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NCT07405164PHASE3Recruiting

Extension Study for Participants in Studies That Include Belzutifan (MK-6482-043/LITESPARK-043)

Merck Sharp & Dohme LLC

Start Date

3/23/2026

Completion Date

1/14/2034

Summary

Researchers are looking for new ways to treat advanced solid tumors and von Hippel-Lindau (VHL)-related tumors: * Advanced means the cancer has spread to other parts of the body (metastatic) or cannot be removed with surgery * Solid tumors are cancers mostly in body organs and tissues, not in the blood or other body liquids * VHL-related tumors are tumors caused by VHL disease. VHL disease is passed down from parents to children and people with VHL disease have a higher chance of getting certain types of cancer Researchers want to learn about the long-term effects of a trial medicine called belzutifan. Belzutifan, also called MK-6482, is designed to block a protein that helps tumors grow and survive. This is an extension trial, which means only people who were in certain other belzutifan trials (called parent trials) may be able to join. The goal of this trial is to learn how long people live after they start taking belzutifan.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: The main inclusion criteria include but are not limited to the following: * Participants with advanced solid tumors or von Hippel-Lindau-related neoplasms who are participating in belzutifan-containing studies and on active treatment in a belzutifan parent study. Exclusion Criteria: The main exclusion criteria include but are not limited to the following: * Has an on-going serious adverse event in the parent study, unless no longer hospitalized and considered clinically stable. * Is currently on a dose interruption due to an Adverse Event (AE) in the parent study; once treatment has been resumed in the parent study, the participant is eligible to enroll.

Interventions

DRUG

Belzutifan

DRUG

Nivolumab

DRUG

Lenvatinib

DRUG

Cabozantinib

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Conditions

Von Hippel-Lindau DiseaseMalignant Neoplasms

Locations

Beth Israel Deaconess Medical Center ( Site 0107)

Boston, Massachusetts 02215

United States

Dana-Farber Cancer Institute ( Site 0105)

Boston, Massachusetts 02215

United States

Karmanos Cancer Center ( Site 0108)

Detroit, Michigan 48201

United States

Hospital of the University of Pennsylvania Perelman Center for Advanced Medicine ( Site 0100)

Philadelphia, Pennsylvania 19104

United States

SCRI Oncology Partners ( Site 7000)

Nashville, Tennessee 37203

United States

START San Antonio ( Site 0104)

San Antonio, Texas 78229

United States

Fred Hutchinson Cancer Center ( Site 0106)

Seattle, Washington 98109

United States

St George Hospital-Oncology Clinical Research Unit ( Site 2701)

Kogarah, New South Wales 2217

Australia

Westmead Hospital ( Site 2703)

Sydney, New South Wales 2145

Australia

UZ Leuven ( Site 0900)

Leuven, Vlaams-Brabant 3000

Belgium

BP - A Beneficencia Portuguesa de São Paulo ( Site 0200)

São Paulo, São Paulo 01323-001

Brazil

Département clinique de médecine de laboratoire du CHUM ( Site 0001)

Montreal, Quebec H3T 1E2

Canada

James Lind Centro de Investigacion del Cancer ( Site 0304)

Temuco, Araucania 4800827

Chile

CIDO SpA ( Site 0305)

Temuco, Araucania 4810148

Chile

FALP ( Site 0300)

Santiago, Region M. de Santiago 7500921

Chile

Oncovida ( Site 0303)

Santiago, Region M. de Santiago 7500994

Chile

Bradfordhill ( Site 0301)

Santiago, Region M. de Santiago 8420383

Chile

ONCOCENTRO APYS ( Site 0302)

Viña del Mar, Valparaiso 2520598

Chile

Fakultni nemocnice Olomouc-Onkologicka klinika ( Site 1000)

Olomouc, 77900

Czechia

Herlev and Gentofte Hospital ( Site 1200)

Herlev, Capital Region 2370

Denmark

Tampereen yliopistollinen sairaala ( Site 1305)

Tampere, Pirkanmaa 33520

Finland

Hôpitaux Universitaires de Strasbourg ( Site 1702)

Strasbourg, Bas-Rhin 67200

France

Institut Claudius Regaud ( Site 1703)

Toulouse, Haute-Garonne 31059

France

Országos Onkológiai Intézet-Urogenitális Tumorok és Klinikai Farmakológiai Osztály ( Site 1501)

Budapest, 1122

Hungary

Rambam Health Care Campus ( Site 1600)

Haifa, 3109601

Israel

Hadassah Medical Center ( Site 1604)

Jerusalem, 9112001

Israel

Rabin Medical Center ( Site 1602)

Petah Tikva, 4941492

Israel

Sheba Medical center ( Site 1601)

Ramat Gan, 5265601

Israel

Sourasky Medical Center ( Site 1603)

Tel Aviv, 64239

Israel

Kyushu University Hospital ( Site 3101)

Fukuoka, 812-8582

Japan

Maastricht Universitair Medisch Centrum - MUMC ( Site 1900)

Maastricht, Limburg 6229 HX

Netherlands

Isala, locatie Zwolle ( Site 1902)

Zwolle, Overijssel 8025 AB

Netherlands

Auckland City Hospital ( Site 3000)

Auckland, 1023

New Zealand

Zakład Diagnostyki Laboratoryjnej, Centrum Onkologii ( Site 2000)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship 85-796

Poland

N.N. Blokhin NMRCO ( Site 2101)

Moscow, Moscow 115478

Russia

Russian Scientific Center of Radiology and Surgical Technologies ( Site 2100)

Saint Petersburg, Sankt-Peterburg 197758

Russia

Samsung Medical Center ( Site 2902)

Gangnam, Seoul 06351

South Korea

Severance Hospital, Yonsei University Health System ( Site 2901)

Seodaemun-gu, Seoul 03722

South Korea

Asan Medical Center ( Site 2900)

Seoul, 05505

South Korea

Hospital Universitari Vall d'Hebron ( Site 2300)

Barcelona, 08035

Spain

Hospital Universitario 12 de Octubre ( Site 2301)

Madrid, 28041

Spain

Taipei Veterans General Hospital ( Site 2800)

Taipei, 11217

Taiwan

ME І.І. Mechnykov Dnipro Regional Clinical Hospital ( Site 2601)

Dnipropetrovsk, Dnipropetrovsk Oblast 49005

Ukraine

CNCE Precarpathian Clinical Oncologic Center ( Site 2600)

Ivano-Frankivsk, Ivano-Frankivsk Oblast 76018

Ukraine

The Beatson West of Scotland Cancer Centre ( Site 2505)

Glasgow, Glasgow City G12 0YN

United Kingdom

St Bartholomew's Hospital ( Site 2500)

London, London, City of EC1A 7BE

United Kingdom

ROYAL MARSDEN HOSPITAL (CHELSEA) ( Site 2502)

London, London, City of SW3 6JJ

United Kingdom

Imperial College Healthcare NHS Trust, Charing Cross Hospital ( Site 2504)

London, London, City of W6 8RF

United Kingdom

The Christie NHS Foundation Trust ( Site 2501)

Manchester, M20 4BX

United Kingdom