A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors
Start Date
12/23/2025
Completion Date
4/14/2030
Summary
The purpose of this study is to learn about the safety and effects of the study medicine when given alone or together with other anti-cancer therapies. Anti-cancer therapy is a type of treatment to stop the growth of cancer. This study also aims to find the best amount of study medication. This study is seeking participants that have advanced or metastatic breast cancer (BC), or advanced or metastatic colorectal cancer (CRC). All participants in this study will take the study medication (PF-08032562) as pill by mouth. This will be repeated for 28-day cycles. Depending on which part of the study participants are enrolled into, they will receive the study medication PF-08032562 alone or in combination with other anti-cancer medications. The study medication (PF-08032562) will be taken by mouth (PO) in combination with other anti-cancer medications given in the study clinic by intramuscular (IM) injection into the muscle or intravenous (IV) infusion that is directly injected into the veins at different times (depending on the treatment) during the 28-day cycle. The study may also test different schedules.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
PF-08032562
Fulvestrant
Cetuximab
Fluorouracil
Oxaliplatin
Leucovorin
Bevacizumab
Conditions
Locations
City of Hope (City of Hope National Medical Center, City of Hope Medical Center)
Duarte, California 91010
United States
START Midwest, LLC
Grand Rapids, Michigan 49546
United States
Memorial Sloan Kettering Cancer Center - Investigational Drug Service Pharmacy
Long Island City, New York 11101
United States
Memorial Sloan Kettering Cancer Center - David H. Koch Center for Cancer Care (74th Street).
New York, New York 10021
United States
Memorial Sloan Kettering Cancer Center 53rd street.
New York, New York 10022
United States
Memorial Sloan Kettering Cancer Center - Main Campus
New York, New York 10065
United States
The University of Texas MD Anderson Cancer Center - Conroe
Conroe, Texas 77384
United States
The University of Texas - M.D. Anderson Cancer Center
Houston, Texas 77030
United States
The University of Texas, MD Anderson Cancer Center - West Houston
Houston, Texas 77079
United States
The University of Texas, MD Anderson Cancer Center - League City
League City, Texas 77573
United States
START San Antonio
San Antonio, Texas 78229
United States
The University of Texas, MD Anderson Cancer Center - Sugar Land
Sugar Land, Texas 77478
United States
START Mountain Region
West Valley City, Utah 84119
United States