Back to Trials
NCT07415031PHASE2Recruiting

A Solid Tumor Study for Long Term Treatment of Cancer Patients Who Participated in Adagrasib Studies

Mirati Therapeutics Inc.

Start Date

5/6/2026

Completion Date

2/16/2028

Summary

This is an open-label, solid tumor, continuation, rollover trial which enrolls participants from ongoing BMS parent studies that evaluated adagrasib (MRTX849, BMS-986503) either as monotherapy or in combination with other cancer therapies in patients with non-small cell lung cancer (NSCLC), colorectal cancer (CRC) and other advanced solid tumors.

Eligibility Criteria

Age Range: 18 years to No maximum

Inclusion Criteria: * Participant is eligible to receive continued study treatment as per the parent study, and/or investigator assessed clinical benefit. * Individuals with assigned female sex at birth (AFSB) must have documented proof that they are not of childbearing potential. IOCBP participants who are sexually active must agree to follow the instructions for method(s) of contraception and included in the ICF. Exclusion Criteria: * Participant is not eligible for study treatment per the parent study eligibility criteria. * Participants who have completed treatment with the study drugs, progressed on prior study treatment, or discontinued study treatment due to toxicity in the parent study are not eligible to receive study drug in this study. * Participants not receiving clinical benefit from parent study drug as assessed by the investigator. Other protocol defined inclusion/exclusion criteria applies.

