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NCT07392190PHASE3Recruiting

A Study of Eloralintide (LY3841136) in Participants With Persistent Obesity Who Are Treated With a Weekly Incretin

Eli Lilly and Company

Start Date

2/10/2026

Completion Date

7/1/2028

Summary

The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with placebo in participants with persistent obesity or overweight, with or without type 2 diabetes, and on stable incretin background therapy. Participation in the study will last about 80 weeks.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Are on stable incretin therapy at screening * With persistent obesity or overweight defined as: * ≥30 kg/m2 OR * ≥27 kg/m2 with at least one existing obesity related complication at screening: * hypertension * dyslipidemia * obstructive sleep apnea * cardiovascular disease (for example, ischemic cardiovascular disease, New York Heart Association Functional Class I-III heart failure), or * type 2 diabetes * Have a stable body weight (\<5% body weight change) at screening Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening) * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) * Have type 1 diabetes * Have taken any of the following antihyperglycemic medications within 90 days before screening: * dipeptidyl peptidase-4 (DPP-4) inhibitors * amylin analogs * insulin * Have had within 90 days prior to screening: * heart attack * stroke * coronary artery revascularization * unstable angina, or * hospitalization due to congestive heart failure * Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure

Interventions

DRUG

Eloralintide

DRUG

Placebo

Interested in This Trial?

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Conditions

OverweightObesity

Locations

Birmingham Clinical Research

Birmingham, Alabama 35209

United States

RIO Clinical Trials - Phoenix

Phoenix, Arizona 85016

United States

Headlands Research - Scottsdale

Scottsdale, Arizona 85260

United States

Novak Clinical Research - Tucson - North La Cholla Boulevard

Tucson, Arizona 85741

United States

Irvine Clinical Research

Irvine, California 92614

United States

Scripps Whittier Diabetes Institute

La Jolla, California 92037

United States

EndoTrials Center for Clinical Research

La Mesa, California 91942

United States

Peninsula Research Associates

Rolling Hills Estates, California 90274

United States

Care Access - Sacramento

Sacramento, California 95831

United States

Artemis Institute for Clinical Research

San Diego, California 92123

United States

Southern California Clinical Research

Santa Ana, California 92701

United States

University Clinical Investigators, Inc.

Tustin, California 92780

United States

New England Research Associates, LLC

Bridgeport, Connecticut 06606

United States

Yale University School of Medicine

New Haven, Connecticut 06519

United States

Chase Medical Research, LLC

Waterbury, Connecticut 06708

United States

JEM Research Institute

Atlantis, Florida 33462

United States

AMR Clinical

Doral, Florida 33172

United States

Northeast Research Institute (NERI)

Fleming Island, Florida 32003

United States

Jacksonville Center for Clinical Research

Jacksonville, Florida 32216

United States

New Horizon Research Center

Miami, Florida 33165

United States

St Johns Center for Clinical Research

Saint Augustine, Florida 32086

United States

Metabolic Research Institute, Inc.

West Palm Beach, Florida 33401

United States

Teak Research Consults - Dunwoody

Dunwoody, Georgia 30338

United States

Center for Advanced Research & Education

Gainesville, Georgia 30501

United States

Clinical Research Atlanta

Stockbridge, Georgia 30281

United States

Family First Medical Center

Idaho Falls, Idaho 83404

United States

Great Lakes Clinical Trials - Ravenswood

Chicago, Illinois 60640

United States

Iowa Diabetes and Endocrinology Research Center

West Des Moines, Iowa 50266

United States

Cotton O'Neil Diabetes & Endocrinology

Topeka, Kansas 66606

United States

AMR Clinical

Lexington, Kentucky 40509

United States

IMA Clinical Research Monroe - Armand

Monroe, Louisiana 71201

United States

Centennial Medical Group

Columbia, Maryland 21045

United States

Brigham and Women's Hospital Diabetes Program

Boston, Massachusetts 02115

United States

MedVadis Research Corporation

Waltham, Massachusetts 02451

United States

Great Lakes Research Institute

Southfield, Michigan 48075

United States

Revive Research Institute, Inc.

