NCT07435194PHASE1RecruitingAccepts Healthy Volunteers

A Clinical Trial in Healthy Participants to Learn How Itraconazole Affects MK-2828 Levels and How MK-2828 Affects Midazolam Levels (MK-2828-007)

Merck Sharp & Dohme LLC

Start Date

3/6/2026

Completion Date

8/12/2026

Summary

The main goals of this study are: * To learn what happens to one dose of MK-2828 in a healthy person's body over time when it is taken with itraconzole * To learn what happens to one dose of midazolam in a healthy person's body over time when it is taken with MK-2828 Researchers want to learn if the levels of MK-2828 in the body are about the same when MK-2828 is taken with itraconazole as when it is taken alone. They also want to know if taking MK-2828 more than once affects how much midazolam is in the body after a single dose.

Eligibility Criteria

Age Range: 24 years to 60 years

Inclusion Criteria: The main inclusion criteria include but are not limited to the following: \- Participant is in good health Exclusion Criteria: The main exclusion criteria include but are not limited to the following: * History of cancer (malignancy) * History of clinically significant endocrine, gastrointestinal, cardiovascular, hematological, hepatic, immunological, renal, respiratory, genitourinary, or major neurological (including stroke and chronic seizures) abnormalities or diseases

Interventions

DRUG

MK-2828

DRUG

Itraconazole

DRUG

Midazolam

Interested in This Trial?

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Conditions

Healthy

Locations

Fortea CRU Madison ( Site 0001)

Madison, Wisconsin 53704

United States