Extension Study for Participants in Studies That Include Belzutifan (MK-6482-043/LITESPARK-043)
Start Date
3/23/2026
Completion Date
1/14/2034
Summary
Researchers are looking for new ways to treat advanced solid tumors and von Hippel-Lindau (VHL)-related tumors: * Advanced means the cancer has spread to other parts of the body (metastatic) or cannot be removed with surgery * Solid tumors are cancers mostly in body organs and tissues, not in the blood or other body liquids * VHL-related tumors are tumors caused by VHL disease. VHL disease is passed down from parents to children and people with VHL disease have a higher chance of getting certain types of cancer Researchers want to learn about the long-term effects of a trial medicine called belzutifan. Belzutifan, also called MK-6482, is designed to block a protein that helps tumors grow and survive. This is an extension trial, which means only people who were in certain other belzutifan trials (called parent trials) may be able to join. The goal of this trial is to learn how long people live after they start taking belzutifan.
Eligibility Criteria
Age Range: 18 years to No maximum
Interventions
Belzutifan
Nivolumab
Lenvatinib
Cabozantinib
Conditions
Locations
Beth Israel Deaconess Medical Center ( Site 0107)
Boston, Massachusetts 02215
United States
Dana-Farber Cancer Institute ( Site 0105)
Boston, Massachusetts 02215
United States
Karmanos Cancer Center ( Site 0108)
Detroit, Michigan 48201
United States
Hospital of the University of Pennsylvania Perelman Center for Advanced Medicine ( Site 0100)
Philadelphia, Pennsylvania 19104
United States
SCRI Oncology Partners ( Site 7000)
Nashville, Tennessee 37203
United States
START San Antonio ( Site 0104)
San Antonio, Texas 78229
United States
Fred Hutchinson Cancer Center ( Site 0106)
Seattle, Washington 98109
United States
St George Hospital-Oncology Clinical Research Unit ( Site 2701)
Kogarah, New South Wales 2217
Australia
Westmead Hospital ( Site 2703)
Sydney, New South Wales 2145
Australia
UZ Leuven ( Site 0900)
Leuven, Vlaams-Brabant 3000
Belgium
BP - A Beneficencia Portuguesa de São Paulo ( Site 0200)
São Paulo, São Paulo 01323-001
Brazil
Département clinique de médecine de laboratoire du CHUM ( Site 0001)
Montreal, Quebec H3T 1E2
Canada
James Lind Centro de Investigacion del Cancer ( Site 0304)
Temuco, Araucania 4800827
Chile
CIDO SpA ( Site 0305)
Temuco, Araucania 4810148
Chile
FALP ( Site 0300)
Santiago, Region M. de Santiago 7500921
Chile
Oncovida ( Site 0303)
Santiago, Region M. de Santiago 7500994
Chile
Bradfordhill ( Site 0301)
Santiago, Region M. de Santiago 8420383
Chile
ONCOCENTRO APYS ( Site 0302)
Viña del Mar, Valparaiso 2520598
Chile
Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 1000)
Olomouc, 77900
Czechia
Herlev and Gentofte Hospital ( Site 1200)
Herlev, Capital Region 2370
Denmark
Tampereen yliopistollinen sairaala ( Site 1305)
Tampere, Pirkanmaa 33520
Finland
Hôpitaux Universitaires de Strasbourg ( Site 1702)
Strasbourg, Bas-Rhin 67200
France
Institut Claudius Regaud ( Site 1703)
Toulouse, Haute-Garonne 31059
France
Országos Onkológiai Intézet-Urogenitális Tumorok és Klinikai Farmakológiai Osztály ( Site 1501)
Budapest, 1122
Hungary
Rambam Health Care Campus ( Site 1600)
Haifa, 3109601
Israel
Hadassah Medical Center ( Site 1604)
Jerusalem, 9112001
Israel
Rabin Medical Center ( Site 1602)
Petah Tikva, 4941492
Israel
Sheba Medical center ( Site 1601)
Ramat Gan, 5265601
Israel
Sourasky Medical Center ( Site 1603)
Tel Aviv, 64239
Israel
Kyushu University Hospital ( Site 3101)
Fukuoka, 812-8582
Japan
Maastricht Universitair Medisch Centrum - MUMC ( Site 1900)
Maastricht, Limburg 6229 HX
Netherlands
Isala, locatie Zwolle ( Site 1902)
Zwolle, Overijssel 8025 AB
Netherlands
Auckland City Hospital ( Site 3000)
Auckland, 1023
New Zealand
Zakład Diagnostyki Laboratoryjnej, Centrum Onkologii ( Site 2000)
Bydgoszcz, Kuyavian-Pomeranian Voivodeship 85-796
Poland
N.N. Blokhin NMRCO ( Site 2101)
Moscow, Moscow 115478
Russia
Russian Scientific Center of Radiology and Surgical Technologies ( Site 2100)
Saint Petersburg, Sankt-Peterburg 197758
Russia
Samsung Medical Center ( Site 2902)
Gangnam, Seoul 06351
South Korea
Severance Hospital, Yonsei University Health System ( Site 2901)
Seodaemun-gu, Seoul 03722
South Korea
Asan Medical Center ( Site 2900)
Seoul, 05505
South Korea
Hospital Universitari Vall d'Hebron ( Site 2300)
Barcelona, 08035
Spain
Hospital Universitario 12 de Octubre ( Site 2301)
Madrid, 28041
Spain
Taipei Veterans General Hospital ( Site 2800)
Taipei, 11217
Taiwan
ME І.І. Mechnykov Dnipro Regional Clinical Hospital ( Site 2601)
Dnipropetrovsk, Dnipropetrovsk Oblast 49005
Ukraine
CNCE Precarpathian Clinical Oncologic Center ( Site 2600)
Ivano-Frankivsk, Ivano-Frankivsk Oblast 76018
Ukraine
The Beatson West of Scotland Cancer Centre ( Site 2505)
Glasgow, Glasgow City G12 0YN
United Kingdom
St Bartholomew's Hospital ( Site 2500)
London, London, City of EC1A 7BE
United Kingdom
ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 2502)
London, London, City of SW3 6JJ
United Kingdom
Imperial College Healthcare NHS Trust, Charing Cross Hospital ( Site 2504)
London, London, City of W6 8RF
United Kingdom
The Christie NHS Foundation Trust ( Site 2501)
Manchester, M20 4BX
United Kingdom