Southfield, Michigan 48075

United States

Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

Troy, Michigan 48098

United States

Clinical Research Professionals

Chesterfield, Missouri 63005

United States

NYU Langone Health

New York, New York 10016

United States

Weill Cornell Medical College

New York, New York 10021

United States

IMA Clinical Research Manhattan

New York, New York 10036

United States

University of North Carolina Medical Center

Chapel Hill, North Carolina 27514

United States

Medication Management

Greensboro, North Carolina 27405

United States

Carteret Medical Group

Morehead City, North Carolina 28557

United States

Accellacare - Wilmington - 1917 Tradd Court

Wilmington, North Carolina 28401

United States

CTI Clinical Research Center

Cincinnati, Ohio 45212

United States

Care Access - Lima

Lima, Ohio 45805

United States

Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18)

Pittsburgh, Pennsylvania 15236

United States

Trial Management Associates

Myrtle Beach, South Carolina 29572

United States

UT Southwestern Medical Center

Dallas, Texas 75390

United States

Juno Research

Houston, Texas 77040

United States

Activian Clinical Research

Kingwood, Texas 77339

United States

Texas Valley Clinical Research (TVCR) - Mission

Mission, Texas 78572

United States

Synergy Groups Medical LLC - Missouri City

Missouri City, Texas 77459

United States

IMA Clinical Research San Antonio

San Antonio, Texas 78229

United States

Endeavor Clinical Trials

San Antonio, Texas 78240

United States

Consano Clinical Research, LLC

Shavano Park, Texas 78231

United States

Texas Valley Clinical Research

Weslaco, Texas 78596

United States

Medrasa Clinical Research

Wylie, Texas 75098

United States

Emeritus Research

Botany, 2019

Australia

Box Hill Hospital

Box Hill, 3128

Australia

Royal Brisbane and Women's Hospital

Brisbane, 4029

Australia

Emeritus Research

Camberwell, 3124

Australia

Barwon Health

Geelong, 3220

Australia

Austin Health - Repatriation Hospital

Heidelberg West, 3081

Australia

AIM Research

Merewether, 2291

Australia

Southern Adelaide Diabetes & Endocrine Services

Oaklands Park, 5046

Australia

Royal North Shore Hospital

St Leonards, 2065

Australia

Innovate Clinical Research

Waitara, 2077

Australia

Imelda General Hospital

Bonheiden, 2820

Belgium

Université Libre de Bruxelles - Hôpital Erasme

Brussels, 1070

Belgium

Ziekenhuis Oost-Limburg, Campus St.-Jan

Genk, 3600

Belgium

Jan Yperman Ziekenhuis

Ieper, 8900

Belgium

AZ Groeninge Campus Kennedylaan

Kortrijk, 8500

Belgium

UZ Leuven

Leuven, 3000

Belgium

AZ Sint-Maarten

Mechelen, 2800

Belgium

Meclinas

Mechelen, 2800

Belgium

Az Damiaan vzw

Ostend, 8400

Belgium

Quanta Diagnóstico e Terapia

Curitiba, 80045170

Brazil

Centro de Diabetes Curitiba

Curitiba, 80810-040

Brazil

Private Practice - Dr.Miguel N. Hissa

Fortaleza, 60430-350

Brazil

CPCLIN

São Paulo, 01228-200

Brazil

Hospital 9 De Julho

São Paulo, 01409-901

Brazil

CEDOES

Vitória, 29055450

Brazil

Integral Pesquisa e Ensino

Votuporanga, 15500-269

Brazil

Luhe Hospital

Beijing, 100000

China

The First Hospital of Jilin University

Changchun, 130021

China

The Second Hospital of Jilin University

Changchun, 130041

China

The Second Xiangya Hospital of Central South University

Changsha, 410011

China

Sichuan Provincial People's Hospital

Chengdu, 610072

China

West China Hospital Sichuan University

Chengdu, 610041

China

2nd Affiliated Hospital Chongqing Medical Universi

Chongqing, 400000

China

Zhujiang Hospital

Guangzhou, 510280

China

The Affiliated Hospital of Guizhou Medical University

Guiyang, 550004

China

The Second People's Hospital of Hefei

Hefei, 230011

China

Huzhou Central Hospital

Huzhou, 313000

China

The First Affiliated Hospital of Henan University of Science &Technology

Luoyang Shi, 471023

China

Affiliated Hospital of Luzhou Medical College

Luzhou, 646000

China

Jiangxi Provincial People's Hospital

Nanchang, 330038

China

Nanjing First Hospital

Nanjing, 210006

China

Zhongda Hospital Southeast University

Nanjing, 210009

China

The Second Affiliated Hospital of Nanjing Medical University

Nanjing, 210011

China

Ningbo First Hospital

Ningbo, 315010

China

Zhongshan Hospital,Fudan University

Shanghai, 200032

China

The Central Hospital of Wuhan

Wuhan, 430014

China

Diahaza s.r.o.

Holešov, 769 01

Czechia

Milan Kvapil s.r.o., Diabetologicka ambulance

Prague, 14900

Czechia

ResTrial s.r.o.

