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NCT07226843PHASE1Recruiting

A Study of LY4584180 in Adult Participants With Previously Treated Blood Cancers

Eli Lilly and Company

Start Date

4/17/2026

Completion Date

2/1/2030

Summary

The main purpose of this study is to evaluate safety and efficacy, and measure how much LY4584180 gets into the bloodstream and how long it takes the body to eliminate it in patients with previously treated blood cancers. For each participant, the study could last about 9 months or possibly longer including screening.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Has been treated for the following blood cancers and has received at least 2 prior lines of systemic therapy or not eligible for available therapy: * Diffuse large B-cell lymphoma - not otherwise specified * High-grade B-cell lymphoma * Diffuse large B-cell lymphoma - transformed from indolent lymphomas * Follicular large B-cell lymphoma * Follicular lymphoma * Other non-Hodgkin lymphoma * Has measurable disease * Has discontinued all previous treatments for cancer and has recovered from the immediate effects of therapy Exclusion Criteria: * Has an active second cancer * Has known central nervous system (CNS) involvement by systemic lymphoma. Patients with previous treatment for CNS involvement who are neurologically stable and without evidence of active CNS disease may be eligible and enrolled if a compelling clinical rationale is provided by the Investigator and with documented Sponsor approval. * Has known Cytomegalovirus infection. Participants with negative status are eligible * Has known hepatitis B or C infection or uncontrolled HIV * Has known significant heart disease

Interventions

DRUG

LY4584180

DRUG

Rituximab

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

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Conditions

Lymphoma, Non-Hodgkin'sLymphoma, Diffuse Large B-CellFollicular Lymphoma

Locations

Mayo Clinic - Scottsdale

Scottsdale, Arizona 85259

United States

City of Hope

Duarte, California 91010

United States

University of California, Los Angeles (UCLA) - Medical Center

Los Angeles, California 90059

United States

University of California, San Francisco (UCSF) - Helen Diller Family Comprehensive Cancer Center

San Francisco, California 94158

United States

Colorado Blood Cancer Institute

Denver, Colorado 80218

United States

University of Miami - Sylvester Cancer Center

Miami, Florida 33136

United States

Florida Cancer Specialists - Sarasota

Sarasota, Florida 34236

United States

Emory University Hospital

Atlanta, Georgia 30322

United States

Massachusetts General Hospital

Boston, Massachusetts 02114

United States

Dana-Farber Cancer Institute

Boston, Massachusetts 02215

United States

Mayo Clinic - Rochester

Rochester, Minnesota 55905

United States

Columbia University

New York, New York 10032

United States

University of Rochester

Rochester, New York 14618

United States

The Ohio State University (OSU)

Columbus, Ohio 43210

United States

Oregon Health & Science University (OHSU)

Portland, Oregon 97239

United States

Sarah Cannon Research Institute

Nashville, Tennessee 37203

United States

Vanderbilt University Medical Center

Nashville, Tennessee 37212

United States

Texas Oncology - DFW (Sammons CC)

Dallas, Texas 75246

United States

Baylor College of Medicine

Houston, Texas 77030

United States

University of Washington - Fred Hutchinson Cancer Center (Seattle Cancer Care Alliance)

Seattle, Washington 98195

United States

Froedtert Hospital and the Medical College of Wisconsin

Milwaukee, Wisconsin 53226

United States

CHU de Nantes - Hotel-Dieu

Nantes, 44093

France

Institut Curie

Paris, 75005

France

CHU Bordeaux - Hopital Haut-Leveque - Centre Francois Magendie

Pessac, 33604

France

HCL Centre Hospitalier Lyon Sud

Pierre-Bénite, 69495

France

Oncopole Claudius Regaud

Toulouse, 31059

France

Charite Universitaetsmedizin Berlin

Berlin, 10117

Germany

Universitaetsklinikum Koeln (AoeR)

Cologne, 50937

Germany

Universitaetsklinikum Essen

Essen, 45147

Germany

Universitaetsklinikum Frankfurt - Klinikum der Johann Wolfgang Goethe Universitaet

Frankfurt am Main, 60590

Germany

IRCCS Azienda Ospedaliero-Universitaria di Bologna - Policlinico di Sant Orsola

Bologna, 40138

Italy

Istituto Europeo di Oncologia

Milan, 20141

Italy

National Cancer Center Hospital East

Chiba, 277-8577

Japan

Okayama University Hospital

Okayama, 700-8558,

Japan

Cancer Institute Hospital of JFCR

Tokyo, 135-8550

Japan

Pratia Onkologia Katowice

Katowice, 40-519

Poland

Pratia MCM Krakow

Krakow, 30-727

Poland

AIDPORT Sp. z o.o.

Skorzewo, 60-185

Poland

Instytut Hematologii i Transfuzjologii w Warszawie

Warsaw, 02-776

Poland

Institut Catala d'Oncologia - L'Hospitalet

Barcelona, 08908

Spain

South Texas Accelerated Research Therapeutics (START) Madrid - Hospital Fundacion Jimenez Diaz

Madrid, 28040

Spain

King's College Hospital

London, SE5 9RS

United Kingdom

The Royal Marsden NHS Foundation Trust

London, SW3 6JJ

United Kingdom

Nottingham City Hospital

Nottingham, NG5 1PB

United Kingdom

Derriford Hospital

Plymouth, PL6 8DH

United Kingdom

University Hospital Southampton NHS Foundation Trust

Southampton, SO16 6YD

United Kingdom