NCT07226804Recruiting
Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules
M.D. Anderson Cancer Center
Start Date
11/14/2025
Completion Date
8/31/2030
Summary
To observe the outcomes of nsPFA therapy to treat benign thyroid nodules.
Detailed Description
Primary Objectives • To evaluate the thyroid nodule volume changes over time in participants undergoing nsPFA as part of routine clinical care Secondary Objectives * To determine changes in health-related quality of life changes following ultrasound-guided nsPFA * To evaluate the ultrasound features of thyroid nodules over time following ultrasound-guided nsPFA. * To assess the incidence and nature of complications following ultrasound-guided nsPFA, categorized into Minor and Major complications.
Eligibility Criteria
Age Range: 18 years to No maximum
Eligibility Criteria
* Scheduled to undergo ultrasound guided nsPFA as standard of care
* Age 18 to 80 years.
* Capable of providing independent consent.
* Presence of biopsy-confirmed benign thyroid nodule , defined as one of the following:
* Benign FNA X 2 or
* Benign US guided FNA X 1 + benign thyroid nodule ultrasound appearance (TI-RADS 2) or
* Benign FNA X 1 and radiographic/laboratory evidence of functional nature
* Nodule measuring \>2cm in greatest dimension
* Presence of compressive symptoms reasonably attributable to thyroid nodule (i.e. pressure sensation, dysphagia, dysphonia, respiratory distress)
* No abnormal cervical lymph nodes during screening visit .
Exclusion Criteria
* Age \<18
* Patients considered unsuitable for nsPFA by the treating physician
Interventions
OTHER
Questionnaire
Conditions
Thyroid NodulesPulsed Field Ablation
Locations
MD Anderson Cancer Center
Houston, Texas 77030
United States