A Study to Compare Linvoseltamab Monotherapy and Linvoseltamab + Carfilzomib Combination Therapy With Standard-of-Care Combination Regimens in Adult Participants With Relapsed/Refractory Multiple Myeloma (RRMM)
Start Date
1/2/2026
Completion Date
8/23/2034
Summary
This study is researching a drug called linvoseltamab (also called "study drug") either given alone or in combination with another anti-myeloma drug called carfilzomib, compared to several standard treatments for progressive Multiple Myeloma (MM) after at least 1 but no more than 3 prior therapies. The aim of this study is to see if the safety and efficacy of linvoseltamab alone or in combination with carfilzomib can deliver better outcomes (deeper and longer responses that help extend life) than standard treatment options. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the drug less effective or could lead to side effects)
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Linvoseltamab
Carfilzomib
Daratumumab
Dexamethasone
Pomalidomide
Bortezomib
Conditions
Locations
Emory Winship Cancer Institute
Atlanta, Georgia 30322
United States
Memorial Sloan Kettering Cancer Center
New York, New York 10021
United States
OhioHealth
Columbus, Ohio 43214
United States
University of Texas Health Science Center, Houston
Houston, Texas 77030
United States
Mater Misericordiae Ltd
Brisbane, Queensland 4101
Australia
Gold Coast Hospital and Health Service
Southport, Queensland 4215
Australia
Alfred Hospital
Melbourne, Victoria 3004
Australia
Chonnam National University Hwasun Hospital
Hwasun, Jeollanam-do 58128
South Korea
Seoul National University Hospital
Seoul, 03080
South Korea
Severance Hospital; Division of Hematology
Seoul, 03722
South Korea
Asan Medical Center
Seoul, 05505
South Korea
Samsung Medical Center
Seoul, 06351
South Korea
Seoul St. Mary's Hospital, The Catholic University of Korea
Seoul, 06591
South Korea
Ulsan University Hospital
Ulsan, 44033
South Korea
Aberdeen Royal Infirmary
Aberdeen, Aberdeenshire AB25 2ZN
United Kingdom
Royal Cornwall Hospital National Health Service (NHS) Foundation Trust
Truro, Cornwall TR1 3LJ
United Kingdom
University Hospitals Plymouth National Health Service (NHS) Foundation Trust - Hematology
Plymouth, Devon PL6 8DH
United Kingdom
Norfolk and Norwich University Hospital National Health Service (NHS) Foundation Trust
Norwich, Norfolk NR4 7UY
United Kingdom
University Hospitals Birmingham NHS Trust, Center for Clinical
Birmingham, West Midlands B15 2GW
United Kingdom
Ninewells Hospital and Medical School
Dundee, DD1 9SY
United Kingdom