A Study of CX11 Tablets in Patients With Type 2 Diabetes Mellitus
Start Date
2/6/2026
Completion Date
1/7/2027
Summary
This study is testing whether a new medication called CX11 works and is safe for participants with type 2 diabetes who have not reached good blood sugar control while taking a steady dose of metformin, with or without a steady dose of an SGLT2 inhibitor, for at least 90 days. The study is being done at multiple medical centers. Participants are assigned by chance (randomized) to different groups, and neither the participants nor the study staff know which group they're in (double-blind). The groups are compared side by side (parallel), and some participants will receive inactive pills (placebo) to help measure the true effect of the study drug. After screening, participants will be randomly placed into one of six groups, with equal chances of being in any group. Each group will receive a different dose of CX11 or a placebo. Treatment will last 24 weeks. After that, all participants will have a 2-week follow-up period to check on safety.
Eligibility Criteria
Age Range: 18 years to 75 years
Interventions
CX11
Placebo
Conditions
Locations
Central Research Associates - Flourish - PPDS
Birmingham, Alabama 35205-1605
United States
AES - DRS - Synexus Clinical Research US, Inc. - Birmingham
Birmingham, Alabama 35211-1320
United States
AES - DRS - Optimal Research Alabama - Huntsville
Huntsville, Alabama 35802-2569
United States
Ark Clinical Research - Long Beach
Long Beach, California 90815-2521
United States
Flourish Research - Walnut Creek - PPDS
Walnut Creek, California 94598-3343
United States
AES - DRS - Optimal Research Florida - Melbourne
Melbourne, Florida 32934-8172
United States
Tampa General Hospital
Tampa, Florida 33606-3571
United States
Conquest Research LLC - Winter Park
Winter Park, Florida 32789-1857
United States
Privia Medical Group Georgia, LLC - Albany - Javara - PPDS
Albany, Georgia 31707-0205
United States
Javara Inc. - Fayetteville
Fayetteville, Georgia 30214
United States
Privia Medical Group Georgia, LLC - Savannah - Javara - PPDS
Savannah, Georgia 31406-3928
United States
Privia Medical Group Georgia, LLC - Thomasville - Javara - PPDS
Thomasville, Georgia 31792-6618
United States
AES - DRS - Synexus Clinical Research US, Inc. - Chicago
Chicago, Illinois 60602-3960
United States
AES - DRS - Synexus Clinical Research US, Inc. - Evansville
Evansville, Indiana 47714-7513
United States
Privia Medical Group, LLC - Kelly's Collaborative Care - Javara - PPDS
Silver Spring, Maryland 20901-1586
United States
Elixia Health - Springfield - Elixia - PPDS
Springfield, Massachusetts 01103
United States
Elixia Health - Michigan Kidney Consultants, LLC - Elixia - PPDS
Pontiac, Michigan 48341
United States
AES - DRS - Synexus Clinical Research US, Inc. - Edina - Minneapolis
Edina, Minnesota 55435-4305
United States
Mankato Clinic - East Main Street - Javara - PPDS
Mankato, Minnesota 56001
United States
Hassman Research Institute - Berlin - CenExel - PPDS
Berlin, New Jersey 08009
United States
Albuquerque Clinical Trials Inc
Albuquerque, New Mexico 87102-2619
United States
M3 Wake Research, Inc - M3 WR
Raleigh, North Carolina 27612-8106
United States
Unity Clinical Research
Oklahoma City, Oklahoma 73118-2872
United States
Monroe Biomedical Research Charleston
North Charleston, South Carolina 29406
United States
M3 Wake Research - Dallas
Dallas, Texas 75246
United States
University of Texas Southwestern Medical Center
Dallas, Texas 75390-7202
United States
SMS Clinical Research, LLC - 400 W. Kearney St
Mesquite, Texas 751497
United States
AES - DRS - Synexus Clinical Research US, Inc. - San Antonio
San Antonio, Texas 78229-3272
United States
Flourish Research - San Antonio - PPDS
San Antonio, Texas 78229-3539
United States
Privia Medical Group- North Texas - Stephenville - Javara - PPDS
Stephenville, Texas 76401-1860
United States
Conquest Research - Arlington
Vienna, Virginia 22182
United States
AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Poznaniu
Poznan, Greater Poland Voivodeship 60-702
Poland
Centrum Medyczne Pratia Bydgoszcz - PPDS
Bydgoszcz, Kuyavian-Pomeranian Voivodeship 85 001
Poland
Medyczne Centrum Diabetologiczno-Endokrynologiczno-Metaboliczne
Krakow, Lesser Poland Voivodeship 31-261
Poland
FutureMeds - Krakow - PPDS
Krakow, Lesser Poland Voivodeship 31-501
Poland
METABOLICA Sp. z o.o
Tarnów, Lesser Poland Voivodeship 33-100
Poland
AES - DRS - Synexus Polska Sp. z o.o. Oddzial we Wroclawiu
Wroclaw, Lower Silesian Voivodeship 50-381
Poland
AES - DRS - Synexus Polska Sp. Z o.o. Oddzial w Lodzi
Lodz, Lódzkie 90-127
Poland
FutureMeds - Lodz - PPDS
Lodz, Lódzkie 91-363
Poland
FutureMeds - Warszawa Centrum - PPDS
Warsaw, Masovian Voivodeship 00-215
Poland
AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Warszawie
Warsaw, Masovian Voivodeship 02-672
Poland
ETG Warszawa - PPDS
Warsaw, Masovian Voivodeship 02-677
Poland
AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Gdansku
Gdansk, Pomeranian Voivodeship 80-382
Poland
AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Gdyni
Gdynia, Pomeranian Voivodeship 81-537
Poland
AES - DRS - Synexus Polska Sp. z o.o. Oddzial w Czestochowie
Częstochowa, Silesian Voivodeship 42-202
Poland