Prague, 18100

Czechia

Emek Medical Center

Afula, 1834111

Israel

Clalit Health Services - Atlit

Atlit, 3032301

Israel

Soroka Medical Center

Beersheba, 8410101

Israel

Hillel Yaffe Medical Center

Hadera, 3810101

Israel

Rambam Health Care Campus

Haifa, 3109601

Israel

Edith Wolfson Medical Center

Holon, 5810001

Israel

Hadassah Medical Center

Jerusalem, 9112001

Israel

Meir Medical Center

Kfar Saba, 4428164

Israel

Maccabi health care services - Qiryat Motzkin

Kiryat Motzkin, 2642435

Israel

Laniado Hospital

Netanya, 4244914

Israel

Rabin Medical Center - Hasharon Campus

Petah Tikva, 4937211

Israel

Rabin Medical Center

Petah Tikva, 4941492

Israel

Sheba Medical Center

Ramat Gan, 5262100

Israel

Kaplan Medical Center

Rehovot, 7610001

Israel

Clalit Health Services - Sakhnin Community Clinic

Sakhnin, 3081000

Israel

Diabetes Medical Center

Tel Aviv, 51549

Israel

Sourasky Medical Center

Tel Aviv, 6423906

Israel

The Institute of Medical Science, Asahi Life Foundation

Chūōku, 103-0002

Japan

Rinku General Medical Center

Izumisano, 598-8577

Japan

Kanto Rosai Hospital

Kawasaki, 211-8510

Japan

Kimitsu Chuo Hospital

Kisarazu, 292-8535

Japan

Kure Medical Center

Kure, 737-0023

Japan

Takeda General Hospital - Kyoto

Kyoto, 601-1495

Japan

Mikannohana Clinic, Diabetes, Endocrinology and Metabolism

Matsuyama, 7900034

Japan

Kansai Electric Power Hospital

Osaka, 553-0003

Japan

Manda Memorial Hospital

Sapporo, 060-0062

Japan

Shimonoseki Medical Center

Shimonoseki, 750-0061

Japan

Japanese Red Cross Society - Wakayama Medical Center

Wakayama, 640-8558

Japan

Medical Center Metas

Chihuahua City, 31110

Mexico

Private Practice - Dr. Arechavaleta Granell Maria del Rosario

Guadalajara, 44670

Mexico

Invecordis S.C.

Huixquilucan, 52763

Mexico

Centro de Investigacion en Artritis y Osteoporosis SC

Mexicali, 21200

Mexico

CEINV Salud

Monterrey, 64020

Mexico

Clínica García Flores SC

Monterrey, 64610

Mexico

Advanced Clinical Research, LLC

Bayamón, 00959

Puerto Rico

Isis Clinical Research Center

Guaynabo, 00968

Puerto Rico

Mariodiab Clinic

Brasov, 500097

Romania

C.M.D.T.A. Neomed

Brasov, 500283

Romania

Geea Medical Easy Diet

Bucharest, 010627

Romania

Centrul Medical NutriLife

Bucharest, 013764

Romania

Gama Diamed

Mangalia, 905500

Romania

Diabdana

Oradea, 410147

Romania

Clinica Korall

Satu Mare, 440055

Romania

Rinart Diab SRL

Targoviste, 130168

Romania

SC Dentosim Queen SRL - Centrul Medical Diamed

Târgu Mureş, 540098

Romania

Cabinet Medical Dr.Geru

Timișoara, 300288

Romania

Hospital San Rafael - La Coruña

A Coruña, 15006

Spain

Centro Periférico de Especialidades Bola Azul

Almería, 04009

Spain

Hospital Universitari Vall d'Hebron

Barcelona, 08035

Spain

Instituto Gallego de Cirugía Ocular

Ferrol, 15402

Spain

Clínica Juaneda

Palma de Mallorca, 07014

Spain

Hospital Universitario Quironsalud Madrid

Pozuelo de Alarcón, 28223

Spain

Hospital Universitario Marqués de Valdecilla

Santander, 39008

Spain

Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)

Seville, 41003

Spain

Hospital Quiron Infanta Luisa

Seville, 41010

Spain

Vithas Hospital Sevilla

Seville, 41950

Spain

Chiayi Christian Hospital

Chiayi City, 600

Taiwan

Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, 807

Taiwan

Chang Gung Memorial Hospital at Kaohsiung

Kaohsiung Niao Sung Dist, 83301

Taiwan

China Medical University Hospital

Taichung, 404332

Taiwan

National Cheng Kung University Hospital

Tainan, 704

Taiwan

National Taiwan University Hospital

Taipei, 10002

Taiwan

Taipei Medical University Hospital

Taipei, 110

Taiwan

Taipei Veterans General Hospital

Taipei, 11217

Taiwan

Chang Gung Medical Foundation-Linkou Branch

Taoyuan, 333

Taiwan