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NCT07415954PHASE2Recruiting

A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes

Novo Nordisk A/S

Start Date

4/17/2026

Completion Date

10/1/2027

Summary

This study is being done to look at the effect and safety of different doses of NNC0662-0419 in people living with type 2 diabetes when compared to placebo or semaglutide. The purpose of this clinical study is to find out if NNC0662-0419 is effective and safe for treating people living with type 2 diabetes. Participants will get either NNC0662-0419, semaglutide or placebo. Which treatment participants get is decided by chance. NNC0662-0419 is a new medicine which cannot be prescribed by doctors but has previously been tested in humans. Semaglutide is an approved medication to treat type 2 diabetes.

Eligibility Criteria

Age Range: 18 years to 75 years

Inclusion criteria * Male or female (sex at birth). * Age 18-75 years (both inclusive) at the time of signing the informed consent. * Glycated haemoglobin (HbA1c) of 7.0-10.0 percent (%) (53-86 millimoles per mole \[mmol/mol\]) (both inclusive) as assessed by central laboratory at screening. * Willingness to obtain a high weight loss (greater than \[\>\] 25% of weight at baseline). Exclusion criteria * Treatment with any medication for the indication of diabetes or obesity other than stated in the inclusion criteria within 90 days before screening. However, short term insulin treatment for a maximum of 14 consecutive days and prior insulin treatment for gestational diabetes are allowed. * Uncontrolled and potentially unstable diabetic retinopathy or maculopathy. Pharmacological pupil-dilation is a requirement unless using a digital fundus photography camera specified for non-dilated examination. * Known hypoglycaemic unawareness as indicated by the investigator according to Clarke's Questionnaire.

Interventions

DRUG

NNC0662-0419

DRUG

Semaglutide

DRUG

Placebo

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Conditions

Diabetes Mellitus, Type 2

Locations

First Valley Medical Group

Lancaster, California 93534

United States

Torrance Clinical Research Institute, Inc.

Lomita, California 90717

United States

Ark Clinical Research

Long Beach, California 90815

United States

Pacific Clinical Studies

Los Alamitos, California 90720

United States

Wetlin Research Associates, Inc.

San Diego, California 92120

United States

Diablo Clinical Research, Inc.

Walnut Creek, California 94598

United States

Encore Medical Research LLC

Hollywood, Florida 33024

United States

Bioclinical Research Alliance

Miami, Florida 33155

United States

South Broward Research LLC

Miramar, Florida 33027

United States

West Orange Endocrinology

Ocoee, Florida 34761

United States

Encore Medical Research of Weston

Weston, Florida 33331

United States

Elite Clinical Trials

Blackfoot, Idaho 83221

United States

Cedar-Crosse Research Center

Chicago, Illinois 60607

United States

Brigham & Women's Hospital

Boston, Massachusetts 02115-5804

United States

Headlands Research

Springfield, Missouri 65807

United States

PharmQuest

Greensboro, North Carolina 27408

United States

Piedmont Healthcare Statesville

Statesville, North Carolina 28625

United States

Providence Center for Clinical Research

Dayton, Ohio 45439

United States

CNS Healthcare

Memphis, Tennessee 38119

United States

University of Texas Southwestern Medical Center

Dallas, Texas 75390-9302

United States

JCCT- Juno NW Houston

Houston, Texas 77040

United States

Consano Clinical Research, LLC

Shavano Park, Texas 78231

United States

Frontier Clinical Research - Kingwood

Kingwood, West Virginia 26537

United States

Opca bolnica Karlovac

Karlovac, 47000

Croatia

Poliklinika SLAVONIJA OSIJEK

Osijek, 31000

Croatia

Opca bolnica Varazdin_Endocrinology

Varaždin, 42 000

Croatia

Poliklinika Solmed

Zagreb, 10000

Croatia

Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ

Szeged, Csongrád-Csanád 6725

Hungary

Debreceni Egyetem

Debrecen, Hajdú-Bihar 4032

Hungary

Debreceni Egyetem

Debrecen, 4031

Hungary

Akaicho Clinic_Internal medicine

Chiba-shi, Chiba, 260-0804

Japan

Naka Kinen Clinic_Internal medicine

Ibaraki, 311-0113

Japan

Soka Sugiura Internal Medicine Clinic

Soka-shi, Saitama, 340-0015

Japan

Tokyo-Eki Center-building Clinic_Internal Medicine

Tokyo, 103-0027

Japan

ToCROM Clinic_Internal Medicine

Tokyo, 160-0008

Japan

"Zdrowie Osteo-Medic" s.c. Lidia i Artur Racewicz, Agnieszka i Jerzy Supronik

Bialystok, Podlaskie Voivodeship 15-351

Poland

Terpa Sp. z o.o. Sp. k.

Lublin, 20-333

Poland

Formed 2 Sp. z o.o.

Oświęcim, 32-600

Poland

PANSTWOWY INSTYTUT MEDYCZNY MSWiA

Warsaw, 02-507

Poland

Samodzielny Publiczny Szpital Kliniczny Nr 1 im. Prof. Szyszko

Zabrze, 41-800

Poland

Casa De Saúde De Santa Filomena S.A._Unidade de Ensaios Clínicos

Coimbra, 3000-150

Portugal

Cardiolima Centro Diagnostico Cardio-Pulmonar De Ponte De Lima Lda

Ponte de Lima, 4990-029

Portugal

Hospital Trofa Saude Senhor do Bonfim S.A_Unidade de Ensaios Clínicos

Vila do Conde, 4480-565

Portugal

Hospital da Luz Arrábida, S.A_Serviço de Endocrinologia

Vila Nova de Gaia, 4400-346

Portugal

DIADA, s.r.o.

Bardejov, 08501

Slovakia

Metabol KLINIK s.r.o.

Bratislava, 811 08

Slovakia

Diacrin s. r. o.

Bratislava, 83101

Slovakia

SIN AZUCAR s.r.o.

Malacky, 901 01

Slovakia

Korea University Ansan Hospital_Endocrinology

Ansan-si, Gyeonggi-do 15355

South Korea

Pusan National University Yangsan Hospital

Yangsan, Gyeongsangnam-do 50612

South Korea

Nowon Eulji Medical Center, Eulji University_Endocrinology

Seoul, 01830

South Korea

Kangbuk Samsung Hospital_Endocrinology

Seoul, 03181

South Korea

ABS La Roca CAP Vicenç_Endocrino

La Roca Del Vallés, Barcelona 08430

Spain

Centro de Salud A Estrada

A Estrada, 36680

Spain

Equip D´Atencio Primaria Barcelona Sardenya

Barcelona, 08025

Spain

Hospital Vithas Sevilla

Castilleja de la Cuesta, 41950

Spain

Clínica Bofill

Girona, 17002

Spain

Centro de Saúde Concepción Arenal

Santiago de Compostela, 15701

Spain

Ramathibodi Hospital

Bangkok, 10400

Thailand

Siriraj Hospital

Bangkok, 10700

Thailand

Maharaj Nakorn Chiang Mai

Chiang Mai, 50200

Thailand

Srinagarind Hospital

Khon Kaen, 40002

Thailand

Maharat Nakhon Ratchasima Hospital

Nakhon Ratchasima, 30000

Thailand