NCT07426016NARecruiting

Video vs. Direct Laryngoscopy for Less Invasive Surfactant Administration

University of Texas Southwestern Medical Center

Start Date

6/11/2026

Completion Date

11/1/2028

Summary

Many preterm babies born between 22-28+6 weeks' estimated gestational age (EGA) need surfactant, a medicine that helps the lungs. The goal of the study is to compare the use of video-based visualization to direct visualization during a procedure called less invasive surfactant administration (LISA). The main questions the study aims to answer are: 1) does one method of visualization have a increased rate of giving the medicine successfully on the first attempt? 2) what benefits are there of each method?

Eligibility Criteria

Age Range: No minimum to No maximum

Inclusion Criteria: * Infants born ≤28 weeks GA successfully resuscitated in the delivery room (DR) and maintained on CPAP • Need for surfactant in the first 36 hours of life based on clinical assessment and/or meeting threshold per unit protocol Exclusion Criteria: * Infants born ≥29 weeks GA or * Infants with known congenital anomalies or * Infants who are determined by the primary care team to receive comfort care only or * Infants who are intubated at any time prior to surfactant administration

Interventions

PROCEDURE

Video Laryngoscopy

PROCEDURE

Direct Laryngoscopy

Interested in This Trial?

Contact the trial locations directly using the information below to learn more about enrollment.

Expressing interest lets you review the study and consent before we connect you with the research site.

Conditions

Respiratory Distress Syndrome (Neonatal)Surfactant Deficiency Syndrome Neonatal

Locations

Parkland Hospital

Dallas, Texas 75235

United States