Interventions

DRUG

Adagrasib

DRUG

Pembrolizumab

DRUG

Cetuximab

DRUG

Pemetrexed

DRUG

Docetaxel

DRUG

Irinotecan

DRUG

Leucovorin

DRUG

Oxaliplatin

DRUG

Fluorouracil

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Solid Tumors

Locations

Local Institution - 0005

Phoenix, Arizona 85054

United States

Southern California Permanente Medical Group

Bellflower, California 90706

United States

Local Institution - 0082

Long Beach, California 90806

United States

Local Institution - 0003

Newark, Delaware 19713

United States

Florida Cancer Specialists - North

St. Petersburg, Florida 33701

United States

Local Institution - 0112

Wichita, Kansas 67208

United States

Local Institution - 0092

Boston, Massachusetts 00215

United States

Local Institution - 0080

Boston, Massachusetts 02215

United States

Mayo Clinic in Rochester, Minnesota

Rochester, Minnesota 55905

United States

Local Institution - 0073

Saint Paul, Minnesota 55101

United States

Local Institution - 0036

Omaha, Nebraska 68114

United States

Oncology Associates Of Oregon, Pc

Eugene, Oregon 97401

United States

The West Clinic, PLLC dba West Cancer Center

Germantown, Tennessee 38138

United States

Texas Oncology-Bedford

Bedford, Texas 76022

United States

Texas Oncology - Baylor Charles A. Sammons Cancer Center

Dallas, Texas 75246

United States

Texas Oncology - DFW

Grapevine, Texas 76051

United States

Local Institution - 0013

Bellingham, Washington 98225

United States

Local Institution - 0093

St Leonards, New South Wales 2065

Australia

Local Institution - 0033

Ghent, 9000

Belgium

Local Institution - 0072

Vancouver, British Columbia V5Z 4E6

Canada

Local Institution - 0037

Beijing, Beijing Municipality 100142

China

Local Institution - 0045

Xiamen, Fujian 361003

China

Local Institution - 0042

Zhengzhou, Henan 450008

China

Local Institution - 0038

Changsha, Hunan 410031

China

Local Institution - 0046

Nanjing, Jiangsu 210012

China

Local Institution - 0048

Nanchang, Jiangxi 330006

China

Local Institution - 0049

Shenyang, Liaoning 110001

China

Local Institution - 0039

Jinan, Shandong 250117

China

Local Institution - 0047

Linyi, Shandong 276000

China

Local Institution - 0043

Shanghai, Shanghai Municipality 200032

China

Local Institution - 0040

Chengdu, Sichuan 610041

China

Local Institution - 0044

Hangzhou, Zhejiang 310022

China

Local Institution - 0041

Xi'an, 710061

China

Local Institution - 0076

Nice, Alpes-Maritimes 06000

France

Local Institution - 0086

Nice, Alpes-Maritimes 06189

France

Local Institution - 0074

Strasbourg, Alsace 67091

France

Local Institution - 0103

Pessac, Aquitaine 33600

France

Local Institution - 0091

Besançon, Doubs 25000

France

Local Institution - 0065

La Tronche, Isère 38700

France

Local Institution - 0063

Saint-Herblain, Loire-Atlantique 44800

France

Local Institution - 0050

Saint-Herblain, Loire-Atlantique 44805

France

Local Institution - 0032

Angers, Maine-et-Loire 49055

France

Local Institution - 0090

Bron, Rhône 69677

France

Local Institution - 0075

Gleizé, Rhône 69400

France

Local Institution - 0051

Poitiers, Vienne 86021

France

Local Institution - 0085

Créteil, 94010

France

Local Institution - 0059

Marseille, 13915

France

Local Institution - 0058

Quimper, 29000

France

Local Institution - 0078

Saint-Mandé, 94163

France

Local Institution - 0077

Tours, 37032

France

Local Institution - 0061

Paris, Île-de-France Region 75014

France

Local Institution - 0012

München, 81737

Germany

Local Institution - 0081

Athens, Attikí 115 28

Greece

Local Institution - 0022

Attiki, 18547

Greece

Local Institution - 0087

Thessaloniki, 54639

Greece

Local Institution - 0089

Budapest, 1121

Hungary

Local Institution - 0067

Budapest, 1122

Hungary

Local Institution - 0055

Jerusalem, Jerusalem 9103102

Israel

Local Institution - 0119

Haifa, 31048

Israel

Local Institution - 0106

Tel Aviv, 6423906

Israel

Local Institution - 0019

Rome, Roma 00144

Italy

Local Institution - 0053

Bologna, 40138

Italy

Local Institution - 0054

Florence, 50139

Italy

Local Institution - 0052

Meldola, 47014

Italy

Local Institution - 0021

Milan, 20141

Italy

Local Institution - 0107

Milan, 20141

Italy

Local Institution - 0020

Orbassano, 10043

Italy

Local Institution - 0079

Pesaro, 61122

Italy

Local Institution - 0031

Roma, 00168

Italy

Local Institution - 0026

Terni (Perugia), 6156

Italy

Local Institution - 0110

Tōon, Ehime 791-0295

Japan

Local Institution - 0056

Breda, North Brabant 4818 CK

Netherlands

Local Institution - 0034

Amsterdam, 1006 BE

Netherlands

Local Institution - 0035

Harderwijk, 3844 DG

Netherlands

Local Institution - 0071

Utrecht, 3543 AZ

Netherlands

Local Institution - 0102

Gdansk, 80-214

Poland

Local Institution - 0101

Lublin, 20-064

Poland

Local Institution - 0014

Lisbon, Lisbon District 1099-023

Portugal

Local Institution - 0060

Craiova, Dolj 200746

Romania

Local Institution - 0088

Singapore, Central Singapore 168583

Singapore

Local Institution - 0069

Gyeonggi-do, 410-769

South Korea

Local Institution - 0070

Seoul, 06351

South Korea

Local Institution - 0068

Seoul, 120-752

South Korea

Local Institution - 0007

A Coruña, A Coruña [La Coruña] 15006

Spain

Local Institution - 0011

Palma, Balears [Baleares] 07120

Spain

Local Institution - 0010

Barcelona, Barcelona [Barcelona] 08028

Spain

Local Institution - 0006

Badalona, Barcelona 08916

Spain

Local Institution - 0030

Santander, Cantabria 39008

Spain

Local Institution - 0024

Madrid, Madrid, Comunidad de 28034

Spain

Local Institution - 0009

Pamplona, Navarre 31008

Spain

Local Institution - 0084

Valencia, Valenciana, Comunitat 46010

Spain

Local Institution - 0029

Barcelona, 08035

Spain

Local Institution - 0027

Córdoba, 14004

Spain

Local Institution - 0083

Madrid, 28007

Spain

Local Institution - 0015

Madrid, 28040

Spain

Local Institution - 0062

Madrid, 28041

Spain

Local Institution - 0018

Málaga, 29011

Spain

Local Institution - 0008

Seville, 41009

Spain

Local Institution - 0115

London, London, City of SE1 9RT

United Kingdom

Local Institution - 0113

Birmingham, B9 5SS

United Kingdom

Local Institution - 0114

Leicester, LE1 5WW

United Kingdom