NCT07425899PHASE1RecruitingAccepts Healthy Volunteers
A Phase 1 Study of the Safety and How the Body Processes ABBV-722 and Upadacitinib After Multiple Oral Doses in Healthy Adult Participants
AbbVie
Start Date
2/26/2026
Completion Date
8/1/2026
Summary
This is a Phase 1 study to investigate safety and pharmacokinetics of ABBV-722 and Upadacitinib following multiple oral doses in healthy adult participants.
Eligibility Criteria
Age Range: 18 years to 65 years
Inclusion Criteria:
* Laboratory values meet the criteria specified in the protocol.
* A condition of general good health, based upon the results of a medical history, physical examination, vital signs, laboratory profile, and a 12-lead electrocardiogram (ECG).
Exclusion Criteria:
* History of any clinically significant illness/infection/major febrile illness, hospitalization, or any surgical procedure within 30 days prior to the first dose of study drug.
* Chronic recurring infection and/or active viral infection.
* Consumption of alcohol, grapefruit products, Seville oranges, starfruit products or quinine/tonic water within the 72-hour period prior to study drug administration.
* Use of tobacco or nicotine-containing products within 90 days prior to the first dose of study drug.
* Evidence of dysplasia or history of malignancy (including lymphoma and leukemia) other than successfully treated non-metastatic cutaneous squamous cell, basal cell carcinoma or localized carcinoma in situ of the cervix.
* History or evidence of active tuberculosis (TB) disease or latent TB infection
* Prior exposure to ABBV-722 within 90 days prior to the first dose of study drug.
Interventions
DRUG
ABBV-722
DRUG
Upadacitinib
Conditions
Healthy Volunteer
Locations
Acpru /Id# 279285
Grayslake, Illinois 60030
United States