Back to Trials
NCT07223125PHASE1Recruiting

A Study of JNJ-89862175 for Treatment of Advanced Solid Tumors

Janssen Research & Development, LLC

Start Date

10/10/2025

Completion Date

8/15/2028

Summary

The purpose of this study is to determine safe and effective dose (recommended phase 2 doses \[RP2Ds\]) of JNJ-89862175 in Part 1 (dose escalation), and to further evaluate how safe JNJ-89862175 is at the RP2Ds in Part 2 (dose expansion) in participants with advanced stage solid tumors.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Participants must have histologically or cytologically confirmed, metastatic or unresectable solid tumor of lung adenocarcinoma, renal cell carcinoma (RCC): clear cell or papillary carcinoma, endometrioid ovarian cancer and endometrioid uterine carcinoma * Have an eastern cooperative oncology group (ECOG) performance status of 0 to 1 at screening * Participants on study drug and for 4 months after the last dose of study drug must not breastfeed or be pregnant, not donate gametes (that is, eggs or sperms) or freeze for future use for the purposes of assisted reproduction and wear an external condom Exclusion Criteria: * Active central nervous system (CNS) involvement unless clinically stable * History of clinically significant cardiovascular disease within 6 months prior to signing informed consent * History of solid organ or hematologic stem cell transplantation * Known allergies, hypersensitivity, or intolerance to excipients of JNJ-89862175 * Has prior or concurrent second malignancy (other than the disease under study) in which the natural history or treatment is likely to interfere with safety endpoints or efficacy of the study drug

Interventions

DRUG

JNJ-89862175

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Advanced-stage Solid Tumors

Locations

AdventHealth Orlando

Orlando, Florida 32803

United States

NEXT Oncology

Irving, Texas 75039

United States

Centre Leon Berard

Lyon, 69373

France

Gustave Roussy

Villejuif, 94805

France

Severance Hospital Yonsei University Health System

Seoul, 03722

South Korea

Samsung Medical Center

Seoul, 06351

South Korea