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NCT07417111NARecruiting

Continued Pressure for Alveolar Protection (CPAP Trial)

NICHD Neonatal Research Network

Start Date

11/5/2026

Completion Date

1/30/2029

Summary

The objective of the CPAP Trial is to test whether extending CPAP until 34 weeks' PMA or for at least 2 additional weeks compared to weaning to a nasal canula will decrease the likelihood of bronchopulmonary dysplasia or death at 36 weeks' PMA.

Eligibility Criteria

Age Range: No minimum to No maximum

Inclusion Criteria: * Gestational age \<29 weeks at birth * PMA \<32 weeks at study entry * On treatment with CPAP without a rate in FiO2 \<0.25 and PEEP of 4-5 cmH2O * Meet stability criteria: * If previously intubated must be extubated ≥ 72 hours * \<3 self-resolving apneas (≤ 20 s) and/or bradycardia (\<100 bpm) in any hour over previous 6 hours * No episodes of apnea or bradycardia requiring intervention (oxygen/stimulation/bag and mask) for 24 hours * Parents/legal guardians consent for enrollment Exclusion Criteria: * Major malformation * Neuromuscular condition that affects respiration * Terminal illness * Decision to withhold or limit support * Too sick to participate in opinion of Attending physician * Clinical shock, sepsis * Planned surgery during study period

Interventions

DEVICE

CPAP

DEVICE

Nasal Cannula

Interested in This Trial?

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Conditions

Bronchopulmonary Dysplasia (BPD)

Locations

University of Alabama at Birmingham

Birmingham, Alabama 35233

United States

Stanford University

Palo Alto, California 94304

United States

Sharp Mary Birch Hospital for Women & Newborns

San Diego, California 92123

United States

Emory University

Atlanta, Georgia 30303

United States

Northwestern Lurie Children's Hospital of Chicago

Chicago, Illinois 60611

United States

University of Iowa

Iowa City, Iowa 52242

United States

University of Mississippi Medical Center - Children's of Mississippi

Jackson, Mississippi 39216

United States

University of New Mexico

Albuquerque, New Mexico 87131

United States

Duke University

Durham, North Carolina 27710

United States

Cincinnati Children's Medical Center

Cincinnati, Ohio 45267

United States

Case Western Reserve University, Rainbow Babies and Children's Hospital

Cleveland, Ohio 44106

United States

University of Pennsylvania

Philadelphia, Pennsylvania 19104

United States

University of Texas Southwestern Medical Center at Dallas

Dallas, Texas 75235

United States

University of Texas Health Science Center at Houston

Houston, Texas 77030

United States

University of Utah

Salt Lake City, Utah 84108

United States