4900-858
Portugal
Unidade Local De Saude De Gaia/Espinho E.P.E.
Vila Nova de Gaia, 4434-502
Portugal
OSI Ezkerraldea-Enkarterri-Cruces - Hospital Universitario Cruces
Barakaldo, 48903
Spain
Hospital Sant Joan de Déu
Esplugues de Llobregat, 08950
Spain
Hospital Universitario Ramón y Cajal
Madrid, 28034
Spain
Skånes Universitetssjukhus Malmö
Malmö, 21428
Sweden
Universitetssjukhuset Örebro
Örebro, 701 85
Sweden
Queen Elizabeth Hospital Birmingham
Birmingham, B15 2TH
United Kingdom
Birmingham Children's Hospital
Birmingham, B4 6NH
United Kingdom
Addenbrooke's Hospital
Cambridge, CB2 2QQ
United Kingdom
Noah's Ark Children's Hospital for Wales
Cardiff, CF14 4XW
United Kingdom
University Hospital of Wales
Cardiff, CF14 4XW
United Kingdom
Queen Elizabeth University Hospital
Glasgow, G51 4TF
United Kingdom
Royal London Hospital
London, E1 1BB
United Kingdom
St. George's Hospital
London, SW17 0QT
United Kingdom
The John Radcliffe Hospital
Oxford, OX3 9DU
United Kingdom
Southampton General Hospital
Southampton, SO16 6YD
United Kingdom