NCT07803744PHASE1Recruiting
A Study of Tirzepatide (LY3298176) in Participants With Type 1 Diabetes Mellitus and Overweight or Obesity
Eli Lilly and Company
Start Date
9/11/2026
Completion Date
12/1/2026
Summary
The main purpose of this study is to learn more how tirzepatide affects stomach emptying in participants with Type 1 Diabetes Mellitus (T1DM) and overweight or obesity. Participation in this study will last about 8 weeks, including screening and follow-up.
Eligibility Criteria
Age Range: 18 years to 70 years
Inclusion Criteria:
* Have a diagnosis of type 1 diabetes mellitus (T1DM) and have been treated with insulin for at least 1 year prior to screening
* Have a body mass index (BMI) greater than or equal to 25.0 kilograms per square meter (kg/m2) at screening
* Are of stable weight, that is a self-reported change of 5 kg or less, for at least 90 days prior to screening
Exclusion Criteria:
* Participants who have a known clinically significant gastric emptying abnormality
* Have undergone weight loss surgery such as gastric bypass (bariatric) surgery or restrictive bariatric surgery
* Have known allergies or intolerance to acetaminophen, tirzepatide, or glucagon-like peptide-1 (GLP-1) receptor agonists
Interventions
DRUG
Tirzepatide
DRUG
Acetaminophen
DRUG
Placebo
Conditions
Diabetes Mellitus, Type 1OverweightObesity
Locations
Clinical Pharmacology of Miami
Miami, Florida 33172
United States