A Study to Assess the Effectiveness and Safety of IPN10200 Over Time in Adults With Moderate to Severe Wrinkle-like Lines Between the Eyebrows
Start Date
2/18/2026
Completion Date
10/1/2028
Summary
The purpose of this study is to assess the effectiveness and safety of a single dose of Corabotase (also known as IPN10200) compared to placebo (double-blind phase) and how well and safely repeat doses of Corabotase work over time (open-label phase) in adult participants with moderate to severe glabellar lines. Glabellar lines are wrinkle-like lines that appear between the eyebrows and can become more noticeable with age or repeated facial expressions. They may affect a person's appearance and confidence. All participants in the double-blind phase will receive Corabotase or placebo during the first treatment cycle. De novo participants in the open-label phase will receive IPN10200 during the first treatment cycle. Some participants may receive additional treatment cycles with Corabotase depending on their eligibility. There will be 3 periods in this study: * A screening period (up to 20 days) to assess whether the participant can take part, requiring at least 1 visit to the study centre. * A treatment period where participants may receive up to 4 treatment cycles. In the double-blind phase, participants receive a single treatment of Corabotase or placebo. In the open-label phase (rollover participants from double-blind), eligible participants may receive additional cycles of Corabotase . In the open-label phase (de novo participants), participants will receive Corabotase in the first cycle and eligible participants may receive additional cycles of Corabotase. Requires multiple visits during the first month followed by 1 visit every month. * A follow-up period (24 weeks) after the last injection where participants' health will be monitored. Participants will undergo health measurements and observation, including blood sampling, physical examinations, clinical evaluations and electrocardiograms (ECG: recording of the electrical activity of heart). They will also be asked to fill in questionnaires and keep a diary. Each participant will be in this study for up to 107 weeks. Participants may withdraw consent to participate at any time.
Eligibility Criteria
Age Range: 18 years to 80 years
Interventions
Corabotase
Placebo
Conditions
Locations
Rivkin Westside Aesthetics
Los Angeles, California 90025
United States
Clinical Testing of Beverly Hills
Los Angeles, California 91436
United States
Eye Research Foundation
Newport Beach, California 92663
United States
Steve Yoelin MD Medical Associates Inc
Newport Beach, California 92663
United States
Skin and Beauty Center
Pasadena, California 91105
United States
Dermatology Cosmetic Laser Medical Associates of La Jolla Inc.
San Diego, California 92121
United States
Southern California Dermatology, Inc.
Santa Ana, California 92701
United States
DMR Research, PLLC
Westport, Connecticut 06880
United States
Center for Dermatology and Dermatologic Surgery
Washington D.C., District of Columbia 20037
United States
Skin and Cancer Associates (SCA) and the Center for Cosmetic Enhancement (CCE) - Aventura
Aventura, Florida 33180
United States
Weinkle Dermatology
Bradenton, Florida 34209
United States
Skin Research Institute
Coral Gables, Florida 33146
United States
Miami Dermatology & Laser Research
Miami, Florida 33133
United States
Kavali Plastic Surgery and Skin Renewal Center
Atlanta, Georgia 30328
United States
DeNova Research
Chicago, Illinois 60610
United States
Chicago Cosmetic and Dermatologic Research
Chicago, Illinois 60654-5826
United States
Advanced Dermatology, A Forefront Dermatology Practice
Lincolnshire, Illinois 60069
United States
LASSI - Laser and Skin Surgery Center of Indiana
Indianapolis, Indiana 46260
United States
Coleman Center For Cosmetic Dermatologic Surgery
Metairie, Louisiana 70006
United States
DelRicht Research
New Orleans, Louisiana 70115
United States
Etre, Cosmetic Dermatology and Laser Center
New Orleans, Louisiana 70130
United States
Maryland Laser, Skin, & Vein Institute, LLC (MDLSV)
Hunt Valley, Maryland 21030
United States
Lawrence J. Green, MD. LLC
Rockville, Maryland 20850
United States
SkinCare Physicians
Chestnut Hill, Massachusetts 02467
United States
Michigan Center for Research Company
Clarkston, Michigan 48346
United States
Skin Specialists PC dba Schlessinger MD
Omaha, Nebraska 68144
United States
StracSkin
Portsmouth, New Hampshire 03801
United States
Rejuva Center at Williams
Latham, New York 12110
United States
The Center for Dermatology, Cosmetic & Laser Surgery
Mount Kisco, New York 10549
United States
Luxurgery
New York, New York 10021
United States
Dr. Z. Paul Lorenc MD, Office Of
New York, New York 10028
United States
Skin Search Of Rochester, Inc.
Rochester, New York 14623
United States
Rochester Dermatologic Surgery, P.C.
Victor, New York 14561
United States
Aesthetic Solutions P.A.
Chapel Hill, North Carolina 27517
United States
Dermatology, Laser & Vein Specialists of the Carolinas (DLVSC) - Charlotte Office
Charlotte, North Carolina 28207
United States
Nash Research Group, LLC
Powell, Ohio 43065
United States
Oregon Dermatology and Research Center
Portland, Oregon 97210
United States
Paddington Testing Company
Philadelphia, Pennsylvania 19103
United States
Brian S. Biesman MD, PLLC
Nashville, Tennessee 37203
United States
Tennessee Clinical Research Center
Nashville, Tennessee 37215
United States
Center for Clinical Studies
Webster, Texas 77598
United States
Sas Aimed
Lyon, 69006
France
Institut Cyrnos
Nice, 6000
France
Thinkin SAS
Paris, 75016
France
Rosenpark Research GmbH
Darmstadt, 64283
Germany
Privatpraxis Dr. Hilton & Partner
Düsseldorf, 40212
Germany
Universitaet Hamburg - Institut fuer Biochemie und Molekularbiologie
Hamburg, 20146
Germany
Derma Science GmbH
Hamburg, 22609
Germany
Noahklinik- Klinik fuer Plastische Chirurgie
Kassel, 34117
Germany
Dermatologische Gemeinschaftspraxis
Mahlow, 15831
Germany
Skin Concept - Private Dermatology Practice
München, 80333
Germany
Haut- und Lasercentrum Potsdam
Potsdam, 14467
Germany
Akihabara Skin Clinic
Chiyoda-ku, 101-0021
Japan
Medical Corporation Chiseikai - Tokyo Center Clinic
Chūōku, 103-0027
Japan
Josui Dermatology Clinic
Fukuoka, 810-0022
Japan
Clinica BellaForma
Minatoku, 107-0052
Japan
Forest Palace Dermatology Clinic
Nerima-ku, 177-0041
Japan
Kume Derma Clinic
Sakaishi, 593-8324
Japan
Kotoni Tower Dermatology and Plastic Surgery
Sapporo, 063-0812
Japan
Yoshikawa Skin Clinic
Takatsuki-shi, 569-0824
Japan