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NCT07226804Recruiting

Nanosecond Pulsed Field Ablation in the Management of Benign Thyroid Nodules

M.D. Anderson Cancer Center

Start Date

11/14/2025

Completion Date

8/31/2030

Summary

To observe the outcomes of nsPFA therapy to treat benign thyroid nodules.

Detailed Description

Primary Objectives • To evaluate the thyroid nodule volume changes over time in participants undergoing nsPFA as part of routine clinical care Secondary Objectives * To determine changes in health-related quality of life changes following ultrasound-guided nsPFA * To evaluate the ultrasound features of thyroid nodules over time following ultrasound-guided nsPFA. * To assess the incidence and nature of complications following ultrasound-guided nsPFA, categorized into Minor and Major complications.

Eligibility Criteria

Age Range: 18 years to No maximum

Eligibility Criteria * Scheduled to undergo ultrasound guided nsPFA as standard of care * Age 18 to 80 years. * Capable of providing independent consent. * Presence of biopsy-confirmed benign thyroid nodule , defined as one of the following: * Benign FNA X 2 or * Benign US guided FNA X 1 + benign thyroid nodule ultrasound appearance (TI-RADS 2) or * Benign FNA X 1 and radiographic/laboratory evidence of functional nature * Nodule measuring \>2cm in greatest dimension * Presence of compressive symptoms reasonably attributable to thyroid nodule (i.e. pressure sensation, dysphagia, dysphonia, respiratory distress) * No abnormal cervical lymph nodes during screening visit . Exclusion Criteria * Age \<18 * Patients considered unsuitable for nsPFA by the treating physician

Interventions

OTHER

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Conditions

Thyroid NodulesPulsed Field Ablation

Locations

MD Anderson Cancer Center

Houston, Texas 77030

United States