Study to Assess the Effects of Angiopoietin-like Protein 3 (ANGPTL3) Inhibition in Adult Participants With Diabetic Kidney Disease
Start Date
1/9/2026
Completion Date
4/7/2028
Summary
This study is researching experimental drugs called ALN-ANG3 and evinacumab (called "study drugs"). The study is focused on participants who have diabetic kidney disease. The aim of the study is to see how safe and effective the study drugs are. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times
Eligibility Criteria
Age Range: 18 years to 80 years
Interventions
ALN-ANG3
Evinacumab
ALN-ANG3 placebo
Evinacumab placebo
Conditions
Locations
Apogee Clinical Research, LLC
Huntsville, Alabama 35801
United States
Applied Research Center of Arkansas
Little Rock, Arkansas 72205
United States
AME Clinical Research
Huntington Beach, California 92647
United States
Amicis Research Center
Northridge, California 91325
United States
FOMAT - Vista del Mar Medical Group
Oxnard, California 93036
United States
Central Coast Nephrology
Salinas, California 93901
United States
North America Research Institute
San Dimas, California 91773
United States
Amicis Research Center
Santa Clarita, California 91355
United States
Valiance Clinical Research
Tarzana, California 91356
United States
Amicis Research Center
Valencia, California 91355
United States
National Institute of Clinical Research, Inc.
Victorville, California 92392
United States
Yale University
New Haven, Connecticut 06510
United States
D&H Doral Research Center
Doral, Florida 33122
United States
AGA Clinical Trials
Hialeah, Florida 33012
United States
Convenient Medical Center
Hialeah, Florida 33013
United States
Elixia Hollywood
Hollywood, Florida 33024
United States
D&H Pompano Research Center
Margate, Florida 33063
United States
LCC Medical Research Institute
Miami, Florida 33126
United States
D&H National Research Centers, Inc
Miami, Florida 33155
United States
Regenerate Primary Medical Research, LLC
Miami, Florida 33155
United States
Ocean Blue Medical Research Center - Internal Medicine
Miami Springs, Florida 33166
United States
Innovia Research Center
Miramar, Florida 33027
United States
Central Florida Kidney Specialists Oakwater
Orlando, Florida 32806
United States
Bolanos Clinical Research
Pembroke Pines, Florida 33026
United States
Progressive Medical Research
Port Orange, Florida 32127
United States
CDC Research Institute
Port Saint Lucie, Florida 34952
United States
D&H Tamarac Research Center
Tamarac, Florida 33321
United States
Metabolic Research Institute
West Palm Beach, Florida 33401
United States
Privia Medical Group of Georgia, LLC
Savannah, Georgia 31406
United States
Research by Design, LLC - Internal Medicine
Chicago, Illinois 60643
United States
IMA Clinical Research
Monroe, Louisiana 71201
United States
Elixia Michigan Kidney Consultants
Pontiac, Michigan 48341
United States
Elixia MNA
City of Saint Peters, Missouri 63376
United States
Clinical Research Consultants, LLC
Kansas City, Missouri 64111
United States
University of Nebraska Medical Center
Omaha, Nebraska 68198
United States
DaVita Clinical Research
Las Vegas, Nevada 89107
United States
Velocity Clinical Research
Binghamton, New York 13905
United States
CHEAR Center LLC
The Bronx, New York 10455
United States
Eastern Nephrology Associates - Greenville West
Greenville, North Carolina 27834
United States
Eastern Nephrology Associates - New Bern
New Bern, North Carolina 28562
United States
Brookview Hills Research Associates, LLC
Winston-Salem, North Carolina 27103
United States
Northeast Clinical Research Center
Bethlehem, Pennsylvania 18017
United States
Suburban Research Associates
West Chester, Pennsylvania 19380
United States
Southeast Renal Research Institute
Chattanooga, Tennessee 37404
United States
Arlington Nephrology, PLLC.
Arlington, Texas 76015
United States
M3 Wake Research Dallas - Internal Medicine
Dallas, Texas 75224
United States
Revival Research Institute, LLC
Dallas, Texas 75231
United States
Epic Medical Research LLC
DeSoto, Texas 75115
United States
El Paso Kidney Specialists-Davita Clinical Research
El Paso, Texas 79902
United States
Juno Research, LLC
Houston, Texas 77040
United States
Prolato Research LLC
Houston, Texas 77054
United States
Clinical Trial Network, LLC
Houston, Texas 77074
United States
Gulf Coast Clinical Research
Katy, Texas 77450
United States
R & H Clinical Research, Inc.
Katy, Texas 77450
United States
Sunbeam Clinical Research
McKinney, Texas 75069
United States
Clinical Advancement Center
San Antonio, Texas 78212
United States
University of Texas Health - San Antonio
San Antonio, Texas 78229
United States